The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Epilepsy in adults
Abstract
Epilepsy is one of the most common serious brain conditions, affecting over 70 million people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and older age groups. Progress in genomic technology is exposing the complex genetic architecture of the common types of epilepsy, and is driving a paradigm shift. Epilepsy is a symptom complex with multiple risk factors and a strong genetic predisposition rather than a condition with a single expression and cause. These advances have resulted in the new classification of epileptic seizures and epilepsies. A detailed clinical history and a reliable eyewitness account of a seizure are the cornerstones of the diagnosis. Ancillary investigations can help to determine cause and prognosis. Advances in brain imaging are helping to identify the structural and functional causes and consequences of the epilepsies. Comorbidities are increasingly recognised as important aetiological and prognostic markers. Antiseizure medication might suppress seizures in up to two-thirds of all individuals but do not alter long-term prognosis. Epilepsy surgery is the most effective way to achieve long-term seizure freedom in selected individuals with drug-resistant focal epilepsy, but it is probably not used enough. With improved understanding of the gradual development of epilepsy, epigenetic determinants, and pharmacogenomics comes the hope for better, disease-modifying, or even curative, pharmacological and non-pharmacological treatment strategies. Other developments are clinical implementation of seizure detection devices and new neuromodulation techniques, including responsive neural stimulation.
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Cites
ILAE official report: a practical clinical definition of epilepsy
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2018 ESC Guidelines for the diagnosis and management of syncope
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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
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The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
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Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome
Devinsky, O., Patel, A. D., Cross, J. H., Villanueva, V., Wirrell, E. C., Privitera, M., Greenwood, S. M., Roberts, C., Checketts, D., VanLandingham, K. E., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1714631 · Cited by 1,015
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Unifying the definitions of sudden unexpected death in epilepsy
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Cited by
Revisiting the role of neurotransmitters in epilepsy: An updated review
Akyuz, E., Polat, A. K., Eroglu, E., Kullu, I., Angelopoulou, E., & Paudel, Y. N. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118826 · Cited by 303
Microvascular stabilization via blood-brain barrier regulation prevents seizure activity
Greene, C., Hanley, N., Reschke, C. R., Reddy, A., Mäe, M. A., Connolly, R., Behan, C., O’Keeffe, E., Bolger, I., Hudson, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29657-y · Cited by 156
Bai, X., & Bian, Z. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.842288 · Cited by 66
Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy
Clarke, S., Karoly, P. J., Nurse, E., Seneviratne, U., Taylor, J., Knight-Sadler, R., Kerr, R., Moore, B., Hennessy, P., Mendis, D., et al. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106556 · Cited by 55
The role of Na+‐K+‐ATPase in the epileptic brain
Sun, J., Zheng, Y., Chen, Z., & Wang, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13893 · Cited by 55
Metadata
- Authors
- Thijs, R. D., Surges, R., O'Brien, T. J., & Sander, J. W.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 393
- Issue
- 10172
- Pages
- 689-701
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2911761011
- Cited by
- 2,183
- References
- 16
- FWCI
- 114.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thijs, R. D., Surges, R., O'Brien, T. J., & Sander, J. W. (2019). Epilepsy in adults. The Lancet. https://doi.org/10.1016/s0140-6736(18)32596-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
