Azole antifungal agents: Emphasis on new triazoles

Saag, M S; Dismukes, W E

doi:10.1128/aac.32.1.1

Cited by 474Antifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control

Azole antifungal agents: Emphasis on new triazoles

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Saag, M S, Dismukes, W E·1988·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.32.1.1PMC PMC172087

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Abstract

Many advances have been made in antifungal therapy over the last three decades. Itraconazole and fluconazole, two investigational triazole agents, are the most recent additions to the list of antifungal drugs. This review has focused primarily on their mechanisms of action, favorable pharmacologic properties, and spectra of activity against a broad range of systemic pathogens. Itraconazole and fluconazole show much promise as orally active agents, with less potential for toxicity than the currently available azoles. Fluconazole and, to a lesser degree, itraconazole are especially promising therapies for cryptococcal meningitis. In addition, fluconazole may prove to be highly effective in urinary tract infections caused by Candida species and other fungi. Ongoing and future clinical trials will more clearly define the specific roles of itraconazole and fluconazole in the treatment of systemic mycoses.

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Authors: Saag, M. S., & Dismukes, W. E.
Affiliations: University of Alabama (US)
ORCID: Saag, M S
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 1988-01
Volume: 32
Issue: 1
Pages: 1-8
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.32.1.1
PMC: PMC172087
OpenAlex: W1971219620
Cited by: 474
References: 60
Citations by year: 2026: 5 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 6
FWCI: 53.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (N01 A1 52562)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: azole antifungals, triazoles, itraconazole, fluconazole, mechanism of action, cryptococcal meningitis, systemic fungal infection, oral antifungal agents, drug toxicity
MeSH terms: Animals, Antifungal Agents, Chemistry, Humans, Ketoconazole, Mycoses, Triazoles, Fluconazole, Itraconazole, Chemical Phenomena

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Azole antifungal agents: Emphasis on new triazoles

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