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Cited by 229Head and Neck Cancer StudiesCancer, Hypoxia, and MetabolismRadiation Therapy and Dosimetry

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

Henk, J.M., Kunkler, P.B., Smith, C.W.·1977·The Lancet
DOI 10.1016/s0140-6736(77)90116-7
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Abstract

We report the results of a prospective controlled trial of the effect of hyperbaric oxygen as an adjuvant in radiotherapy of head and neck cancer. Patients were allocated randomly to treatment in oxygen or air. The radiotherapy in both groups was identical in planning, dose, and fractionation--i.e., 3500 rads in 10 fractions in 3 weeks. There was no difference in the survival rate between the two groups. However, significantly better local tumour control was seen in the hyperbaric-oxygen group, particularly in smaller lesions; there was significantly greater need for salvage surgery in the air group. Radiation effects on normal tissue appeared somewhat greater in the oxygen series, especially on laryngeal cartilage.

Overview

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Registry

Crossref · 10.1016/s0140-6736(77)90116-7

Cites

20 of 20 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 2

  1. Halnan, 1974, Proc. XI Int. Cancer Congr., 181
  2. Henk, 1976, Br. J. Radiol., 49, 1055

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Metadata

Authors
Henk, J. M., Kunkler, P. B., & Smith, C. W.
Affiliations
Velindre Cancer Centre (GB)
Venue
The Lancet
Publisher
Elsevier BV
Published
1977-07
Volume
310
Issue
8029
Pages
101-103
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(77)90116-7
OpenAlex
W2013729607
Cited by
229
References
20
Citations by year
2026: 4 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 7
FWCI
17.10
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords
hyperbaric oxygen therapy, head and neck cancer, radiotherapy, adjuvant therapy, local tumor control, salvage surgery, laryngeal cartilages, survival
MeSH terms
Carcinoma, Squamous Cell, Clinical Trials as Topic, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Laryngeal Neoplasms, Male, Mouth Neoplasms, Neoplasm Recurrence, Local, Nose Neoplasms, Pharyngeal Neoplasms, Prospective Studies, Radiotherapy Dosage

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