Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,272

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Biological, clinical, and ethical advances of placebo effects

Open access
Finniss, Damien G, Kaptchuk, Ted J, Miller, Franklin, Benedetti, Fabrizio·2010·The Lancet
DOI 10.1016/s0140-6736(09)61706-2
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(09)61706-2

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 23 references

Research works printed but not linked: 82

  1. Aronson, 1999, Please, please me, BMJ, 318, 716, 10.1136/bmj.318.7185.716 · doi:10.1136/bmj.318.7185.716
  2. Kaptchuk, 2009, Placebo controls, exorcisms, and the devil, Lancet, 374, 1234, 10.1016/S0140-6736(09)61775-X · doi:10.1016/s0140-6736(09)61775-x
  3. Kaptchuk, 1998, Intentional ignorance: a history of blind assessment and placebo controls in medicine, Bull Hist Med, 72, 389, 10.1353/bhm.1998.0159 · DOI · Paper page
  4. Kerr, 2008, William Cullen and a missing mind-body link in the early history of placebos, J R Soc Med, 101, 89, 10.1258/jrsm.2007.071005 · DOI
  5. Beecher, 1955, The powerful placebo, JAMA, 159, 1602, 10.1001/jama.1955.02960340022006 · DOI · Paper page
  6. Moerman, 2002, Deconstructing the placebo effect and finding the meaning response, Ann Intern Med, 136, 471, 10.7326/0003-4819-136-6-200203190-00011 · DOI · Paper page
  7. Moerman, 2003, “Placebo” versus “meaning”: the case for a change in our use of language, Prevent Treat, 6, 1, 10.1037/1522-3736.6.1.67c · DOI
  8. Stewart-Williams, 2004, The placebo puzzle: putting together the pieces, Health Psychol, 23, 198, 10.1037/0278-6133.23.2.198 · DOI
  9. Ernst, 1995, Concept of true and perceived placebo effects, BMJ, 311, 551, 10.1136/bmj.311.7004.551 · DOI · Paper page
  10. Di Blasi, 2001, Influence of context effects on health outcomes: a systematic review, Lancet, 357, 757, 10.1016/S0140-6736(00)04169-6 · DOI · Paper page
  11. Di Blasi, 2003, Context effects. Powerful therapies or methodological bias?, Eval Health Prof, 26, 166, 10.1177/0163278703026002003 · DOI
  12. Miller, 2008, The power of context: reconceptualizing the placebo effect, J R Soc Med, 101, 222, 10.1258/jrsm.2008.070466 · DOI · Paper page
  13. Kaptchuk, 2009, “Maybe I made up the whole thing”: placebos and patients' experiences in a randomized controlled trial, Cult Med Psychiatry, 33, 382, 10.1007/s11013-009-9141-7 · DOI · Paper page
  14. Amanzio, 1999, Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems, J Neurosci, 19, 484, 10.1523/JNEUROSCI.19-01-00484.1999 · DOI · Paper page
  15. Benedetti, 1996, The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia, Pain, 64, 535, 10.1016/0304-3959(95)00179-4 · DOI · Paper page
  16. Benedetti, 1997, Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide, Pain, 71, 135, 10.1016/S0304-3959(97)03346-0 · DOI · Paper page
  17. Scott, 2008, Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses, Arch Gen Psychiatry, 65, 220, 10.1001/archgenpsychiatry.2007.34 · DOI · Paper page
  18. de la Fuente-Fernandez, 2001, Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease, Science, 293, 1164, 10.1126/science.1060937 · DOI · Paper page
  19. Benedetti, 2004, Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus, Nat Neurosci, 7, 587, 10.1038/nn1250 · DOI · Paper page
  20. Benedetti, 2009, Electrophysiological properties of thalamic, subthalamic and nigral neurons during the anti-parkinsonian placebo response, J Physiol, 587, 3869, 10.1113/jphysiol.2009.169425 · DOI
  21. Mayberg, 2002, The functional neuroanatomy of the placebo effect, Am J Psychiatry, 159, 728, 10.1176/appi.ajp.159.5.728 · DOI · Paper page
  22. Leuchter, 2002, Changes in brain function of depressed subjects during treatment with placebo, Am J Psychiatry, 159, 122, 10.1176/appi.ajp.159.1.122 · DOI · Paper page
  23. Lanotte, 2005, Expectation enhances autonomic responses to stimulation of the human subthalamic limbic region, Brain Behav Immun, 19, 500, 10.1016/j.bbi.2005.06.004 · DOI
  24. Pollo, 2003, Placebo analgesia and the heart, Pain, 102, 125, 10.1016/s0304-3959(02)00345-7 · DOI
  25. Benedetti, 1999, Somatotopic activation of opioid systems by target-directed expectations of analgesia, J Neurosci, 19, 3639, 10.1523/JNEUROSCI.19-09-03639.1999 · DOI · Paper page
  26. Ader, 1975, Behaviourally conditioned immunosuppression, Psychosom Med, 37, 333, 10.1097/00006842-197507000-00007 · DOI · Paper page
  27. Goebel, 2002, Behavioral conditioning of immunosuppression is possible in humans, FASEB J, 16, 1869, 10.1096/fj.02-0389com · DOI · Paper page
  28. Pollo, 2008, The top-down influence of ergogenic placebos on muscle work and fatigue, Eur J Neurosci, 28, 379, 10.1111/j.1460-9568.2008.06344.x · DOI
  29. Benedetti, 2008, Mechanisms of placebo and placebo-related effects across diseases and treatments, Annu Rev Pharmacol Toxicol, 48, 33, 10.1146/annurev.pharmtox.48.113006.094711 · DOI · Paper page
  30. Kirsch, 1985, Response expectancy as a determinant of experience and behavior, Am Psychol, 40, 1189, 10.1037/0003-066X.40.11.1189 · DOI · Paper page
  31. Price, 1999, An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm, Pain, 83, 147, 10.1016/S0304-3959(99)00081-0 · DOI · Paper page
  32. Vase, 2003, The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients. An empirical investigation, Pain, 105, 17, 10.1016/S0304-3959(03)00073-3 · DOI · Paper page
  33. Pollo, 2002, Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients, Neuroreport, 13, 1383, 10.1097/00001756-200208070-00006 · DOI · Paper page
  34. Voudouris, 1989, Conditioned response models of placebo phenomena: further support, Pain, 38, 109, 10.1016/0304-3959(89)90080-8 · DOI · Paper page
  35. Herrnstein, 1962, Placebo effect in the rat, Science, 138, 677, 10.1126/science.138.3541.677 · DOI · Paper page
  36. Pacheco-Lopez, 2006, Expectations and associations that heal: immunomodulatory placebo effects and its neurobiology, Brain Behav Immun, 20, 430, 10.1016/j.bbi.2006.05.003 · DOI · Paper page
  37. Stewart-Williams, 2004, The placebo effect: dissolving the expectancy versus conditioning debate, Psychol Bull, 130, 324, 10.1037/0033-2909.130.2.324 · DOI · Paper page
  38. Montgomery, 1997, Classical conditioning and the placebo effect, Pain, 72, 107, 10.1016/S0304-3959(97)00016-X · DOI · Paper page
  39. Rescorla, 1988, Pavlovian conditioning. It's not what you think it is, Am Psychol, 43, 151, 10.1037/0003-066X.43.3.151 · DOI · Paper page
  40. Finniss, 2005, Mechanisms of the placebo response and their impact on clinical trials and clinical practice, Pain, 114, 3, 10.1016/j.pain.2004.12.012 · DOI
  41. Colloca, 2005, Placebos and painkillers: is mind as real as matter?, Nat Rev Neurosci, 6, 545, 10.1038/nrn1705 · DOI · Paper page
  42. Levine, 1984, Influence of the method of drug administration on analgesic response, Nature, 312, 755, 10.1038/312755a0 · DOI · Paper page
  43. Benedetti, 1995, Potentiation of placebo analgesia by proglumide, Lancet, 346, 1231, 10.1016/S0140-6736(95)92938-X · DOI · Paper page
  44. Benedetti, 1997, The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin, Prog Neurobiol, 52, 109, 10.1016/S0301-0082(97)00006-3 · DOI · Paper page
  45. Montgomery, 1996, Mechanisms of placebo pain reduction. An imperical investigation, Psychol Sci, 7, 174, 10.1111/j.1467-9280.1996.tb00352.x · DOI · Paper page
  46. Lipman, 1990, Peak B endorphin concentration in cerebrospinal fluid: reduced in chronic pain patients and increased during the placebo response, Psychopharmacology, 102, 112, 10.1007/BF02245754 · DOI
  47. Wager, 2004, Placebo-induced changes in fMRI in the anticipation and experience of pain, Science, 303, 1162, 10.1126/science.1093065 · DOI · Paper page
  48. Price, 2007, Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients, Pain, 127, 63, 10.1016/j.pain.2006.08.001 · DOI · Paper page
  49. Benedetti, 1999, Inducing placebo respiratory depressant responses in humans via opioid receptors, Euro J Neurosci, 11, 625, 10.1046/j.1460-9568.1999.00465.x · DOI
  50. de la Fuente-Fernandez, 2002, The placebo effect in Parkinson's disease, Trends Neurosci, 25, 302, 10.1016/S0166-2236(02)02181-1 · DOI · Paper page
  51. Hrobjartsson, 2001, Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment, N Engl J Med, 344, 1594, 10.1056/NEJM200105243442106 · DOI · Paper page
  52. Hrobjartsson, 2004, Is the placebo effect powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment, J Intern Med, 256, 91, 10.1111/j.1365-2796.2004.01355.x · DOI · Paper page
  53. Hrobjartsson, 2004, Placebo interventions for all clinical conditions, Cochrane Database Syst Rev, 3, 10.1002/14651858.CD003974.pub2 · DOI
  54. Hrobjartsson, 2006, Unsubstantiated claims of large effects of placebo on pain: serious errors in meta-analysis of placebo analgesia mechanism studies, J Clin Epidemiol, 59, 336, 10.1016/j.jclinepi.2005.05.011 · DOI
  55. Steitberger, 1998, Introducing a placebo needle into acupuncture research, Lancet, 352, 364, 10.1016/S0140-6736(97)10471-8 · DOI · Paper page
  56. Camilleri, 2000, Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial, Lancet, 355, 1035, 10.1016/S0140-6736(00)02033-X · DOI · Paper page
  57. Kaptchuk, 2000, Do medical devices have enhanced placebo effects?, J Clin Epidemiol, 53, 786, 10.1016/S0895-4356(00)00206-7 · DOI · Paper page
  58. Kaptchuk, 2006, Sham device v inert pill: randomised controlled trial of two placebo treatments, BMJ, 332, 391, 10.1136/bmj.38726.603310.55 · DOI · Paper page
  59. Kaptchuk, 2002, The placebo effect in alternative medicine: can the performance of a healing ritual have clinical significance?, Ann Intern Med, 136, 817, 10.7326/0003-4819-136-11-200206040-00011 · DOI · Paper page
  60. Kaptchuk, 1998, The persuasive appeal of alternative medicine, Ann Intern Med, 129, 1061, 10.7326/0003-4819-129-12-199812150-00011 · DOI · Paper page
  61. Linde, 2005, Acupuncture for patients with migraine: a randomized controlled trial, JAMA, 293, 2118, 10.1001/jama.293.17.2118 · DOI · Paper page
  62. Melchart, 2005, Acupuncture in patients with tension-type headache: randomised controlled trial, BMJ, 331, 376, 10.1136/bmj.38512.405440.8F · DOI · Paper page
  63. Brinkhaus, 2006, Acupuncture in patients with chronic low back pain: a randomized controlled trial, Arch Intern Med, 166, 450
  64. Haake, 2007, German Acupuncture Trials (GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups, Arch Intern Med, 167, 1892, 10.1001/Archinte.167.17.1892 · DOI · Paper page
  65. Witt, 2005, Acupuncture in patients with osteoarthritis of the knee: a randomised trial, Lancet, 366, 136, 10.1016/S0140-6736(05)66871-7 · DOI · Paper page
  66. Cummings, 2009, Modellvorhaben Akupunktur—a summary of the ART, ARC and GERAC trials, Acupunct Med, 27, 26, 10.1136/aim.2008.000281 · DOI
  67. Linde, 2007, The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain, Pain, 128, 264, 10.1016/j.pain.2006.12.006 · DOI · Paper page
  68. Cherkin, 2009, A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain, Arch Intern Med, 169, 858, 10.1001/archinternmed.2009.65 · DOI · Paper page
  69. Sherman KJ, Cherkin DC, Ichikawa L, et al. Treatment expectations and preferences as predictors of outcome in acupuncture for chronic back pain. Spine (in press).
  70. Colloca, 2004, Overt versus covert treatment for pain, anxiety, and Parkinson's disease, Lancet Neurol, 3, 679, 10.1016/S1474-4422(04)00908-1 · DOI · Paper page
  71. Price, 2001, Assessing placebo effects without placebo groups: an untapped possibility?, Pain, 90, 201, 10.1016/S0304-3959(01)00265-2 · DOI
  72. Amanzio, 2001, Response variability to analgesics: a role for non-specific activation of endogenous opioids, Pain, 90, 205, 10.1016/S0304-3959(00)00486-3 · DOI · Paper page
  73. Benedetti, 2003, Open versus hidden medical treatments: the patient's knowledge about a therapy affects the therapy outcome, Prevent Treat, 6
  74. Verne, 2003, Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients, Pain, 105, 223, 10.1016/S0304-3959(03)00210-0 · DOI · Paper page
  75. Gracely, 1985, Clinicians' expectations influence placebo analgesia, Lancet, 325, 43, 10.1016/S0140-6736(85)90984-5 · DOI · Paper page
  76. Benedetti, 2006, Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective, Pain, 121, 133, 10.1016/j.pain.2005.12.016 · DOI · Paper page
  77. Miller, 2005, Deception in research on the placebo effect, PLoS Med, 2, e262, 10.1371/journal.pmed.0020262 · DOI · Paper page
  78. Brody, 1982, The lie that heals: the ethics of giving placebos, Ann Intern Med, 97, 112, 10.7326/0003-4819-97-1-112 · DOI · Paper page
  79. Hrobjartsson, 2003, The use of placebo interventions in medical practice—a national questionnaire survey of Danish clinicians, Eval Health Prof, 26, 153, 10.1177/0163278703026002002 · DOI
  80. Tilburt, 2008, Prescribing “placebo treatments”: results of national survey of US internists and rheumatologists, BMJ, 337, a1938, 10.1136/bmj.a1938 · DOI · Paper page
  81. Park, 1965, Nonblind placebo trial: an exploration of neurotic patients' responses to placebo when its inert content is disclosed, Arch Gen Psychiatry, 12, 336, 10.1001/archpsyc.1965.01720340008002 · DOI
  82. Aulas, 2003, Efficacy of a non blind placebo prescription, Encephale, 29, 68

Cited by

See all 1,272

Metadata

Authors
Finniss, D. G., Kaptchuk, T. J., Miller, F., & Benedetti, F.
Venue
The Lancet
Publisher
Elsevier BV
Published
2010-02
Volume
375
Issue
9715
Pages
686-695
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(09)61706-2
OpenAlex
W2157903425
Cited by
1,272
References
23
FWCI
51.05
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Biological, clinical, and ethical advances of placebo effects. https://app.cochat.ai/papers/10.1016/s0140-6736(09)61706-2
The paper
Finniss, D. G., Kaptchuk, T. J., Miller, F., & Benedetti, F. (2010). Biological, clinical, and ethical advances of placebo effects. The Lancet. https://doi.org/10.1016/s0140-6736(09)61706-2

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.