Compartmental modeling of glucagon kinetics in the conscious dog
Abstract
The aim of the present study was to examine glucagon metabolism and distribution using both compartmental-modeling approaches and steady-state organ-balance techniques in conscious, overnight-fasted dogs. Arterial plasma glucose concentrations were clamped at 14 mmol/L with a variable exogenous glucose infusion. Somatostatin was infused to block endogenous secretion of insulin and glucagon. Insulin was replaced intraportally at 2.4 pmol.kg-1.min-1 to maintain basal insulin concentrations in the range from 70 +/- 4 to 95 +/- 12 pmol/L. Glucagon was not given during the control period, but was subsequently infused peripherally in four 1-hour steps of 1.0, 3.0, 6.0, and 3.0 ng.kg-1.min-1. Glucagon levels increased from 0 to 68 +/- 6, 195 +/- 19, 378 +/- 47, and 181 +/- 20 ng/mL. Compartmental analysis of glucagon concentrations showed that glucagon was distributed in one compartment with a volume approximately equal to the plasma volume. The metabolic clearance rate of glucagon was 17.6 mL.kg-1.min-1. The liver cleared 24% of glucagon, and the kidneys, 17%.
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Glucagon kinetics is a single compartment.
“Glucagon kinetics are described with a 1-compartment linear model 8 :”
From The UVA/PADOVA Type 1 Diabetes Simulator: New Features (2014) · cites this paper as [8]
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Self-citationGlucagon clearance is regulated by nutritional state: evidence from experimental studies in mice
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Self-citation
- Authors
- Dobbins, R. L., Davis, S. N., Neal, D. W., Cobelli, C., Jaspan, J., & Cherrington, A. D.
- Affiliations
- Tulane University (US)
- Corresponding author
- Cherrington, Alan D.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 44
- Issue
- 4
- Pages
- 452-459
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W1985847165
- Cited by
- 72
- References
- 46
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institutes of Health (5r01am018243-11, 5p60dk020593-31)
- National Institute of Diabetes and Digestive and Kidney Diseases (5P60 DK-20593)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- glucagon, compartmental modeling, metabolic clearance rate, somatostatin, insulin replacement therapy, glucose infusion, overnight fasting, conscious dogs
- MeSH terms
- Animals, Dogs, Female, Glucagon, Glucose, Insulin, Kinetics, Liver, Liver Circulation, Male, Models, Biological, Osmolar Concentration, Renal Circulation
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