The DOI matches its Crossref record; 317 of the 321 references it cites were found in a registry or an index.
Epilepsy in children
Abstract
10.5 million children worldwide are estimated to have active epilepsy. Over the past 15 years, syndrome-oriented clinical and EEG diagnosis, and better aetiological diagnosis, especially supported by neuroimaging, has helped to clarify the diversity of epilepsy in children, and has improved management. Perinatal and postinfective encephalopathy, cortical dysplasia, and hippocampal sclerosis account for the most severe symptomatic epilepsies. Ion channel defects can underlie both benign age-related disorders and severe epileptic encephalopathies with a progressive disturbance in cerebral function. However, the reasons for age-related expression in children are not understood. Neither are the mechanisms whereby an epileptic encephalopathy originates. Several new drugs have been recently introduced but have provided limited therapeutic benefits. However, treatment and quality of life have improved because the syndrome-specific efficacy profile of drugs is better known, and there is heightened awareness that compounds with severe cognitive side-effects and heavy polytherapies should be avoided. Epilepsy surgery is an important option for a few well-selected individuals, but should be considered with great caution when there is no apparent underlying brain lesion.
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“This is a delicate matter, as simply adopting a protocol reduces mortality and morbidity, although there is little evidence to show that one of the numerous recommended protocols is better than another 211 .”
From Developmental and epileptic encephalopathies (2024) · cites this paper as [211]
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2 retracted
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Metadata
- Authors
- Guerrini, R.
- Affiliations
- University of Pisa (IT)
- Corresponding author
- Guerrini, Renzo
- ORCID
- Guerrini, Renzo
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 367
- Issue
- 9509
- Pages
- 499-524
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2047243927
- Cited by
- 848
- References
- 321
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 30 · 2023: 27 · 2022: 33 · 2021: 33 · 2020: 21 · 2019: 22 · 2018: 19 · 2017: 20 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 31 · 2012: 33
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Keywords
- pediatric epilepsy, epileptic encephalopathy, perinatal encephalopathy, cortical dysplasia, hippocampal sclerosis, ion channel disorders, benign rolandic epilepsy, antiepileptic drugs, epilepsy surgery, etiology, neuroimaging, EEG diagnosis, cognitive side effects
- MeSH terms
- Adolescent, Anticonvulsants, Child, Child, Preschool, Epilepsy, Humans, Infant, Infant, Newborn, Prognosis
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