Gene Expression Profiling Reveals Candidate Biomarkers and Probable Molecular Mechanisms in Chronic Stress
Open accessAbstract
Chronic stress refers to nonspecific systemic reactions under the over-stimulation of different external and internal factors for a long time. Previous studies confirmed that chronic psychological stress had a negative effect on almost all tissues and organs. We intended to further identify potential gene targets related to the pathogenesis of chronic stress-induced consequences involved in different diseases. In our study, mice in the model group lived under the condition of chronic unpredictable mild stress (CUMS) until they expressed behaviors like depression which were supposed to undergo chronic stress. We applied high-throughput RNA sequencing to assess mRNA expression and obtained transcription profiles in lung tissue from CUMS mice and control mice for analysis. In view of the prediction of high-throughput RNA sequences and bioinformatics software, and mRNA regulatory network was constructed. First, we conducted differentially expressed genes (DEGs) and obtained 282 DEGs between CUMS (group A) and the control model (group B). Then, we conducted functional and pathway enrichment analyses. In general, the function of upregulated regulated DEGs is related to immune and inflammatory responses. PPI network identified several essential genes, of which ten hub genes were related to the T cell receptor signaling pathway. qRT-PCR results verified the regulatory network of mRNA. The expressions of CD28, CD3e, and CD247 increased in mice with CUMS compared with that in control. This illustrated immune pathways are related to the pathological molecular mechanism of chronic stress and may provide information for identifying potential biomarkers and early detection of chronic stress.
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Chronic stress is linked with higher levels of Th1 cells in individuals carrying specific minor alleles of the glucocorticoid receptor and interferon-gamma receptor genes.
“The results showed that chronic stress is linked with higher levels of Th1 cells in individuals carrying specific minor alleles of the glucocorticoid receptor and interferon-gamma receptor genes.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [27]
There is a genetic predisposition to stress-induced immune dysregulation.
“This indicates a genetic predisposition to stress-induced immune dysregulation [13,27,62].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [27]
NPY inhibits the sympathetic system and activates the parasympathetic system, reducing thermogenesis and facilitating nutrient digestion and storage.
“Additionally, NPY inhibits the sympathetic system and activates the parasympathetic system, reducing thermogenesis and facilitating nutrient digestion and storage [27,66].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [27]
CRH can acutely induce anorexia, while NPY stimulates CRH secretion via Y1 receptors, counter-regulating its own effects.
“Corticotropin-releasing hormone (CRH) can acutely induce anorexia, while NPY stimulates CRH secretion via Y1 receptors, counter-regulating its own effects.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [27]
Stress influences appetite regulation by affecting the central appetite/satiety centers in the hypothalamus.
“Stress influences appetite regulation by affecting the central appetite/satiety centers in the hypothalamus.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [27]
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Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
HISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
STRING v10: protein–protein interaction networks, integrated over the tree of life
Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K., Heller, D., Huerta-Cepas, J., Simonovic, M., Roth, A., Santos, A., Tsafou, K. P., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1003 · Cited by 10,436 · see citing works
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327 · see citing works
The impact of stress on body function: a review
Yaribeygi, H., Panahi, Y., Sahraei, H., Johnston, T. P., & Sahebkar, A. (2017) · EXCLI journal · doi:10.17179/excli2017-480 · Cited by 1,095 · see citing works
Sucrose preference test for measurement of stress-induced anhedonia in mice
Liu, M.-Y., Yin, C.-Y., Zhu, L.-J., Zhu, X.-H., Xu, C., Luo, C.-X., Chen, H., Zhu, D.-Y., & Zhou, Q.-G. (2018) · Nature Protocols · doi:10.1038/s41596-018-0011-z · Cited by 1,026 · see citing works
Irving, B. A., & Weiss, A. (1991) · Cell · doi:10.1016/0092-8674(91)90314-o · Cited by 806 · see citing works
Antoniuk, S., Bijata, M., Ponimaskin, E., & Wlodarczyk, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.002 · Cited by 750 · see citing works
Kumar, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01722 · Cited by 699 · see citing works
Chronic Stress Promotes Cancer Development
Dai, S., Mo, Y., Wang, Y., Xiang, B., Liao, Q., Zhou, M., Li, X., Li, Y., Xiong, W., Li, G., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01492 · Cited by 405 · see citing works
Self-citationGenome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Spanish Scleroderma Group, Radstake, T. R. D. J., Gorlova, O. Y., Rueda‐Medina, B., Martín, J., Alizadeh, B. Z., Palomino‐Morales, R., Coenen, M. J. H., Vonk, M. C., Voskuyl, A. E., et al. (2010) · Nature Genetics · doi:10.1038/ng.565 · Cited by 400 · see citing works
Life event, stress and illness.
Salleh, M. R. (2008) · Europe PMC (PubMed Central) · Cited by 371 · see citing works
TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response
Baniyash, M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1434 · Cited by 346 · see citing works
Reiche, E. M. V., Morimoto, H. K., & Nunes, S. M. V. (2005) · International Review of Psychiatry · doi:10.1080/02646830500382102 · Cited by 214 · see citing works
Banerjee, A., Herring, C. A., Chen, B., Kim, H., Simmons, A. J., Southard-Smith, A. N., Allaman, M. M., White, J. R., Macedonia, M. C., McKinley, E. T., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.08.029 · Cited by 213 · see citing works
NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice
Song, A., Gao, B., Fan, J.-J., Zhu, Y., Zhou, J., Wang, Y., Xu, L.-Z., & Wu, W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01848-8 · Cited by 208 · see citing works
LungMAP: The Molecular Atlas of Lung Development Program
Ardini, M.-A., Clark, R. F., Ansong, C. K., Carson, J. P., CORLEY, R. A., Deutsch, G. H., Hagood, J. S., Kaminski, N., Mariani, T. J., Potter, S. S., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00139.2017 · Cited by 206 · see citing works
Wang, A., Chiou, J., Poirion, O., Buchanan, J., Valdez, M. J., Verheyden, J. M., Hou, X., Kudtarkar, P., Narendra, S., Newsome, J. M., et al. (2020) · eLife · doi:10.7554/elife.62522 · Cited by 201 · see citing works
Chronic stress: a critical risk factor for atherosclerosis
Yao, B.-C., Meng, L., Hao, M.-L., Zhang, Y.-M., Gong, T., & Guo, Z. (2019) · Journal of International Medical Research · doi:10.1177/0300060519826820 · Cited by 158 · see citing works
Gorrotxategi, M. P., Munitis, A. E., Santamaría, M. D., & Ozamiz-Etxebarria, N. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.05.022 · Cited by 155 · see citing works
Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)
Kakleas, K., Soldatou, A., Karachaliou, F., & Karavanaki, K. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.05.002 · Cited by 150 · see citing works
Chen, H., Liu, D., Guo, L., Cheng, X., Guo, N., & Shi, M. (2017) · The Journal of Pathology · doi:10.1002/path.4988 · Cited by 143 · see citing works
Lee, S., Suh, G. Y., Ryter, S. W., & Choi, A. M. K. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0231tr · Cited by 129 · see citing works
Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron
Saeedi, M., & Rashidy‐Pour, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110995 · Cited by 117 · see citing works
Huang, H.-J., Zhu, X.-C., Han, Q.-Q., Wang, Y.-L., Yue, N., Wang, J., Yu, R., Li, B., Wu, G.-C., Liu, Q., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.040 · Cited by 114 · see citing works
Molecular mechanisms for the assembly of the T cell receptor–CD3 complex
Call, M. E., & Wucherpfennig, K. W. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2003.11.017 · Cited by 111 · see citing works
Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo
Liu, L., Dong, Y. J., Shan, X., Li, L., Xia, B., & Wang, H. (2019) · Molecules · doi:10.3390/molecules24020326 · Cited by 110 · see citing works
Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway
Pan, J., Ju, D., Wang, Q., Zhang, M., Xia, D., Zhang, L., Yu, H. C., & Cao, X. (2001) · Immunology Letters · doi:10.1016/s0165-2478(01)00183-3 · Cited by 96 · see citing works
Benonisson, H., Altıntaş, I., Sluijter, M., Verploegen, S. A. B. W., Labrijn, A. F., Schuurhuis, D. H., Houtkamp, M., Verbeek, J. S., Schuurman, J., & van Hall, T. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0679 · Cited by 96 · see citing works
Zhang, L., Pan, J., Chen, W., Jiang, J., & Huang, J. (2020) · PubMed Central · Cited by 93 · see citing works
Self-citationRosenne, E., Sorski, L., Shaashua, L., Neeman, E., Matzner, P., Levi, B. Z., & Ben‐Eliyahu, S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.007 · Cited by 86 · see citing works
Chronic stress dysregulates amygdalar output to the prefrontal cortex
Lowery-Gionta, E. G., Crowley, N. A., Bukalo, O., Silverstein, S., Holmes, A., & Kash, T. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.032 · Cited by 84 · see citing works
Chronic Unpredictable Mild Stress in Rats Induces Colonic Inflammation
Wei, L., Li, Y., Tang, W., Sun, Q., Chen, L., Wang, X., Liu, Q., Yu, S., Yu, S., Liu, C., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01228 · Cited by 83 · see citing works
Self-citationA T-cell–engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer
Iizuka, A., Nonomura, C., Ashizawa, T., Kondou, R., Ohshima, K., Sugino, T., Mitsuya, K., Hayashi, N., Nakasu, Y., Maruyama, K., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3123 · Cited by 77 · see citing works
The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice.
Huang, H.-J., Chen, X.-R., Han, Q.-Q., Wang, J., Pilot, A., Yu, R., Liu, Q., Li, B., Wu, G.-C., Wang, Y.-Q., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.013 · Cited by 74 · see citing works
Gorman, C., Russell, A. I., Zhang, Z., Graham, D. S. C., Cope, A. P., & Vyse, T. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.1060 · Cited by 63 · see citing works
The stress of life: a modern complaint?
Jackson, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60093-3 · Cited by 55 · see citing works
Ilich, J. Z., Gilman, J. C., Cvijetić, S., & Boschiero, D. (2020) · Nutrients · doi:10.3390/nu12040989 · Cited by 51 · see citing works
Zhu, Y., Li, S.-L., Zhu, C., Wang, W., Zuo, W.-F., & Qiu, X. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112832 · Cited by 49 · see citing works
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19
Parkinson, N., Rodgers, N., Fourman, M. H., Wang, B., Zechner, M., Swets, M. C., Millar, J. E., Law, A. S., Russell, C. D., Baillie, J. K., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-79033-3 · Cited by 46 · see citing works
Down Regulation of T Cell Receptor Expression in COPD Pulmonary CD8 Cells
Grundy, S., Plumb, J., Lea, S., Kaur, M., Ray, D. W., & Singh, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071629 · Cited by 45 · see citing works
Taylor, W. D., & Blackford, J. U. (2020) · Annals of Internal Medicine · doi:10.7326/m20-2440 · Cited by 45 · see citing works
Luo, L., Zhou, W., Cai, J.-J., Feng, M., Zhou, M., Hu, S., Xu, J., & Ji, L. (2017) · Journal of Diabetes Research · doi:10.1155/2017/8103904 · Cited by 44 · see citing works
Screening of Key Genes of Sepsis and Septic Shock Using Bioinformatics Analysis
Zeng, X., Feng, J., Yang, Y., Zhao, R., Yu, Q., Qin, H., Wei, L., Ji, P., Li, H., Wu, Z., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s301663 · Cited by 37 · see citing works
CD3 ζ defects in systemic lupus erythematosus
Takeuchi, T., Suzuki, K., Kondo, T., Yoshimoto, K., & Tsuzaka, K. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200641 · Cited by 32 · see citing works
Eldor, R., Klieger, Y., Sade-Feldman, M., Vaknin, I., Varfolomeev, I., Fuchs, C., & Baniyash, M. (2014) · Diabetes Care · doi:10.2337/dc14-1544 · Cited by 29 · see citing works
Li, Y., Chen, S., Li, X., Wang, X., Li, H., Ning, S., & Chen, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.762594 · Cited by 29 · see citing works
Self-citationAutophagy in chronic stress induced atherosclerosis
Li, N., Zhang, R., Xie, X., & Gu, H. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.01.006 · Cited by 26 · see citing works
Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease
Lahdenperä, A. I., Fälth‐Magnusson, K., Högberg, L., Ludvigsson, J., & Vaarala, O. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.863966 · Cited by 25 · see citing works
Liu, Y., Wu, Y., Zhang, P., Xu, C., Liu, Z., He, C., Liu, Y.-M., & Kang, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.636870 · Cited by 22 · see citing works
Chronic stress accelerates the process of gastric precancerous lesions in rats
Zheng, J., Cai, W.-W., Lu, X., He, W., Li, D., Zhong, H., Yang, L., Li, S., Li, H., Rafee, S., et al. (2021) · Journal of Cancer · doi:10.7150/jca.52658 · Cited by 22 · see citing works
Application of mindfulness techniques in patients with asthma or COPD
López-Lois, B., González‐Barcala, F. J., & Facal-Mayo, D. (2020) · Journal of Asthma · doi:10.1080/02770903.2020.1776729 · Cited by 21 · see citing works
Crammed signaling motifs in the T-cell receptor
Borroto, A., Abia, D., & Alarcón, B. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.05.007 · Cited by 20 · see citing works
Vlasakakis, G., Napolitano, A., Barnard, R. M., Brown, K., Bullman, J., Inman, D. R., Keymeulen, B., Lanham, D., Leirens, Q., MacDonald, A., et al. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13842 · Cited by 13 · see citing works
Psychological morbidity in interstitial lung disease: a study from India
Rajpoot, A., Garg, K., Saini, V., & Gupta, N. (2020) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2020.1434 · Cited by 12 · see citing works
Feng, X., Zhao, C., Li, L., Feng, J., He, W., Shi, T., Li, N., Jie, Z., & Su, X. (2020) · European Journal of Immunology · doi:10.1002/eji.202048798 · Cited by 11 · see citing works
T cell activation deficiencies
Deist, F. L., Hivroz, C., Partiseti, M., Rieux‐Laucat, F., Debatin, K., Choquet, D., de Villartay, J., & Fischer, A. (1995) · Clinical Immunology and Immunopathology · doi:10.1016/s0090-1229(95)90072-1 · Cited by 8 · see citing works
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Shchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73 · see citing works
Psychological stress: neuroimmune roles in periodontal disease
Zhang, J., Lin, S., Luo, L., Zhang, Q., Jiao, Y., & Liu, W. (2022) · Odontology · doi:10.1007/s10266-022-00768-8 · Cited by 36 · see citing works
Wang, J., Ma, S., Li, L., Chen, Y., Yang, Q., Wang, F., Zheng, M., Miao, S., & Shi, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.983821 · Cited by 10 · see citing works
Liang, P., Wu, Y., Qu, S., Younis, M., Wang, W. J., Wu, Z., & Huang, X. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-023-08883-9 · Cited by 8 · see citing works
Yılmaz, V. (2025) · Biomedical Research and Therapy · doi:10.15419/j6ymbt60 · Cited by 1 · see citing works
Liang, P., Wu, Y., Qu, S., Younis, M., Wang, W., Wu, Z., & Huang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26658988
Liang, P., Wu, Y., Qu, S., Younis, M., Wang, W., Wu, Z., & Huang, X. (2024) · Figshare · doi:10.6084/m9.figshare.24934175
Liang, P., Wu, Y., Qu, S., Younis, M., Wang, W., Wu, Z., & Huang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26658985
Liang, P., Wu, Y., Qu, S., Younis, M., Wang, W., Wu, Z., & Huang, X. (2024) · Figshare · doi:10.6084/m9.figshare.24934650
Zheng, M., Huang, P., Wu, R., Wang, H., Xu, P., & Zheng, X. (2026) · Medicine · doi:10.1097/md.0000000000049113
- Authors
- Zhang, B., Zhong, W., Yang, B., Li, Y., Duan, S., Huang, J., & Mao, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Corresponding author
- Mao, Yanfei
- Venue
- Bioengineered
- Publisher
- Informa UK Limited
- Published
- 2022-02-19
- Volume
- 13
- Issue
- 3
- Pages
- 6048-6060
- ISSN
- 2165-5979 (ISSN-L)
- 2165-5987
- PMC
- PMC8973686
- OpenAlex
- W4212874344
- Cited by
- 6
- References
- 60
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bioengineered (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Figshare (cc-by)
- Funders
- National Natural Science Foundation of China (81772108)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
- Keywords
- chronic stress, chronic unpredictable mild stress, depression, lung transcriptome, differentially expressed genes, hub genes, T cell receptor signaling, immune response, inflammation, biomarkers, CD28, CD3ε, CD247
- MeSH terms
- Animals, RNA, Messenger, Biomarkers, Computational Biology, Gene Expression Profiling, Mice, Gene Regulatory Networks
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