The DOI matches its Crossref record; 134 of the 136 references it cites were found in a registry or an index.
Selenium and human health
Abstract
Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to health. Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline. Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease. Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers, but findings from trials have been mixed, which probably emphasises the fact that supplementation will confer benefit only if intake of a nutrient is inadequate. Supplementation of people who already have adequate intake with additional selenium might increase their risk of type-2 diabetes. The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional selenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenium supplements.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The strategy of Se biofortification of food crops is practiced in Se-deficient regions by adding inorganic Se-containing fertilizers to soils, e.g., in Finland [26,27], UK [28,29], and New Zealand [30], or by adding organic sources of Se to soils, e.g., in the USA [23].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [29]
In the citing paper
“A European randomized trial which was not included in this analysis suggests that the clinical effect of a combination of antioxidants is already apparent after five days of administration (287).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [287]
In the citing paper
“Observational studies revealed that both high and low intake of Se is associated with an increased risk of cardiovascular disease (Rayman 2012).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rayman 2012
Citations
Cites
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Self-citationEffects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Characterization of Mammalian Selenoproteomes
Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,385
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330
Dual Function of the Selenoprotein PHGPx During Sperm Maturation
Ursini, F., Heim, S., Kieß, M., Maiorino, M., Roveri, A., Wissing, J. B., & Flohé, L. (1999) · Science · doi:10.1126/science.285.5432.1393 · Cited by 902
Selenium in cancer prevention: a review of the evidence and mechanism of action
Rayman, M. P. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005467 · Cited by 858
Self-citationFood-chain selenium and human health: emphasis on intake
Rayman, M. P. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508939830 · Cited by 798
Self-citationEffects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes
Stranges, S., Marshall, J. R., Natarajan, R., Donahue, R. P., Trevisan, M., Combs, G. F., Cappuccio, F. P., Ceriello, A., & Reid, M. E. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-4-200708210-00175 · Cited by 715
Cited by
Sorted by citations
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Heavy metal hyperaccumulating plants: how and why do they do it? And what makes them so interesting
Rascio, N., & Navari-Izzo, F. (2011) · Plant Science · doi:10.1016/j.plantsci.2010.08.016 · Cited by 2,012
Selenoproteins: Molecular Pathways and Physiological Roles
Labunskyy, V. M., Hatfield, D. L., & Gladyshev, V. N. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2013 · Cited by 1,452
Potential interventions for novel coronavirus in China: A systematic review
Zhang, L., & Liu, Y. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25707 · Cited by 1,377
Metadata
- Authors
- Rayman, M. P.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- Rayman, Margaret P
- ORCID
- Rayman, Margaret P
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 379
- Issue
- 9822
- Pages
- 1256-1268
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2013131201
- Cited by
- 3,563
- References
- 136
- Citations by year
- 2026: 305 · 2025: 334 · 2024: 310 · 2023: 339 · 2022: 369 · 2021: 337 · 2020: 311 · 2019: 221 · 2018: 199 · 2017: 173 · 2016: 187 · 2015: 153 · 2014: 158 · 2013: 120 · 2012: 33
- FWCI
- 137.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- selenium, selenoproteins, selenium status, selenium supplementation, antioxidant activity, thyroid hormones, immune function, cognitive decline, antiviral activity, reproductive health, autoimmune thyroid disease, cancer risk, type 2 diabetes, U-shaped dose-response
- MeSH terms
- Adult, Animals, Cause of Death, Cross-Cultural Comparison, Female, Humans, Immunocompetence, Longitudinal Studies, Male, Middle Aged, Neoplasms, Nutritional Requirements, Reference Values, Selenium, Survival Rate, Proportional Hazards Models, Selenoproteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
