COMPARISON OF FLUCONAZOLE AND KETOCONAZOLE FOR OROPHARYNGEAL CANDIDIASIS IN AIDS
Abstract
In a randomised, double-blind study the efficacy and toxicity of oral fluconazole 50 mg daily and ketoconazole 200 mg daily were compared for the treatment of oropharyngeal candidiasis in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). 20 episodes (18 patients) were treated with fluconazole and 20 episodes (19 patients) with ketoconazole. Pretreatment clinical features and laboratory test results were similar in both groups. 17 episodes (85%) in the fluconazole group and 16 (80%) in the ketoconazole group could be evaluated. There was clinical cure at the end of therapy in all fluconazole-treated and 12 of 16 (75%) ketoconazole-treated episodes. Cultures were negative at the end of therapy in 87% of the fluconazole group and 69% of the ketoconazole group. 1 patients stopped taking fluconazole because of severe nausea. 1 of 18 fluconazole-treated and 4 of 19 ketoconazole-treated patients had transient rises in alanine or aspartate aminotransferase. Fluconazole seemed more effective than ketoconazole in the treatment of oral thrush among AIDS and ARC patients.
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Fluconazole is superior to ketoconazole for oropharyngeal candidiasis.
“Fluconazole is superior to ketoconazole [253].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [253]
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- Authors
- De Wit, S., Goossens, H., Weerts, D., & Clumeck, N.
- Affiliations
- Centre Hospitalier Universitaire de Saint-Pierre (BE)
- ORCID
- Goossens, H.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 333
- Issue
- 8641
- Pages
- 746-748
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1978615086
- Cited by
- 199
- References
- 20
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 21.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- fluconazole, ketoconazole, oropharyngeal candidiasis, AIDS, AIDS-related complex, oral candidiasis, antifungal efficacy, drug toxicity, nausea
- MeSH terms
- Acquired Immunodeficiency Syndrome, Administration, Oral, Adult, Aged, AIDS-Related Complex, Candidiasis, Oral, Clinical Trials as Topic, Double-Blind Method, Female, Follow-Up Studies, Humans, Ketoconazole, Male, Middle Aged, Oropharynx, Pharyngeal Diseases, Prospective Studies, Recurrence, Triazoles, Fluconazole
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