Zika virus and microcephaly: why is this situation a PHEIC?
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The ICR suckling mice model is susceptible to ZIKV infection by both intraperitoneal and intracerebral injection and provides infection with high viral loads in the brain, consistent with severe neurological symptoms in humans.
“The ICR suckling mice model is susceptible for ZIKV infection by using both i.p. and i.c. injection methods and provide infection with high viral loads in the brain, which is consistent with severe neurological symptom in human [12, 14, 25].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [12]
The paper’s main text (page unavailable) reports clusters of neurological disorders occurring alongside Zika outbreaks, which supports the claim’s human neurological context. It calls for development of an animal model but does not report experiments in ICR suckling mice, either injection method, or viral loads in the brain; it also treats a causal link between Zika and the human disorders as unresolved. (LLM, conf=0.86)
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Cites
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Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
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Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
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Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice
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ICR suckling mouse model of Zika virus infection for disease modeling and drug validation
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- Authors
- Heymann, D. L., Hodgson, A., Sall, A. A., Freedman, D. O., Staples, J. E., Althabe, F., Baruah, K., Mahmud, G., Kandun, N., Vasconcelos, P. F. C., Bino, S., & Menon, K. U.
- Affiliations
- Chatham House (GB)
- Ghana Health Service (GH)
- Institut Pasteur de Dakar (SN)
- University of Alabama at Birmingham (US)
- Centers for Disease Control and Prevention (US)
- Instituto de Efectividad Clínica y Sanitaria (AR)
- Government of India (IN)
- Quaid-i-Azam University (PK)
- Kementerian Kesehatan Republik Indonesia (ID)
- Institute of Public Health (AL)
- Ministry of Communications and Information (SG)
- Corresponding author
- Heymann, David L
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 387
- Issue
- 10020
- Pages
- 719-721
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7134564
- OpenAlex
- W2272004514
- Cited by
- 415
- References
- 9
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 41 · 2022: 25 · 2021: 47 · 2020: 38 · 2019: 39 · 2018: 60 · 2017: 59 · 2016: 88
- FWCI
- 81.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- Zika virus, microcephaly, public health emergency of international concern, International Health Regulations, neurological disorders, emerging infectious diseases
- MeSH terms
- Zika Virus Infection, Emergencies, Humans, Microcephaly, Public Health, Global Health, World Health Organization
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