The stress of life: a modern complaint?
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Under chronic stress, brain nerve impulses continuously activate the hypothalamus to produce CRF, which stimulates pituitary cells to release ACTH, which promotes synthesis of corticosteroids.
“Under chronic stress, the brain's nerve impulses can continuously activate the hypothalamus to produce the corticotropin-releasing factor (CRF). CRF is transported through the blood to the pituitary gland, thereby stimulating cells to release the adrenocorticotropic hormone (ACTH), which travels through the blood to the adrenal cortex and promotes the synthesis of corticosteroids.”
From Chronic Stress Promotes Cancer Development (2020) · cites this paper as [1]
The section “The stress of life: a modern complaint?” (p. 1) links stress reactions to the hypothalamic-pituitary-adrenal axis and mentions hypothalamic releasing factors. It does not describe continuous activation under chronic stress or the claimed CRF → ACTH → corticosteroid sequence. (LLM, conf=0.83)
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- Authors
- Jackson, M.
- Affiliations
- University of Exeter (GB)
- Corresponding author
- Jackson, Mark
- ORCID
- Jackson, Mark
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 383
- Issue
- 9914
- Pages
- 300-301
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC4306016
- OpenAlex
- W2050702976
- Cited by
- 55
- References
- 5
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (085433)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Utopian, Dystopian, and Speculative Fiction
- Social Sciences › Arts and Humanities › Literature and Literary Theory › Contemporary Literature and Criticism
- Social Sciences › Arts and Humanities › Literature and Literary Theory › Modernist Literature and Criticism
- Keywords
- J. G. Ballard, apocalyptic fiction, stress, modernity, work, wealth, leisure, middle class, violence, madness, dystopian novel
- MeSH terms
- Mental Disorders, Humans, Medicine in Literature, Stress, Psychological, History, 19th Century, History, 20th Century, History, 21st Century
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