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INCREASED RISK OF ISCHAEMIC HEART DISEASE IN SHIFT WORKERS
Abstract
504 papermill workers were followed up for 15 years and the incidence of ischaemic heart disease (IHD) in shift workers was compared with that in day workers. The relative risk (RR) of IHD rose with increasing duration of reported exposure to shift work. A significant risk of IHD was associated with an exposure of 11 - 15 years (RR = 2.2, p less than 0.04) and of 16 to 20 years (RR = 2.8, p less than 0.03. The association was independent of age and smoking history. The RR of IHD fell sharply after 20 years of shift work. This was ascribed to the pronounced positive selection that had taken place in this group.
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“Shift work is an independent risk factor for many chronic conditions, including heart disease (133-136), perhaps due to recurring disruptions of the circadian clock itself (e.g., light exposure at unusual circadian phases), or perhaps due to misalignment between the circadian clock and the behaviors (e.g., sleeping and fasting during the day, and being active and eating across the night).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [133]
In the citing paper
“shift work is associated with cardiovascular disease, obesity, and diabetes”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Knutsson et al., 1986
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Paciorek, M., Korczyński, P., Bielicki, P., Byśkiniewicz, K., Zielinski, J., & Chazan, R. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.06.013 · Cited by 46
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Bonham, M. P., Kaias, E., Zimberg, I. Z., Leung, G. K. W., Davis, R., Sletten, T. L., Windsor-Aubrey, H., & Huggins, C. E. (2019) · Journal of Biological Rhythms · doi:10.1177/0748730418824214 · Cited by 47
Metadata
- Authors
- Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1986-07
- Volume
- 328
- Issue
- 8498
- Pages
- 89-92
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2002254611
- Cited by
- 459
- References
- 19
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 20 · 2021: 11 · 2020: 12 · 2019: 15 · 2018: 12 · 2017: 13 · 2016: 10 · 2015: 16 · 2014: 18 · 2013: 20 · 2012: 21
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Keywords
- shift work, ischemic heart disease, cardiovascular risk, paper mill workers, exposure duration, selection bias, occupational health, smoking history
- MeSH terms
- Adult, Coronary Disease, Divorce, Follow-Up Studies, Humans, Industry, Male, Middle Aged, Occupational Diseases, Paper, Risk, Smoking, Sweden, Time Factors, Work, Work Schedule Tolerance
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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