Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
Open accessAbstract
The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. However, information about the underlying molecular and cellular mechanisms connecting viral infection to these defects remains limited. In this study we have examined the expression of receptors implicated in cell entry of several enveloped viruses including ZIKV across diverse cell types in the developing brain. Using single-cell RNA-seq and immunohistochemistry, we found that the candidate viral entry receptor AXL is highly expressed by human radial glial cells, astrocytes, endothelial cells, and microglia in developing human cortex and by progenitor cells in developing retina. We also show that AXL expression in radial glia is conserved in developing mouse and ferret cortex and in human stem cell-derived cerebral organoids, highlighting multiple experimental systems that could be applied to study mechanisms of ZIKV infectivity and effects on brain development.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Single-cell RNA-seq of human primary tissue showed that the candidate viral entry receptor AXL is highly expressed by cortical radial glial cells, astrocytes, endothelial cells and microglia, and also by radial-glia-like cells of brain organoids.
“single-cell RNA-seq data from human primary tissue revealed that the candidate viral entry receptor, AXL (also known as tyrosine-protein kinase receptor UFO), is highly expressed by human cortical radial glial cells, astrocytes, endothelial cells, and microglia, as well as in radial-glia-like cells of brain organoids73.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [73]
Blocking the AXL receptor reduced Zika virus infection of PSC-derived astrocytes in vitro, and genetic knockdown of AXL in a glial cell line nearly abolished infection.
“Blocking the AXL receptor reduced ZIKV infection of PSC-derived astrocytes in vitro, and genetic knockdown of AXL in a glial cell line nearly abolished infection.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884 · see citing works
Zika Virus (I). Isolations and serological specificity
Dick, G. W. A., Kitchen, S. F., & Haddow, A. J. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90042-4 · Cited by 2,698 · see citing works
Zika Virus Infection in Pregnant Women in Rio de Janeiro
Brasil, P., Pereira, J. P., Moreira, M. E. L., Nogueira, R. M. R., Damasceno, L. S., Wakimoto, M. D., Rabello, R. S., Gaw, S. L., Halai, U., Salles, T. R. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602412 · Cited by 2,190 · see citing works
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016 · see citing works
Self-citationNeurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Self-citationZika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.02.016 · Cited by 1,292 · see citing works
Biology of Zika Virus Infection in Human Skin Cells
Hamel, R., Dejarnac, O., Wichit, S., Ekchariyawat, P., Neyret, A., Luplertlop, N., Perera-Lecoin, M., Surasombatpattana, P., Talignani, L., Frédéric Thomas, A., et al. (2015) · Journal of Virology · doi:10.1128/jvi.00354-15 · Cited by 1,199 · see citing works
Melo, A. S. O., Malinger, G., Ximenes, R., Szejnfeld, P. O., Sampaio, S. A., & de Filippis, A. M. B. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15831 · Cited by 1,180 · see citing works
Calvet, G. A., Aguiar, R. S., Melo, A., Sampaio, S. A., de Filippis, I., Fabri, A. D. A., de Araújo, E. S. M., de Sequeira, P. C., de Mendonça, M. C. L., de Oliveira, L., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00095-5 · Cited by 1,164 · see citing works
A developmental and genetic classification for malformations of cortical development: update 2012
Barkovich, A. J., Guerrini, R., Kuzniecky, R., Jackson, G. D., & Dobyns, W. B. (2012) · Brain · doi:10.1093/brain/aws019 · Cited by 1,110 · see citing works
Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015
Schüler‐Faccini, L., Ribeiro, E. M., Feitosa, I. M. L., Horovitz, D. D. G., Cavalcanti, D. P., Pessoa, A. L. S., Doriqui, M. J. R., Neri, J. I., Neto, J. M. D. P., Wanderley, H. Y. C., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6503e2 · Cited by 1,076 · see citing works
The Outcome of Congenital Cytomegalovirus Infection in Relation to Maternal Antibody Status
Fowler, K. B., Stagno, S., Pass, R. F., Britt, W. J., Boll, T. J., & Alford, C. A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203053261003 · Cited by 1,075 · see citing works
TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response
Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. A., & Lemke, G. (2007) · Cell · doi:10.1016/j.cell.2007.10.034 · Cited by 1,055 · see citing works
Molecular Identity of Human Outer Radial Glia during Cortical Development
Pollen, A. A., Nowakowski, T. J., Chen, J., Retallack, H., Sandoval-Espinosa, C., Nicholas, C. R., Shuga, J., Liu, S. J., Oldham, M. C., Diaz, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.004 · Cited by 908 · see citing works
Self-citationOSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830 · see citing works
Zika virus (II). Pathogenicity and physical properties
Dick, G. W. A. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90043-6 · Cited by 690 · see citing works
Freitas, B. D. P., Dias, J. R. D. O., Prazeres, J. M. B., do Sacramento, G. A., Ko, A. I., Maia, M., & Belfort, R. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2016.0267 · Cited by 559 · see citing works
Sakaguchi, H., Kadoshima, T., Soen, M., Narii, N., Ishida, Y., Ohgushi, M., Takahashi, J., Eiraku, M., & Sasai, Y. (2015) · Nature Communications · doi:10.1038/ncomms9896 · Cited by 542 · see citing works
The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry
Meertens, L., Carnec, X., Perera-Lecoin, M., Ramdasi, R., Guivel‐Benhassine, F., Lew, E. D., Lemke, G., Schwartz, O., & Amara, A. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.009 · Cited by 526 · see citing works
Zika Virus Associated with Meningoencephalitis
Carteaux, G., Maquart, M., Bedet, A., Contou, D., Brugières, P., Fourati, S., de Langavant, L. C., de Broucker, T., Brun‐Buisson, C., Leparc-Goffart, I., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmc1602964 · Cited by 477 · see citing works
Woods, C. G., Bond, J., & Enard, W. (2005) · The American Journal of Human Genetics · doi:10.1086/429930 · Cited by 429 · see citing works
Martines, R. B., Bhatnagar, J., Keating, M. K., Silva-Flannery, L. M., Muehlenbachs, A., Gary, J. M., Goldsmith, C. S., Hale, G., Ritter, J. M., Rollin, D., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6506e1 · Cited by 416 · see citing works
Zika virus and microcephaly: why is this situation a PHEIC?
Heymann, D. L., Hodgson, A., Sall, A. A., Freedman, D. O., Staples, J. E., Althabe, F., Baruah, K., Mahmud, G., Kandun, N., Vasconcelos, P. F. C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00320-2 · Cited by 415 · see citing works
Acute myelitis due to Zika virus infection
Mécharles, S., Herrmann, C., Poullain, P., Tran, T.-H., Deschamps, N., Mathon, G., Landais, A. F., Breurec, S., & Lannuzel, A. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00644-9 · Cited by 350 · see citing works
Flavivirus Entry Receptors: An Update
Perera-Lecoin, M., Meertens, L., Carnec, X., & Amara, A. (2013) · Viruses · doi:10.3390/v6010069 · Cited by 324 · see citing works
G1 Phase Regulation, Area-Specific Cell Cycle Control, and Cytoarchitectonics in the Primate Cortex
Lukaszewicz, A., Savatier, P., Cortay, V., Giroud, P., Huissoud, C., Berland, M., Kennedy, H., & Dehay, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.032 · Cited by 315 · see citing works
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
Lizarraga, S. B., Margossian, S. P., Harris, M. H., Campagna, D. R., Han, A., Blevins, S., Mudbhary, R., Barker, J. E., Walsh, C. A., & Fleming, M. D. (2010) · Development · doi:10.1242/dev.040410 · Cited by 270 · see citing works
TAM receptors and the clearance of apoptotic cells
Lemke, G., & Burstyn‐Cohen, T. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05744.x · Cited by 244 · see citing works
Gruber, R., Zhou, Z., Sukchev, M., Jörß, T., Frappart, P., & Wang, Z. (2011) · Nature Cell Biology · doi:10.1038/ncb2342 · Cited by 236 · see citing works
Gérardin, P., Sampériz, S., Ramful, D., Boumahni, B., Bintner, M., Alessandri, J., Carbonnier, M., Tiran-Rajaofera, I., Beullier, G., Boya, I., et al. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002996 · Cited by 229 · see citing works
Diagnostic approach to microcephaly in childhood: a two‐center study and review of the literature
von der Hagen, M., Pivarcsi, M., Liebe, J., et al. (2014) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12425 · Cited by 227 · see citing works
Zika virus infection of the central nervous system of mice
Bell, T., Field, E. J., & Narang, H. K. (1971) · Archives of Virology · doi:10.1007/bf01249709 · Cited by 213 · see citing works
Birth Outcomes Following West Nile Virus Infection of Pregnant Women in the United States: 2003-2004
O’Leary, D. R., Kuhn, S., Kniss, K. L., Hinckley, A. F., Rasmussen, S. A., Pape, W. J., Kightlinger, L. K., Beecham, B. D., Miller, T. K., Neitzel, D. F., et al. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2024 · Cited by 213 · see citing works
Cytomegalovirus-Induced Brain Malformations in Fetuses
Teissier, N., Fallet‐Bianco, C., Delezoide, A., Laquerrière, A., Marcorelles, P., Khung‐Savatovsky, S., Nardelli, J., Cipriani, S., Csaba, Z., Picone, O., et al. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000038 · Cited by 155 · see citing works
Miner, J. J., Daniels, B. P., Shrestha, B., Proenca-Modena, J. L., Lew, E. D., Lazear, H. M., Gorman, M. J., Lemke, G., Klein, R. S., & Diamond, M. S. (2015) · Nature Medicine · doi:10.1038/nm.3974 · Cited by 152 · see citing works
Conboy, T. J., Pass, R. F., Stagno, S., Britt, W. J., Alford, C. A., McFarland, C. E., & Boll, T. J. (1986) · PEDIATRICS · doi:10.1542/peds.77.6.801 · Cited by 115 · see citing works
Control of Outer Radial Glial Stem Cell Mitosis in the Human Brain
Ostrem, B. E. L., Lui, J. H., Gertz, C. C., & Kriegstein, A. R. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.058 · Cited by 112 · see citing works
Self-citationTAM Receptors Affect Adult Brain Neurogenesis by Negative Regulation of Microglial Cell Activation
Ji, R., Tian, S., Lu, H. J., Lu, Q., Zheng, Y., Wang, X., Ding, J., Lu, Q., & Lu, Q. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302229 · Cited by 106 · see citing works
TAM Receptors Support Neural Stem Cell Survival, Proliferation and Neuronal Differentiation
Ji, R., Meng, L., Jiang, X. M., Naresh Kumar, C. V. M., Ding, J., Li, Q., & Lu, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115140 · Cited by 63 · see citing works
Neuroimaging in CMV congenital infected neonates: how and when
Lanari, M., Capretti, M. G., Lazzarotto, T., Gabrielli, L., Rizzollo, S., Mostert, M., & Manzoni, P. (2012) · Early Human Development · doi:10.1016/s0378-3782(12)70003-8 · Cited by 40 · see citing works
Transcriptome Analysis of Neural Progenitor Cells by a Genetic Dual Reporter Strategy
Wang, J., Zhang, H., Young, A. G., Qiu, R., Herculian, S., Li, X., Wu, X., Lemke, G., & Lü, Q. (2011) · Stem Cells · doi:10.1002/stem.699 · Cited by 32 · see citing works
Kawasaki, H., Kosugi, I., Sakao‐Suzuki, M., Meguro, S., Arai, Y., Tsutsui, Y., & Iwashita, T. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.01.032 · Cited by 28 · see citing works
Ahlfors, K., Ivarsson, S.-A., & Bjerre, I. (1986) · PEDIATRICS · doi:10.1542/peds.78.6.1058 · Cited by 23 · see citing works
Cytomegalovirus and Microcephaly
Nakao, T., & Chiba, S. (1970) · PEDIATRICS · doi:10.1542/peds.46.3.483 · Cited by 9 · see citing works
SINHA, S. K., Kaveggia, E. G., & GORDON, M. C. (1972) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1972.tb01579.x · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Azevedo, R. S. S., de Sousa, J. R., Araujo, M. T. F., Martins Filho, A. J., de Alcantara, B. N., Araujo, F. M. C., Queiroz, M. G. L., Cruz, A. C. R., Vasconcelos, B. H. B., Chiang, J. O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17765-5 · Cited by 3,478 · see citing works
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413 · see citing works
Cell diversity and network dynamics in photosensitive human brain organoids
Quadrato, G., Nguyen, T., Macosko, E. Z., Sherwood, J. L., Min Yang, S., Berger, D. R., Maria, N., Scholvin, J., Goldman, M., Kinney, J. P., et al. (2017) · Nature · doi:10.1038/nature22047 · Cited by 1,321 · see citing works
The Brazilian Zika virus strain causes birth defects in experimental models
Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., et al. (2016) · Nature · doi:10.1038/nature18296 · Cited by 1,326 · see citing works
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Nowakowski, T. J., Bhaduri, A., Pollen, A. A., Alvarado, B., Mostajo-Radji, M. A., Di Lullo, E., Haeussler, M., Sandoval-Espinosa, C., Liu, S. J., Velmeshev, D., et al. (2017) · Science · doi:10.1126/science.aap8809 · Cited by 964 · see citing works
Self-citationDisease modeling in stem cell-derived 3D organoid systems
Dutta, D., Heo, I., & Clevers, H. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.007 · Cited by 838 · see citing works
The use of brain organoids to investigate neural development and disease
Di Lullo, E., & Kriegstein, A. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.107 · Cited by 788 · see citing works
Self-citationZika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice
Li, C., Xu, D., Ye, Q., Hong, S., Jiang, Y., Liu, X., Zhang, N., Shi, L., Qin, C.-F., & Xu, Z. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.017 · Cited by 749 · see citing works
Dang, J., Tiwari, S. K., Lichinchi, G., Qin, Y., Patil, V. S., Eroshkin, A. M., & Rana, T. M. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.014 · Cited by 731 · see citing works
Bershteyn, M., Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Nene, A., Wynshaw-Boris, A., & Kriegstein, A. R. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.12.007 · Cited by 566 · see citing works
Self-citationZika virus cell tropism in the developing human brain and inhibition by azithromycin
Retallack, H., Di Lullo, E., Arias, C., Knopp, K. A., Laurie, M. T., Sandoval-Espinosa, C., Mancia Leon, W. R., Krencik, R., Ullian, E. M., Spatazza, J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618029113 · Cited by 506 · see citing works
Self-citationAxl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses
Meertens, L., Labeau, A., Dejarnac, O., Cipriani, S., Sinigaglia, L., Bonnet-Madin, L., Le Charpentier, T., Hafirassou, M. L., Zamborlini, A., Cao-Lormeau, V.-M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.045 · Cited by 450 · see citing works
Watanabe, M., Buth, J. E., Vishlaghi, N., de la Torre-Ubieta, L., Taxidis, J., Khakh, B. S., Coppola, G., Pearson, C. A., Yamauchi, K., Gong, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.047 · Cited by 401 · see citing works
Human tissues in a dish: The research and ethical implications of organoid technology
Bredenoord, A. L., Clevers, H., & Knoblich, J. A. (2017) · Science · doi:10.1126/science.aaf9414 · Cited by 334 · see citing works
Building Models of Brain Disorders with Three-Dimensional Organoids
Amin, N. D., & Paşca, S. P. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.007 · Cited by 312 · see citing works
Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation
Li, H., Saucedo-Cuevas, L., Regla-Nava, J. A., Chai, G., Sheets, N., Tang, W., Terskikh, A. V., Shresta, S., & Gleeson, J. G. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.005 · Cited by 293 · see citing works
Onorati, M., Li, Z., Liu, F., Sousa, A. M. M., Nakagawa, N., Li, M., Dell’Anno, M. T., Gulden, F. O., Pochareddy, S., Tebbenkamp, A. T. N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.038 · Cited by 292 · see citing works
Wu, K.-Y., Zuo, G.-L., Li, X.-F., Ye, Q., Deng, Y.-Q., Huang, X.-Y., Cao, W.-C., Qin, C.-F., & Luo, Z.-G. (2016) · Cell Research · doi:10.1038/cr.2016.58 · Cited by 283 · see citing works
Garber, C., Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J., & Klein, R. S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0427-y · Cited by 272 · see citing works
Wells, M. F., Salick, M. R., Wiskow, O., Ho, D. J., Worringer, K. A., Ihry, R. J., Kommineni, S., Bilican, B., Klim, J. R., Hill, E. J., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.11.011 · Cited by 269 · see citing works
Madore, C., Leyrolle, Q., Lacabanne, C., Benmamar-Badel, A., Joffre, C., Nadjar, A., & Layé, S. (2016) · Neural Plasticity · doi:10.1155/2016/3597209 · Cited by 141 · see citing works
Single cell transcriptomics in neuroscience: cell classification and beyond
Tasic, B. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.021 · Cited by 83 · see citing works
- Authors
- Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Sandoval-Espinosa, C., Bershteyn, M., & Kriegstein, A. R.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kriegstein, Arnold R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 18
- Issue
- 5
- Pages
- 591-596
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC4860115
- OpenAlex
- W2316180691
- Cited by
- 529
- References
- 45
- Citations by year
- 2026: 16 · 2025: 11 · 2024: 26 · 2023: 28 · 2022: 27 · 2021: 51 · 2020: 64 · 2019: 54 · 2018: 84 · 2017: 104 · 2016: 64
- FWCI
- 101.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Damon Runyon Cancer Research Foundation (DRG‐2166‐13)
- National Institutes of Health
- National Institute of Mental Health (U01MH105989)
- National Institute of Neurological Disorders and Stroke (R01NS035710, R01NS075998, R37NS035710)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Zika virus, AXL receptor, viral entry receptor, neural stem cells, radial glia, brain development, brain organoids, microcephaly, microglia, astrocytes, endothelial cells, single-cell RNA sequencing, mouse cortex
- MeSH terms
- Zika Virus, Axl Receptor Tyrosine Kinase, Animals, Blood Vessels, Cerebral Cortex, Disease Models, Animal, Ferrets, Neuroglia, Proto-Oncogene Proteins, Receptors, Virus, Receptor Protein-Tyrosine Kinases, Pluripotent Stem Cells, Mice, Virus Internalization, Neurogenesis, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
