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Cited by 385Bone health and osteoporosis researchVitamin D Research StudiesNutritional Studies and Diet

Dietary calcium and risk of hip fracture: 14-year prospective population study

Holbrook, TroyL., Barrett-Connor, Elizabeth, Wingard, DeborahL.·1988·The Lancet
DOI 10.1016/s0140-6736(88)90065-7
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Abstract

To assess the effect of dietary calcium intake on risk of hip fracture, a geographically defined caucasian population in southern California was studied prospectively. Between 1973 and 1975, a quantified 24 hour diet recall was obtained by a dietician from 957 men and women aged 50 to 79 years at baseline. Follow-up to 1987 with mortality records and interviews showed 15 men and 18 women with hip fractures. The age-adjusted risk of hip fracture was inversely associated with dietary calcium whether considered as mg per day or as nutrient density (mg per 1000 kcal). No other nutrient was consistently associated with hip fracture in any Cox proportional hazards model that included calcium. The association between calcium and fracture persisted after adjustment for cigarette smoking, alcohol intake, exercise, and obesity. The significant independent inverse association of dietary calcium with subsequent risk of hip fracture (relative risk = 0.6 per 198 mg/1000 kcal) strongly supports the hypothesis that increased dietary calcium intake protects against hip fracture.

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  • Lifestyle habits such as smoking, alcohol intake, little or no exercise, and inadequate calcium intake all influence calcium-vitamin D metabolism and bone mineral density, in some cases leading to osteoporosis, particularly in postmenopausal women.

    “Lifestyle habits, such as smoking, alcohol intake, little or no exercise, and an inadequate amount of calcium intake all influence the calcium-vitamin D metabolism [152,153,154,155] and bone mineral density, in some cases leading to osteoporosis, particularly in postmenopausal women [156].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [154]

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Authors
Holbrook, T., Barrett-Connor, E., & Wingard, D.
Affiliations
University of California San Diego (US)
ORCID
Barrett-Connor, Elizabeth
Venue
The Lancet
Publisher
Elsevier BV
Published
1988-11
Volume
332
Issue
8619
Pages
1046-1049
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(88)90065-7
OpenAlex
W2023387544
Cited by
385
References
24
Citations by year
2025: 2 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 11 · 2014: 2 · 2013: 8 · 2012: 6
FWCI
29.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01am031801-03)
  • U.S. Public Health Service (AC07181-01)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
dietary calcium, hip fracture, fracture risk, calcium intake, nutrient density, older adults, bone health
MeSH terms
Aged, Calcium, Dietary, California, Energy Intake, Female, Follow-Up Studies, Hip Fractures, Humans, Male, Middle Aged, Nutritional Status, Prospective Studies, Risk Factors, Sampling Studies

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