Cited by 229Head and Neck Cancer StudiesCancer, Hypoxia, and MetabolismRadiation Therapy and Dosimetry

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RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

Henk, J.M., Kunkler, P.B., Smith, C.W.·1977·The Lancet

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Abstract

We report the results of a prospective controlled trial of the effect of hyperbaric oxygen as an adjuvant in radiotherapy of head and neck cancer. Patients were allocated randomly to treatment in oxygen or air. The radiotherapy in both groups was identical in planning, dose, and fractionation--i.e., 3500 rads in 10 fractions in 3 weeks. There was no difference in the survival rate between the two groups. However, significantly better local tumour control was seen in the hyperbaric-oxygen group, particularly in smaller lesions; there was significantly greater need for salvage surgery in the air group. Radiation effects on normal tissue appeared somewhat greater in the oxygen series, especially on laryngeal cartilage.

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The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158
Clinical Radiation Pathology
Andrews, J. R., Rubin, P., & Casarett, G. W. (1968) · Radiation Research · doi:10.2307/3572601 · Cited by 916
Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data.
Peto, R., & Pike, M. C. (1973) · PubMed · Cited by 659
Dose, time and fractionation: A clinical hypothesis
Ellis, F. (1969) · Clinical Radiology · doi:10.1016/s0009-9260(69)80043-7 · Cited by 612
II. Clinical Application
Churchill‐Davidson, I., Sanger, C., & Thomlinson, R. H. (1957) · British Journal of Radiology · doi:10.1259/0007-1285-30-356-406 · Cited by 611
352. Note: Conservatism of the Approximation Σ(O - E) 2 /E in the Logrank Test for Survival Data or Tumor Incidence Data
Pető, R., & Pike, M. C. (1973) · Biometrics · doi:10.2307/2529177 · Cited by 507
RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER
Henk, J. M., & Smith, C. W. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90117-9 · Cited by 320
Self-citation
A Survival Curve for Mammalian Leukaemia Cells Irradiated 'in vivo (Implications for the Treatment of Mouse Leukaemia by Whole-Body Irradiation)
Hewitt, H. B., & Wilson, C. W. (1959) · British Journal of Cancer · doi:10.1038/bjc.1959.9 · Cited by 216
First results of a randomized clinical trial of fast neutrons compared with X or gamma rays in treatment of advanced tumours of the head and neck. Report to the Medical Research Council.
Catterall, M., Sutherland, I., & Bewley, D. K. (1975) · BMJ · doi:10.1136/bmj.2.5972.653 · Cited by 127
The effect of oxygen on cellular survival and recovery after radiation
Littbrand, B., & Révész, L. (1969) · British Journal of Radiology · doi:10.1259/0007-1285-42-504-914 · Cited by 123

Show all 20 references

Research works printed but not linked: 2

Halnan, 1974, Proc. XI Int. Cancer Congr., 181
Henk, 1976, Br. J. Radiol., 49, 1055

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Bennett, M. R., Feldmeier, J., Smee, R., & Milross, C. G. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.01.001 · Cited by 36
Dose-response relationships for human tumors: Implications for clinical trials of dose modifying agents
Williams, M. V., Denekamp, J., & Fowler, J. F. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90532-7 · Cited by 36
Misonidazole in fractionated radiotherapy: are many small fractions best?
Denekamp, J., McNally, N. J., Fowler, J. F., & Joiner, M. C. (1980) · British Journal of Radiology · doi:10.1259/0007-1285-53-634-981 · Cited by 36
Regaud lecture perspectives on the history of radiotherapy.
Fletcher, G. H. (1988) · PubMed · Cited by 36
Hypoxia Imaging Markers and Applications for Radiation Treatment Planning
Lin, A., & Hahn, S. M. (2012) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2012.04.002 · Cited by 34
The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia
Gallez, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.853568 · Cited by 35
Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas
Ogawa, K., Yoshii, Y., Inoue, O., Toita, T., Saitô, A., Kakinohana, Y., Adachi, G., Iraha, S., Tamaki, W., Sugimoto, K., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603342 · Cited by 34
Hyperbaric oxygen therapy
Coles, C., Williams, M., Burnet, N. G., Trytko, B., Bennett, M. R., Leach, R., & Wilmshurst, P. T. (1999) · BMJ · doi:10.1136/bmj.318.7190.1076c · Cited by 34
Increased radiosensitivity of tumors by perfluorochemicals and carbogen
Song, C. W., Zhang, W. L., Pence, D. M., Lee, I., & Levitt, S. H. (1985) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(85)90041-0 · Cited by 34
Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma
Hill, R. M., Rocha, S., & Parsons, J. L. (2022) · Cancers · doi:10.3390/cancers14174130 · Cited by 33
Old but new methods in radiation oncology: hyperbaric oxygen therapy
Ogawa, K., Kohshi, K., Ishiuchi, S., Matsushita, M., Yoshimi, N., & Murayama, S. (2013) · International Journal of Clinical Oncology · doi:10.1007/s10147-013-0537-6 · Cited by 33
The Effect of Therapy on Tumour Vascular Function
Chaplin, D. J. (1991) · International Journal of Radiation Biology · doi:10.1080/09553009114552071 · Cited by 33
Historic milestones in radiobiology and radiation therapy.
Kaplan, H. S. (1979) · PubMed · Cited by 32
The potential benefit from a perfect radiosensitizer and its dependence on reoxygenation
Denekamp, J., & Joiner, M. C. (1982) · British Journal of Radiology · doi:10.1259/0007-1285-55-657-657 · Cited by 31
Nasopharyngeal carcinoma: A review of cases treated by radiotherapy and chemotherapy
Khoury, G. G., & Paterson, I. C. (1987) · Clinical Radiology · doi:10.1016/s0009-9260(87)80387-2 · Cited by 31
Applications of hyperbaric oxygen for the otolaryngologist— head and neck surgeon
Nemiroff, P. M., & Rybak, L. P. (1988) · American Journal of Otolaryngology · doi:10.1016/s0196-0709(88)80008-5 · Cited by 30
The detection and modification of the hypoxic fraction in quiescent cell populations in murine solid tumours
Masunaga, S., Ono, K., & Abe, M. (1993) · British Journal of Radiology · doi:10.1259/0007-1285-66-790-918 · Cited by 30
Strategies to overcome accelerated repopulation and hypoxia—what have we learned from clinical trials?
Corry, J. F., & Rischin, D. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.09.005 · Cited by 29

Authors: Henk, J. M., Kunkler, P. B., & Smith, C. W.
Affiliations: Velindre Cancer Centre (GB)
Venue: The Lancet
Publisher: Elsevier BV
Published: 1977-07
Volume: 310
Issue: 8029
Pages: 101-103
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(77)90116-7
OpenAlex: W2013729607
Cited by: 229
References: 20
Citations by year: 2026: 4 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 17.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords: hyperbaric oxygen therapy, head and neck cancer, radiotherapy, adjuvant therapy, local tumor control, salvage surgery, laryngeal cartilages, survival
MeSH terms: Carcinoma, Squamous Cell, Clinical Trials as Topic, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Laryngeal Neoplasms, Male, Mouth Neoplasms, Neoplasm Recurrence, Local, Nose Neoplasms, Pharyngeal Neoplasms, Prospective Studies, Radiotherapy Dosage

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RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

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