The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
Open accessAbstract
Antiretroviral therapy for HIV infection requires life-long access and strict adherence to regimens that are both expensive and associated with toxicities. There is growing recognition that a curative intervention will be needed to fully stop the epidemic. The failure to eradicate HIV infection during long-term antiretroviral therapy reflects the intrinsic stability of the viral genome in latently infected CD4+ T cells and other cells and perhaps ongoing low-level viral replication. Heterogeneity in latently infected cell populations and homeostatic proliferation of infected cells may influence the dynamics of virus production and persistence. Chronic immune activation, inflammation and immune dysfunction persist despite potent antiretroviral therapy and likely have important effects on the size and distribution of the viral reservoir. The inability of the immune system to recognize cells harboring latent virus and to eliminate cells actively producing virus represents the biggest challenge to finding a cure. In this perspective, we highlight new approaches toward unraveling the complex virus-host interactions that lead to persistent infection and latency and discuss the rationale for combining novel therapeutic strategies with current antiretroviral treatment options with the goal of curing HIV disease.
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Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Self-citationUpregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
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. Plasma levels of soluble CD14 independently predict mortality in HIV infection.
Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq118 · Cited by 1,106
Self-citationA novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
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Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
Karn, J., & Stoltzfus, C. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006916 · Cited by 437
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Cited by
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Ho, Y.-C., Shan, L., Hosmane, N. N., Wang, J., Laskey, S. B., Rosenbloom, D. I. S., Lai, J., Blankson, J. N., Siliciano, J. D., & Siliciano, R. F. (2013) · Cell · doi:10.1016/j.cell.2013.09.020 · Cited by 1,405
Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3781 · Cited by 477
HIV-1 persistence in CD4+ T cells with stem cell–like properties
Buzon, M. J., Sun, H., Li, C., Shaw, A., Seiss, K., Ouyang, Z., Martin-Gayo, E., Leng, J., Henrich, T. J., Li, J. Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3445 · Cited by 414
HIV persists throughout deep tissues with repopulation from multiple anatomical sources
Chaillon, A., Gianella, S., Dellicour, S., Rawlings, S. A., Schlub, T. E., De Oliveira, M. F., Ignacio, C., Porrachia, M., Vrancken, B., & Smith, D. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134815 · Cited by 250
Microbiota and Probiotics in Health and HIV Infection
D’Angelo, C., Reale, M., & Costantini, E. (2017) · Nutrients · doi:10.3390/nu9060615 · Cited by 97
Metadata
- Authors
- Katlama, C., Deeks, S. G., Autran, B., Martinez-Picado, J., van Lunzen, J., Rouzioux, C., Miller, M., Vella, S., Schmitz, J. E., Ahlers, J., Richman, D. D., & Sekaly, R. P.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 381
- Issue
- 9883
- Pages
- 2109-2117
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2123063882
- Cited by
- 295
- References
- 7
- FWCI
- 20.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Katlama, C., Deeks, S. G., Autran, B., Martinez-Picado, J., van Lunzen, J., Rouzioux, C., Miller, M., Vella, S., Schmitz, J. E., Ahlers, J., Richman, D. D., & Sekaly, R. P. (2013). Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. The Lancet. https://doi.org/10.1016/s0140-6736(13)60104-x
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