The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.
Abstract
Background Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.Methods We studied bronchoalveolar samples collected in 1989-99 from a prospective cohort of HIV-1-infected patients who had PCP. In 144 patients with 152 episodes of PCP, we analysed portions of DHPS using PCR and direct sequencing. The relation between survival, P. carinii DHPS mutations, and other predictors of treatment failure was assessed by Kaplan-Meier and multivariate Cox regression analysis.Findings P. carinii DHPS mutations were found in 31 (20.4%) of 152 PCP episodes. 3-month survival was significantly lower in patients infected with mutant P. carinii DHPS strains than in those with wild-type strains (p=0.002). After adjustment for other prognostic variables, presence of DHPS mutations remained the most important predictor of mortality (hazard ratio 3.1 [95% CI 1.2-8.1]). DHPS mutations were significantly more common in patients who had previous exposure to sulpha drugs (18 of 29 [62%]) than in those who had no exposure (13 of 123 [10.5%]; p<0.0001). A significant increase with time in the rate of DHPS mutations (p=0.01 for trend) was closely correlated with the rate of previous or current use of sulpha drugs as chemoprophylaxis.Interpretation Mutations in DHPS are associated with impaired prognosis in PCP, and may develop as a result of exposure to sulpha drugs.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Sulfa medications appear to exert selective pressure on Pneumocystis (18), as the DHPS gene is more likely to display mutations in highly conserved regions in patients with PCP who have previously been exposed to sulfa medications (19–25).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“Nevertheless, seven of the nine studies found that most HIV-infected patients with a diagnosis of PCP who had been prescribed TMP-SMX or dapsone for PCP prophylaxis had Pneumocystis that contained DHPS mutations (range 19%–80%, Table 2) (19–24,30).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“These DHPS gene mutations were rarely found in clinical isolates before the early 1990s (19,20,22).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“Several studies have consistently demonstrated a significant association between the use of TMP-SMX or dapsone for PCP prophylaxis in HIV-infected persons and the presence of DHPS gene mutations (Table 2) (19–25,30).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“In this study, DHPS mutation was the strongest predictor of death, and patients who had Pneumocystis that contained DHPS mutations had a greater than threefold increased risk for death within 3 months compared to patients with the wild-type DHPS, after important mortality cofactors such as age, CD4+/cell count, and arterial oxygen partial pressure (PaO2) were controlled for.”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“DHPS mutation was an independent predictor associated with increased deaths (OR = 3.1, p = 0.01).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“In fact, 12 (63%) of 19 PCP patients with Pneumocystis that contained DHPS gene mutations responded to PCP treatment with TMP-SMX.”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“In a multivariate analysis, Helweg-Larsen and colleagues found that DHPS mutations were an independent predictor associated with increased death rates (20).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“19 patients with DHPS mutations were treated with TMP-SMX: 7 died; 12 (63%) responded and survived.”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
Citations
Cites
Triglia, T., Menting, J. G. T., Wilson, C. M., & Cowman, A. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13944 · Cited by 421
Hardy, W. D., Feinberg, J., Finkelstein, D. M., Power, M. E., He, W., Kaczka, C., Frame, P. T., Holmes, M., Waskin, H. A., Fass, R. J., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272604 · Cited by 344
Montaner, J. S. G., Lawson, L. M., Levitt, N., Belzberg, A., Schechter, M. T., & Ruedy, J. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-1-14 · Cited by 242
Weverling, G. J., Mocroft, A., Ledergerber, B., Kirk, O., Gonzales-Lahoz, J., Monforte, A. D., Proenca, R., Phillips, A. N., Lundgren, J. D., & Reiss, P. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03287-0 · Cited by 220
Self-citationDihydropteroate synthase polymorphisms in Pneumocystis carinii.
Lane, B. R., Ast, J. C., Hossler, P. A., Mindell, D. P., Bartlett, M. S., Smith, J. W., & Meshnick, S. R. (1997) · Journal of Infectious Diseases · doi:10.1093/infdis/175.2.482 · Cited by 176
Kazanjian, P., Locke, A. B., Hossler, P. A., Lane, B. R., Bartlett, M. S., Smith, J. W., Cannon, M., & Meshnick, S. R. (1998) · AIDS · doi:10.1097/00002030-199808000-00009 · Cited by 171
Brenner, M., Ognibene, F. P., Lack, E. E., Simmons, J. T., Suffredini, A. F., Lane, H. C., Fauci, A. S., Parrillo, J. E., Shelhamer, J. H., & Masur, H. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1199 · Cited by 157
Mason, G. R., Hashimoto, C. H., Dickman, P. S., Foutty, L. F., & Cobb, C. J. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.6.1336 · Cited by 141
Clusters of Pneumocystis carinii pneumonia: analysis of person-to- person transmission by genotyping
Helweg‐Larsen, J. (1998) · QJM · doi:10.1093/qjmed/91.12.813 · Cited by 114
Self-citationDallas, W. S., Gowen, J. E., Ray, P. H., Cox, M. J., & Dev, I. K. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.18.5961-5970.1992 · Cited by 111
Cited by
Sorted by citations
Items 201–271 of 271
A Quantitative Model to Estimate Drug Resistance in Pathogens
Baker, F. N., Cushion, M. T., & Porollo, A. (2016) · Journal of Fungi · doi:10.3390/jof2040030 · Cited by 5
ZINNER, S. H., & Mayer, K. H. (2010) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-0-443-06839-3.00034-5 · Cited by 5
PROPHYLAXIS OF OPPORTUNISTIC INFECTIONS
Tantisiriwat, W., & Powderly, W. G. (2000) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70140-9 · Cited by 5
Pneumocystosis: Survey and DHPS Genotype Analysis in 14 Parisian Hospitals in 2003 and 2004
Magne, D., Lacube, P., Angoulvant, A., MELIANI, L., Botterel, F., Bougnoux, M., Chochillon, C., Cornet, M., Dannaoui, É., Datry, A., et al. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00191.x · Cited by 5
Polymorphisms involving the Pneumocystis jirovecii-related genes in AIDS patients in eastern China
Wang, M., Xu, X., Guo, Y., Tao, R., Hu, C., Dong, X., Huang, Y., & Zhu, B. (2019) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2019.103955 · Cited by 4
A Need for Standardized Definitions for Clinical Studies of Pneumocystis
Miller, R. F., & Huang, L. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00183.x · Cited by 4
Antifungal Drug Resistance in Developing Countries
Perlin, D. S. (2009) · Springer eBooks · doi:10.1007/978-0-387-89370-9_9 · Cited by 4
Masur, H. (2014) · ASM Press eBooks · doi:10.1128/9781555816971.ch12 · Cited by 4
Sinha, A., Rani, A., Mishra, V., Chaubey, S., & Mujeeb, F. (2024) · Springer eBooks · doi:10.1007/978-981-97-5272-0_30 · Cited by 3
Progress on nonculture based diagnostic tests for invasive mould infection
White, P. L. (2024) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000001060 · Cited by 3
Tsvetkova, N., Harizanov, R., Rainova, I., Ivanova, A., & Yancheva-Petrova, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316927 · Cited by 3
Costa, M. C., Gaspar, J., Ribeiro, C., Antunes, F., & Matos, O. (2003) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2003.tb00647.x · Cited by 3
Aliouat, E. M., Dei‐Cas, E., Gantois, N., Pottier, M., Pinçon, C., Hawser, S., Lier, A., & Huang, D. B. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3184-z · Cited by 3
Decker, C. F., & Masur, H. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6640-7_26 · Cited by 2
Drug Resistance in Pneumocystis jirovecii
Helweg‐Larsen, J., Benfield, T., Kovacs, J. A., & Masur, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-47266-9_22 · Cited by 2
Self-citationNdam, N. T., Dumont, B., Demanche, C., Chapel, A., Lacube, P., Guillot, J., & Roux, P. (2003) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2003.tb00674.x · Cited by 2
Cheung, C., & Shuter, J. (2010) · International Journal of STD & AIDS · doi:10.1258/ijsa.2009.009090 · Cited by 2
Manifestations respiratoires au cours de l'infection par le virus de l'immunodéficience humaine
Mayaud, C. M., Cadranel, J. L., & Naccache, J. (2001) · Encyclopédie médico-chirurgicale. Pneumologie · doi:10.1016/s1155-195x(01)00044-5 · Cited by 2
NOVEL DELIVERY APPROACHES OF CO-TRIMOXAZOLE FOR RECREATING ITS POTENTIAL USE-A REVIEW
Deshmukh, R., Harwansh, R. K., SHARMA, M., & Paul, S. D. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021v13i1.39623 · Cited by 2
Dihydropteroate Synthase (DHPS) Gene Mutations in Human Pneumocystosis
Mirdha, B. R. (2021) · Journal of AIDS and HIV Treatment · doi:10.33696/aids.3.015 · Cited by 2
Pneumocystis jirovecii Pneumonia in AIDS Patients
Jose, M., FRANCISCO, J. T., Dei‐Cas, E., & Enrique, J. (2011) · InTech eBooks · doi:10.5772/20082 · Cited by 2
Pneumocystis jiroveci Infection
Miller, R. F. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4470-3.50076-8 · Cited by 2
Pulmonary Manifestations of HIV Disease
Muhwa, J. C. (2011) · InTech eBooks · doi:10.5772/22700 · Cited by 1
Blot, F. (2003) · Réanimation · doi:10.1016/s1624-0693(03)00048-3 · Cited by 2
Pneumocystis jirovecii Pneumonia
Calderón, E. J., Varela, J. M., Durand-Joly, I., & Dei‐Cas, E. (2011) · Cited by 1
No Correlation Between ITS Genotypes and DHPS Mutations
Atzori, C., Fantoni, G., Valerio, A., Tronconi, E., Tartarone, F., Mazza, F., & Cargnel, A. (2004) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2004.tb00582.x · Cited by 1
General Pathology of HIV Infection
Finley, J. L., Joshi, V. V., & Smith, N. L. (2004) · Elsevier eBooks · doi:10.1016/b978-012764051-8/50029-9 · Cited by 1
Human Immunodeficiency Virus Infection
George, M. P., & Morris, A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1367-1.00141-5 · Cited by 1
Würbach, G., Schiller, F., Langguth, K., Godenschweger, K., & Braband, J. (1983) · PubMed · Cited by 1
HIV in the Intensive Care Unit
Rebollo, P. C., Nicolas, J. M., & Gatell, J. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-34406-3_6 · Cited by 1
Lung fibrosis in deceased HIV-infected patients with Pneumocystis pneumonia
Shaddock, E. J., Richards, G. A., & Murray, J. (2012) · Southern African Journal of HIV Medicine · doi:10.4102/sajhivmed.v13i2.140 · Cited by 1
Pneumocystis jirovecii genetic diversity in a Spanish tertiary hospital
Goterris, L., Pasic, L., Guerrero-Murillo, M., Kan, A., Antón, A., Ruíz-Camps, I., Meyer, W., & Martín-Gómez, M. T. (2021) · Medical Mycology · doi:10.1093/mmy/myab065 · Cited by 1
AIDS in the Intensive Care Unit
Forrest, D. M., Zala, C., Harris, M., Phillips, P., Russell, J. A., & Montaner, J. S. G. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1679-8_9 · Cited by 1
Approche moléculaire de la pneumocystose
Latouche, S., Santos, L. D., Lacube, P., BOLOGNINI, J., & Roux, P. (2000) · Revue Française des Laboratoires · doi:10.1016/s0338-9898(00)80398-4 · Cited by 1
Pneumocystis — A Genus Long Known, But with Relationships Only Recently Appreciated
Stringer, J. R., & Walzer, P. D. (2004) · Springer eBooks · doi:10.1007/978-3-662-10380-7_9 · Cited by 1
Cushion, M. T. (2010) · Wiley eBooks · doi:10.1002/9780470688618.taw0164 · Cited by 1
Robberts, F. J. L. (2005) · SUNScholar (Stellenbosch University) · Cited by 1
NEONATAL IMMUNE MODULATION TO IMPROVE PNEUMOCYSTIS CLEARANCE
Empey, K. M. (2007) · UKnowledge (University of Kentucky)
Pneumocystis cariniipneumonia (PCP)
Serchuck, L. K. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544798.045
Martínez, M. J. Á. (2008) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Mogoye, B. K., du Plessis, D., Poonsamy, B., & Frean, J. (2015) · Southern African Journal of Infectious Diseases · doi:10.1080/23120053.2015.1054180
Morio, F. (2014) · Journal des Anti-infectieux · doi:10.1016/j.antinf.2014.03.001
Transmission de Pneumocystis : quel risque environnemental et nosocomial ?
Choukri, F., & Derouin, F. (2011) · Journal des Anti-infectieux · doi:10.1016/j.antinf.2011.10.001
Human Immunodeficiency Virus,Pneumocystis carinii,Toxoplasma gondii, andLeishmaniaSpecies
Istúriz, R., & Gotuzzo, E. (2014) · ASM Press eBooks · doi:10.1128/9781555817947.ch20
Infecciones graves en pacientes inmunodeprimidos en oncohematología
Blot, F., Leclercq, B., & Nitenberg, G. (2001) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(01)71809-9
Management and Prevention of Opportunistic Infections in the HIV-Infected Patient
Purdy, B. D. (2000) · Journal of Pharmacy Practice · doi:10.1106/jdyc-jyvc-xjaa-lj1f
Fernandes, C. B. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Álvarez, M. J., Miró, J. M., Moreno, A., & Meshnick, S. (2005) · Medicina Clínica · doi:10.1157/13070426
Polyamines and Alveolar Macrophage Apoptosis during Pneumocystis Pneumonia
Liao, C.-P. (2009) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1937
11 Molecular Epidemiology of Pneumocystis Outbreaks
Hauser, P. M., & Kovacs, J. A. (2013) · Springer eBooks · doi:10.1007/978-3-642-39432-4_11
Neumocistosis. Abordaje terapéutico y profiláctico
Tsuji, Ó. V., & Rivera, T. C. (2004) · Acta Pediátrica de México
Drug Resistance in Pneumocystis jirovecii
Helweg‐Larsen, J., Benfield, T., Kovacs, J. A., & Masur, H. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-595-8_22
Self-citationHuang, L., Taylor, S. M., Worodria, W. O., Jarlsberg, L. G., Davis, J. L., Cattamanchi, A., Yoo, S., Andama, A. O., den Boon, S., Kyeyune, R. B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5212
Infectionsgraves chez l'immunodéprimé en oncohématologie
Blot, F., Nitenberg, G., & Leclercq, B. (2004) · EMC-Anesthésie réanimation/Encyclopédie médico-chirurgicale. Anesthésie, réanimation · doi:10.1016/s0246-0289(01)00037-8
Pulmonary Complications of HIV Infection
Wagner, K. R., & Chaisson, R. E. (2004) · Elsevier eBooks · doi:10.1016/b978-012764051-8/50018-4
Survival after Pneumocystis jirovecii pneumonia requiring ventilation: A case report
Nethathe, G. D., & Patel, N. C. (2016) · Southern African Journal of HIV Medicine · doi:10.4102/hivmed.v17i1.474
Kamezaki, H., Kanda, T., Yokosuka, O., Kasahara, Y., & Sakurai, T. (2017) · OBM Hepatology and Gastroenterology · doi:10.21926/obm.hg.1701001
Dhillon, B. K. (2016) · Summit (Simon Fraser University)
Pneumocystis Gene Mutations, Sulfa Resistance, and Decreased Survival
Wilson, M. (1999) · Journal watch · doi:10.1056/id199912010000002
Behandling och profylax av invasiva svampinfektioner - Bakgrundsdokumentation
Frøland, S. S. (2005)
[Research progress on genes mutations related to sulfa drug resistance in Pneumocystis jirovecii].
Wang, M., & Zhu, B. (2017) · PubMed Central · doi:10.3785/j.issn.1008-9292.2017.10.18
当院における免疫抑制治療中の潰瘍性大腸炎に合併したニューモシスチス肺炎に関する臨床的検討：case-control study
佐藤, 寿., 基, 内., 陽子, 横., 應田義雄, 樋田, 信., 憲治, 渡., 和敏, 堀., 洋人, 三., 浩基, 池., & 志郎, 中. (2018) · 日本外科感染症学会雑誌 · doi:10.24679/gekakansen.15.6_639
A Review on Nanoparticles of Co-Trimoxazole
Mishra, S. C. (2022) · INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT · doi:10.55041/ijsrem11642
Heller, R., Knobloch, J., Seitz, H. M., & Sitzmann, F. C. (2004) · Springer eBooks · doi:10.1007/978-3-642-18577-9_31
Bicanic, T. A., Logan, C., Gómez, B. L., Le, T. P., & Wasserman, S. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819990-9.00057-3
(2022) · Research and Applied Medicine · doi:10.55634/1.2.4
(2022) · Research and Applied Medicine · doi:10.55634/1.2.2
Xue, T., Fan, L., Du, W., Chen, X., Liu, C., Dai, W., Xu, J., Chen, L., & Ren, S. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1923465
Liu, J., Guo, Y., Yang, N., & Wang, L. (2026) · Research Square · doi:10.21203/rs.3.rs-10596459/v1
Ma, L., Hao, M., Chang, W., Khanal, A., Ewell, S. M., Deng, X., Sun, J., Azar, M. M., Cusini, A., Fehr, T. H., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adz4471
Self-citation
Metadata
- Authors
- Helweg-Larsen, J., Benfield, T. L., Eugen-Olsen, J., Lundgren, J. D., & Lundgren, B.
- Affiliations
- University of Copenhagen (DK)
- Statens Serum Institut (DK)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 354
- Issue
- 9187
- Pages
- 1347-1351
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2076316807
- Cited by
- 274
- References
- 30
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 10
- FWCI
- 18.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- Pneumocystis carinii pneumonia, dihydropteroate synthase, dhps mutations, HIV-1 infection, AIDS, survival, mortality, chemoprophylaxis, folate biosynthesis, treatment failure
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Dihydropteroate Synthase, Drug Resistance, Microbial, Genotype, Humans, Middle Aged, Pneumocystis, Pneumonia, Pneumocystis, Prognosis, Recurrence, Regression Analysis, Sulfamethoxazole, Cohort Studies, HIV-1, Survival Analysis, Polymerase Chain Reaction, AIDS-Related Opportunistic Infections, Point Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
