Cited by 274Pneumocystis jirovecii pneumonia detection and treatmentPneumonia and Respiratory InfectionsHIV/AIDS drug development and treatment

The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.

Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.

Helweg-Larsen, Jannik, Benfield, Thomas L, Eugen-Olsen, Jesper, Lundgren, Jens D, Lundgren, Bettina·1999·The Lancet

DOI 10.1016/s0140-6736(99)03320-6

Open this paper in CoChat — free account

Abstract

Background Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.Methods We studied bronchoalveolar samples collected in 1989-99 from a prospective cohort of HIV-1-infected patients who had PCP. In 144 patients with 152 episodes of PCP, we analysed portions of DHPS using PCR and direct sequencing. The relation between survival, P. carinii DHPS mutations, and other predictors of treatment failure was assessed by Kaplan-Meier and multivariate Cox regression analysis.Findings P. carinii DHPS mutations were found in 31 (20.4%) of 152 PCP episodes. 3-month survival was significantly lower in patients infected with mutant P. carinii DHPS strains than in those with wild-type strains (p=0.002). After adjustment for other prognostic variables, presence of DHPS mutations remained the most important predictor of mortality (hazard ratio 3.1 [95% CI 1.2-8.1]). DHPS mutations were significantly more common in patients who had previous exposure to sulpha drugs (18 of 29 [62%]) than in those who had no exposure (13 of 123 [10.5%]; p<0.0001). A significant increase with time in the rate of DHPS mutations (p=0.01 for trend) was closely correlated with the rate of previous or current use of sulpha drugs as chemoprophylaxis.Interpretation Mutations in DHPS are associated with impaired prognosis in PCP, and may develop as a result of exposure to sulpha drugs.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(99)03320-6

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum
Triglia, T., Menting, J. G. T., Wilson, C. M., & Cowman, A. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13944 · Cited by 421
A Controlled Trial of Trimethoprim–Sulfamethoxazole or Aerosolized Pentamidine for Secondary Prophylaxis ofPneumocystis cariniiPneumonia in Patients with the Acquired Immunodeficiency Syndrome
Hardy, W. D., Feinberg, J., Finkelstein, D. M., Power, M. E., He, W., Kaczka, C., Frame, P. T., Holmes, M., Waskin, H. A., Fass, R. J., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272604 · Cited by 344
Corticosteroids Prevent Early Deterioration in Patients with Moderately Severe Pneumocystis carinii Pneumonia and the Acquired Immunodeficiency Syndrome (AIDS)
Montaner, J. S. G., Lawson, L. M., Levitt, N., Belzberg, A., Schechter, M. T., & Ruedy, J. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-1-14 · Cited by 242
Discontinuation of Pneumocystis carinii pneumonia prophylaxis after start of highly active antiretroviral therapy in HIV-1 infection
Weverling, G. J., Mocroft, A., Ledergerber, B., Kirk, O., Gonzales-Lahoz, J., Monforte, A. D., Proenca, R., Phillips, A. N., Lundgren, J. D., & Reiss, P. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03287-0 · Cited by 220
Self-citation
Dihydropteroate synthase polymorphisms in Pneumocystis carinii.
Lane, B. R., Ast, J. C., Hossler, P. A., Mindell, D. P., Bartlett, M. S., Smith, J. W., & Meshnick, S. R. (1997) · Journal of Infectious Diseases · doi:10.1093/infdis/175.2.482 · Cited by 176
Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients.
Kazanjian, P., Locke, A. B., Hossler, P. A., Lane, B. R., Bartlett, M. S., Smith, J. W., Cannon, M., & Meshnick, S. R. (1998) · AIDS · doi:10.1097/00002030-199808000-00009 · Cited by 171
Prognostic Factors and Life Expectancy of Patients with Acquired Immunodeficiency Syndrome and Pneumocystis carinii Pneumonia
Brenner, M., Ognibene, F. P., Lack, E. E., Simmons, J. T., Suffredini, A. F., Lane, H. C., Fauci, A. S., Parrillo, J. E., Shelhamer, J. H., & Masur, H. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1199 · Cited by 157
Prognostic Implications of Bronchoalveolar Lavage Neutrophilia in Patients with Pneumocystis carinii Pneumonia and AIDS
Mason, G. R., Hashimoto, C. H., Dickman, P. S., Foutty, L. F., & Cobb, C. J. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.6.1336 · Cited by 141
Clusters of Pneumocystis carinii pneumonia: analysis of person-to- person transmission by genotyping
Helweg‐Larsen, J. (1998) · QJM · doi:10.1093/qjmed/91.12.813 · Cited by 114
Self-citation
Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100.
Dallas, W. S., Gowen, J. E., Ray, P. H., Cox, M. J., & Dev, I. K. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.18.5961-5970.1992 · Cited by 111

Show all 30 references

Sorted by citations

Items 101–200 of 271

Management of Patients with HIV in the Intensive Care Unit
Masur, H. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200511-122jh · Cited by 32
Expression and Characterization of Recombinant Human-Derived Pneumocystis carinii Dihydrofolate Reductase
Ma, L., & Kovacs, J. A. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3092-3096.2000 · Cited by 31
Pneumocystis Pneumonia
Barry, S. M., & Johnson, M. A. (2004) · Clinical Pulmonary Medicine · doi:10.1097/01.cpm.0000127197.91607.a0 · Cited by 30
A Model to Predict In-Hospital Mortality in HIV/AIDS Patients with Pneumocystis Pneumonia in China: The Clinical Practice in Real World
Wu, L. S., Zhang, Z., Wang, Y., Hao, Y., Wang, F., Gao, G., Yang, D., Jiang, X., & Zhao, H. (2019) · BioMed Research International · doi:10.1155/2019/6057028 · Cited by 30
Prospective cohort study showing changes in the monthly incidence of Pneumocystis carinii pneumonia
Lubis, N., Baylis, D., Short, A., Stebbing, J., Teague, A., Portsmouth, S., Bower, M., Nelson, M. R., & Gazzard, B. (2003) · Postgraduate Medical Journal · doi:10.1136/pmj.79.929.164 · Cited by 30
Performance of a molecular viability assay for the diagnosis of Pneumocystis pneumonia in HIV-infected patients
de Oliveira, A., Unnasch, T. R., Crothers, K. A., Eiser, S., Zucchi, P., Moir, J., Beard, C. B., Lawrence, G. G., & Huang, L. (2006) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2006.08.015 · Cited by 30
Multilocus Microsatellite Genotyping Array for Investigation of Genetic Epidemiology of Pneumocystis jirovecii
Parobek, C. M., Jiang, L. Y., Patel, J. C., Álvarez-Martínez, M. J., Miró, J. M., Worodria, W. O., Andama, A. O., Fong, S., Huang, L., Meshnick, S. R., et al. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02531-13 · Cited by 29
Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia
Costa, M. C., Helweg‐Larsen, J., Lundgren, B., Antunes, F., & Matos, O. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00122-5 · Cited by 29
Self-citation
Pneumocystis jirovecii multilocus genotyping in pooled DNA samples: a new approach for clinical and epidemiological studies
Esteves, F., Gaspar, J., de Sousa, B. C., Antunes, F., Mansinho, K., & Matos, O. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03828.x · Cited by 28
Pulmonary infections in the HIV-infected patient in the era of highly active antiretroviral therapy: An update
Lazarous, D. G., & O’Donnell, A. E. (2007) · Current Infectious Disease Reports · doi:10.1007/s11908-007-0036-x · Cited by 28
Life-Threatening Complications of HIV Infection
Davaro, R. E., & Thirumalai, A. (2007) · Journal of Intensive Care Medicine · doi:10.1177/0885066606297964 · Cited by 28
Dihydropteroate Synthase and Novel Dihydrofolate Reductase Gene Mutations in Strains of Pneumocystis jirovecii from South Africa
Robberts, F. J. L., Chalkley, L. J., Weyer, K., Goussard, P., & Liebowitz, L. D. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.3.1443-1444.2005 · Cited by 28
Prevalence of Dihydropteroate Synthase Mutants in HIV‐Infected South African Children withPneumocystis jiroveciPneumonia
Zar, H. J., Álvarez-Martínez, M. J., Harrison, A. L., & Meshnick, S. (2004) · Clinical Infectious Diseases · doi:10.1086/424010 · Cited by 28
Pneumocystis jiroveci in Portuguese immunocompromised patients: association of specific ITS genotypes with treatment failure, bad clinical outcome and childhood
Matos, O., Lee, C., Jin, S., Li, B., Costa, M. C., Gonçalves, L. A. P., & Antunes, F. (2003) · Infection Genetics and Evolution · doi:10.1016/s1567-1348(03)00092-3 · Cited by 27
Prophylaxis Failure Is Associated with a SpecificPneumocystis cariniiGenotype
Hauser, P. M., Sudre, P., Nahimana, A., Francioli, P. B., & the Study Group (2001) · Clinical Infectious Diseases · doi:10.1086/322659 · Cited by 27
Clinical applications of non-culture based methods for the diagnosis and management of opportunistic and endemic mycoses
Verweij, P. E., Figueroa, J., van Burik, J., Holdom, M. D., Dei‐Cas, E., Gómez, B. L., & Mendes‐Giannini, M. J. S. (2000) · Medical Mycology · doi:10.1080/mmy.38.s1.161.171 · Cited by 27
Pneumocystis jirovecii colonization in Chronic Obstructive Pulmonary Disease (COPD)
Khodavaisy, S., Mortaz, E., Mohammadi, F., Aliyali, M., Fakhim, H., & Badali, H. (2015) · Current Medical Mycology · doi:10.18869/acadpub.cmm.1.1.42 · Cited by 26
Dihydropteroate synthase mutations inPneumocystispneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort
Yoon, C., Subramanian, A., Chi, A., Crothers, K. A., Meshnick, S. R., Taylor, S. M., Beard, C. B., Jarlsberg, L. G., Lawrence, G. G., Avery, M., et al. (2013) · Medical Mycology · doi:10.3109/13693786.2013.770604 · Cited by 25
Neuropsychological characteristics of adolescent boys differing in risk for high blood pressure
Ditto, B., Séguin, J. R., & Tremblay, R. E. (2006) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm3103_4 · Cited by 25
Study of DHPS and DHFR genes ofPneumocystis jiroveciiin Thai HIV-infected patients
Siripattanapipong, S., Leelayoova, S., Mungthin, M., Worapong, J., & Tan‐ariya, P. (2008) · Medical Mycology · doi:10.1080/13693780701883722 · Cited by 24
El ser humano como reservorio de Pneumocystis
Wissmann, G., Morilla, R., Friaza, V., Calderón, E. J., & VARELA, J. M. (2009) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2008.07.008 · Cited by 24
Detection of Pneumocystis jirovecii dihydropteroate synthase polymorphisms in patients with Pneumocystis pneumonia
Costa, M. C., Gaspar, J., Mansinho, K., Esteves, F., Antunes, F., & Matos, O. (2005) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540510038505 · Cited by 24
Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV infection: An observational cohort study
Fei, M. W., Sant, C. A., Kim, E. J., Swartzman, A., Davis, J. L., Jarlsberg, L. G., & Huang, L. (2009) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540903051633 · Cited by 24
Diagnosis and Management of Pneumocystis Pneumonia in Resource-poor Settings
Oladele, R. O., Otu, A. A., Richardson, M. D., & Denning, D. W. (2018) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2018.0010 · Cited by 23
Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1–infected patients
Álvarez-Martínez, M. J., Miró, J. M., Valls, M. E., Mas, J., de la Bellacasa, J. P., Sued, O. G., Solé, M., Rivas, P. V., de Lazzari, E., Benito, N., et al. (2010) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2010.04.007 · Cited by 23
Human immunodeficiency virus and respiratory infection
Ashley, E. A., Johnson, M. A., & Lipman, M. C. I. (2000) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200005000-00013 · Cited by 23
A prognostic scoring tool for identification of patients at high and low risk of death from HIV-associated Pneumocystis jirovecii pneumonia
Armstrong-James, D. P. H., Copas, A. J., Walzer, P. D., Edwards, S., & Miller, R. F. (2011) · International Journal of STD & AIDS · doi:10.1258/ijsa.2011.011040 · Cited by 22
Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia
Esteves, F., de Sousa, B. C., Calderón, E. J., Huang, L., Badura, R. A., Maltêz, F., Bassat, Q., de Armas, Y., Antunes, F., & Matos, O. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.03.013 · Cited by 22
Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort
Suárez, I., Roderus, L., van Gumpel, E., Jung, N., Lehmann, C., Fätkenheuer, G., Hartmann, P., Plum, G., & Rybniker, J. (2017) · Infection · doi:10.1007/s15010-017-1005-4 · Cited by 22
OPPORTUNISTIC INFECTIONS IN HIV DISEASE: DOWN BUT NOT OUT
Sax, P. E. (2001) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70155-0 · Cited by 22
Independent risk of mechanical ventilation for AIDS-related Pneumocystis carinii pneumonia associated with bronchoalveolar lavage neutrophilia
Bang, D., EMBORG, J., Elkjær, J. M., Lundgren, J. D., & Benfield, T. (2001) · Respiratory Medicine · doi:10.1053/rmed.2001.1119 · Cited by 22
Self-citation
Linking Pneumocystis jiroveci sulfamethoxazole resistance to the alleles of the DHPS gene using functional complementation in Saccharomyces cerevisiae
Moukhlis, R., Boyer, J., Lacube, P., BOLOGNINI, J., Roux, P., & Hennequin, C. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02833.x · Cited by 22
Detection of Pneumocystis carinii and Characterization of Mutations Associated with Sulfa Resistance in Bronchoalveolar Lavage Samples from Human Immunodeficiency Virus-Infected Subjects
Zingale, A., Carrera, P., Lazzarin, A., & Scarpellini, P. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.6.2709-2712.2003 · Cited by 22
Rapid Detection of Mutations in the Human-Derived Pneumocystis carinii Dihydropteroate Synthase Gene Associated with Sulfa Resistance
Ma, L., & Kovacs, J. A. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.3.776-780.2001 · Cited by 22
Pneumocystisjirovecii dihydropteroate synthase genotypes in French patients with pneumocystosis: a 1998–2001 prospective study
Latouche, S., Lacube, P., Maury, E., Bolognini, J., Develoux, M., Girard, P., Godet, C., Lebrette, M., Mayaud, C., Guillot, J., et al. (2003) · Medical Mycology · doi:10.1080/13693780310001615394 · Cited by 19
Genotypic variation of Pneumocystis jirovecii isolates in India based on sequence diversity at mitochondrial large subunit rRNA
Gupta, R., Mirdha, B. R., Guleria, R., Agarwal, S. K., Samantaray, J. C., Kumar, L., Kabra, S. K., Luthra, K., Sreenivas, V., & Iyer, V. K. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.05.001 · Cited by 19
Pneumocystis jiroveciipneumonia in Latin America. A public health problem?
Calderón, E. J., de Armas, Y., Panizo, M. M., & Wissmann, G. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.13.41 · Cited by 19
Circulation of Pneumocystis dihydropteroate synthase mutants in France
Gal, S. L., Damiani, C., Perrot, M., Rouillé, A., Virmaux, M., Quinio, D., Moalic, E., Saliou, P., Berthou, C., Meur, Y. L., et al. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.06.002 · Cited by 19
Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii
de la Horra, C., Friaza, V., Morilla, R., Delgado, J., Medrano, F. J., Miller, R. F., de Armas, Y., & Calderón, E. J. (2021) · Journal of Fungi · doi:10.3390/jof7100856 · Cited by 18
AIDS and the lung in a changing world
Mayaud, C. M., & CADRANEL, J. (2001) · Thorax · doi:10.1136/thorax.56.6.423 · Cited by 18
Dendritic cell ontogeny as an aetiological factor in respiratory tract diseases in early life
Holt, P. G. (2001) · Thorax · doi:10.1136/thorax.56.6.419 · Cited by 18
Pneumocystis jiroveciDihydropteroate Synthase Gene Mutations among Colonized Individuals andPneumocystisPneumonia Patients from Spain
Friaza, V., Morilla, R., RESPALDIZA, N., de la Horra, C., & Calderón, E. J. (2010) · Postgraduate Medicine · doi:10.3810/pgm.2010.11.2219 · Cited by 17
Analysis of Pneumocystis jirovecii DHPS Alleles Implicated in Sulfamethoxazole Resistance Using an Escherichia coli Model System
Iliades, P., Meshnick, S. R., & Macreadie, I. G. (2005) · Microbial Drug Resistance · doi:10.1089/mdr.2005.11.1 · Cited by 17
DiscontinuingPneumocystis cariniiProphylaxis
Girard, P. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101183440310 · Cited by 17
A Case of Pneumonia Caused by Pneumocystis jirovecii Resistant to Trimethoprim-Sulfamethoxazole
Lee, S. M., Cho, Y. K., Sung, Y. M., Chung, D. H., Jeong, S. H., Park, J.-W., & Lee, S. P. (2015) · Korean Journal of Parasitology · doi:10.3347/kjp.2015.53.3.321 · Cited by 16
Molecular diagnosis and detection of Pneumocystis jirovecii DHPS and DHFR genotypes in respiratory specimens from Colombian patients
Muñoz, C. O., Zuluaga, A., Restrepo, Á., Tobón, Á. M., Cano, L. E., & González, Á. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2011.11.015 · Cited by 16
Prevalence and genotyping of Pneumocystis jirovecii in renal transplant recipients—preliminary report
Szydłowicz, M., Jakuszko, K. J., Szymczak, A., Piesiak, P., Kowal, A., Kopacz, Ż., Wesołowska, M., Lobo, M., Matos, O., Hendrich, A. B., et al. (2018) · Parasitology Research · doi:10.1007/s00436-018-6131-0 · Cited by 15
Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations and Human Immunodeficiency Virus‐Associated Pneumocystis Pneumonia
Huang, L., Welsh, D. A., Miller, R. F., Beard, C. B., Lawrence, G. G., Fox, M., Swartzman, A., Bensley, M. R., CARBONNET, D., Davis, J. L., et al. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00195.x · Cited by 14
Sepsis predisposition in children with human immunodeficiency virus
Hatherill, M. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000161579.39050.6b · Cited by 14
Pneumocystis carinii pneumonia in patients with connective tissue diseases
Saito, K., & Tanaka, Y. (2002) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.25.310 · Cited by 14
Absence of mutations associated with sulfa resistance in Pneumocystis carinii dihydropteroate synthase gene from non-human primates.
Demanche, C., Guillot, J., Berthelemy, M., Petit, T., Roux, P., & Wakefield, A. E. (2002) · Medical Mycology · doi:10.1080/714031111 · Cited by 13
Risk of Pneumocystis jirovecii Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study
Cheng, Y., Huang, C.-H., Gau, S., Chung, N.-J., Huang, S.-W., Huang, C.-Y., & Lee, C. (2022) · Journal of Fungi · doi:10.3390/jof9010023 · Cited by 13
Characterization of the Meiosis‐Specific Recombinase Dmc1 ofPneumocystis
Kutty, G., Achaz, G., Maldarelli, F. M., Varma, A., Shroff, R., Becker, S., Fantoni, G., & Kovacs, J. A. (2010) · The Journal of Infectious Diseases · doi:10.1086/657414 · Cited by 13
Study of dihydropteroate synthase (DHPS) gene mutations among isolates of Pneumocystis jiroveci.
Tyagi, A. K., Mirdha, B. R., Guleria, R., Mohan, A., Luthra, K., & Singh, U. B. (2008) · PubMed · Cited by 13
Dihydropteroate synthase gene mutation rates in Pneumocystis jirovecii strains obtained from Iranian HIV-positive and non-HIV-positive patients
Sheikholeslami, F. M., Sadraei, J., Farnia, P., Moghadam, M. F., & Emadi-Kochak, H. (2015) · Medical Mycology · doi:10.1093/mmy/myu095 · Cited by 13
Long-term safety of discontinuation of secondary prophylaxis against Pneumocystis pneumonia
Zellweger, C., Opravil, M., Bernasconi, E., Cavassini, M. L., Bucher, H. C., Schiffer, V., Wagels, T., Flepp, M., Rickenbach, M., & Furrer, H. (2004) · AIDS · doi:10.1097/00002030-200410210-00009 · Cited by 13
Pneumocystis Dihydropteroate Synthase Mutations in Patients with Pneumocystis Pneumonia Who Are Newly Diagnosed with HIV Infection
CROTHERS, K., HUANG, L., MORRIS, A., FOX, M., GRONER, G., TURNER, J. R., MERRIFIELD, C., EISER, S., FRIEDLY, J., GRAVARI, E., et al. (2003) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2003.tb00648.x · Cited by 12
Clinical Characteristics and Risk Factors for Pneumocystis Jirovecii Pneumonia during Immunosuppressive Treatment in Patients with Ulcerative Colitis: A Retrospective Study
Kojima, K., Sato, T., Uchino, M., Yokoyama, Y., Takagawa, T., Ohda, Y., Hida, N., Watanabe, K., Hori, K., Miwa, H., et al. (2020) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-854 · Cited by 12
Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii
Pasic, L., Goterris, L., Guerrero-Murillo, M., Irinyi, L., Kan, A., Ponce, C. A., Vargas, S. L., Martín-Gómez, M. T., & Meyer, W. (2020) · Journal of Fungi · doi:10.3390/jof6040259 · Cited by 12
A novel droplet digital polymerase chain reaction for diagnosis of Pneumocystis pneumonia (PCP)-a clinical performance study and survey of sulfamethoxazole-trimethoprim resistant mutations
Jitmuang, A., Nititammaluk, A., Boonsong, T., Sarasombath, P. T., Sompradeekul, S., & Chayakulkeeree, M. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.09.014 · Cited by 12
Clinical and translational research inPneumocystisandPneumocystis pneumonia
Huang, L. (2011) · Parasite · doi:10.1051/parasite/2011181003 · Cited by 12
Sulfonamides and Trimethoprim
Sköld, O., & Swedberg, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-46718-4_24 · Cited by 14
Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli
Iliades, P., Walker, D. J., Castelli, L. A., Satchell, J. F., Meshnick, S. R., & Macreadie, I. G. (2004) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2004.08.006 · Cited by 12
Early recurrence of Pneumocystis jiroveci pneumonia in two HIV‐infected patients: Linking infection relapse and immune reconstitution syndrome
Kolditz, M., Halank, M., Bandt, D., Spornraft‐Ragaller, P., & Höffken, G. (2009) · Respirology · doi:10.1111/j.1440-1843.2009.01583.x · Cited by 12
Pneumocystose chez les patients d’onco-hématologie : est-ce inévitable ?
Castro, N. D., Pavie, J., Lagrange-Xélot, M., & Molina, J. (2007) · Revue des Maladies Respiratoires · doi:10.1016/s0761-8425(07)91148-1 · Cited by 11
Pneumocystis jirovecii dihydropteroate synthase gene mutations in a group of HIV-negative immunocompromised patients with Pneumocystis pneumonia
Long, Y., Zhang, C., Su, L., & Que, C. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.2002 · Cited by 11
PCR‐RFLP Analysis of the DHPS gene for the Study of Resistance of Pneumocystis carinii to Sulpha Drugs in Patients with Co‐infection PCP/HIV
Costa, M. C., Helweg‐Larsen, J., Antunes, F., LUNGREN, B., Diogo, J., & Matos, O. (2001) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2001.tb00493.x · Cited by 11
Self-citation
Pneumocystis carinii.Dihydropteroate Synthase Mutations and Treatment with Sulfa or Sulfone Regimens: a Proposal for Standardized Definitions for Clinical Evaluation
HUANG, L., MORRIS, A. M., & BEARD, C. B. (2001) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2001.tb00510.x · Cited by 10
Absence of dihydropteroate synthase gene mutations inPneumocystis jiroveciiisolated from Swedish patients
Beser, J., Dini, L., Botero-Kleiven, S., Krabbe, M., Lindh, J. G., & Hagblom, P. (2012) · Medical Mycology · doi:10.3109/13693786.2011.593051 · Cited by 10
Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia
Tyagi, A. K., Mirdha, B. R., Luthra, K., Guleria, R., Mohan, A., Singh, U. B., Samantaray, J. C., Dar, L., Iyer, V. K., & Chaudhry, R. (2010) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.914 · Cited by 10
Pneumocystis carinii pneumonia in patients with and without HIV infection
Santamauro, J. T., Aurora, R. N., & Stover, D. E. (2002) · Comprehensive Therapy · doi:10.1007/s12019-002-0047-3 · Cited by 10
Pneumocystis carinii Dihydropteroate Synthase Genotypes in HIV‐infected Persons Residing in San Francisco: Possible Implications for Disease Transmission
HUANG, L., FRIEDLY, J., MORRIS, A. M., CARTER, J. L., TURNER, J. R., MERRIFIELD, C., NAVIN, T. R., & BEARD, C. B. (2001) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2001.tb00487.x · Cited by 9
The presence of Pneumocystis jirovecii DNA in plasma is associated with a higher mortality rate in patients with AIDS-associated Pneumocystis pneumonia
Wang, M., Dai, X., Huang, Y., Sun, J., Dong, X., Guo, Y., Hu, C., Zhou, Q., & Zhu, B. (2018) · Medical Mycology · doi:10.1093/mmy/myy110 · Cited by 9
Molecular detection of Pneumocystis jirovecii in patients with respiratory tract infections
Alli, O. A. T., Ogbolu, D. O., Ademola, O., & Oyenike, M. A. (2012) · North American Journal of Medical Sciences · doi:10.4103/1947-2714.101993 · Cited by 9
Pneumocystis
Pfaller, M. A., & Anaissie, E. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00017-7 · Cited by 9
Distribution of DHPS Mutations Among ITS Subtypes of P. carinii f. sp. hominis
Meshnick, S. R., Hossler, P. A., Enger, K. S., Kazanjian, P. H., Rest, J. S., Mindell, D. P., Li, B., Lee, C., Nimri, L. F., Carter, J. L., et al. (2001) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2001.tb00481.x · Cited by 9
Molecular Characterization of Recombinant Pneumocystis carinii Topoisomerase I: Differential Interactions with Human Topoisomerase I Poisons and Pentamidine
Dross, R. V., & Sanders, M. M. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.7.2145-2154.2002 · Cited by 9
Typing ofPneumocystis jiroveciiisolates from Iranian immunosuppressed patients based on the Internal Transcribed Spacer (ITS) region of the rRNA gene
Sheikholeslami, F. M., Sadraei, J., Farnia, P., Moghadam, M. F., & Kochak, H. E. (2013) · Medical Mycology · doi:10.3109/13693786.2013.811553 · Cited by 8
Seasonal variation in mortality of Pneumocystis jirovecii pneumonia in HIV-infected patients
Miller, R. F., Evans, H. E. R., Copas, A. J., Huggett, J. F., Edwards, S., & Walzer, P. D. (2010) · International Journal of STD & AIDS · doi:10.1258/ijsa.2010.010148 · Cited by 8
Inability of Pneumocystis organisms to incorporate bromodeoxyuridine suggests the absence of a salvage pathway for thymidine
Vestereng, V. H., & Kovacs, J. A. (2004) · Microbiology · doi:10.1099/mic.0.26890-0 · Cited by 8
Laboratory diagnosis of Pneumocystis jirovecii pneumonia
Matos, O., & Esteves, F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804543-5.00013-0 · Cited by 8
Pneumocystis jirovecii and Pneumocystosis
Matos, O., Tomás, A. L., & Antunes, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-64113-3_7 · Cited by 8
Sulfonamides and Trimethoprim
Sköld, O. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-180-2_23 · Cited by 8
Pneumocystis Carinii Pneumonia in Adult Non-HIV Disorders
Gilmartin, G. S., & Koziel, H. (2002) · Journal of Intensive Care Medicine · doi:10.1177/0885066602238031 · Cited by 8
Functional Complementation of the Yeast P‐type H+‐ATPase, PMA1, by the Pneumocystis carinii P‐type H+‐ATPase, PCA1
Grigore, D., & Meade, J. C. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00089.x · Cited by 8
Resistencia genotípica a sulfamidas en pacientes con neumonía por Pneumocystis jiroveci
Calderón, E. J., de la Horra, C., Montes‐Cano, M. A., RESPALDIZA, N., Martín‐Juan, J., & Varela, J. M. (2004) · Medicina Clínica · doi:10.1016/s0025-7753(04)74328-6 · Cited by 8
Intensive Care of Patients With HIV Infection
Morris, A. M., & Huang, L. (2004) · CHEST Journal · doi:10.1378/chest.125.5.1602 · Cited by 8
Prophylaxis of Pneumocystis carinii pneumonia: too much of a good thing?
Miller, R. F. (2000) · Thorax · doi:10.1136/thorax.55.suppl_1.s15 · Cited by 8
Circulating genotypes of Pneumocystis jirovecii and its clinical correlation in patients from a single tertiary center in India
Singh, Y., Mirdha, B. R., Guleria, R., Khalil, S. S., Panda, A., Chaudhry, R., Mohan, A., Kabra, S. K., Kumar, L., & Agarwal, S. K. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-2977-9 · Cited by 7
Pneumocystis jirovecii Carriage in Portuguese Immunocompetent Patients: Preliminary Results
Matos, O., Costa, M. C., Correia, I., MONTEIRO, P., Monteiro, M., Soares, J., Vieira, J. R., Bonnet, M., & Antunes, F. (2003) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2003.tb00668.x · Cited by 7
Molecular epidemiology of Pneumocystis jiroveci in human immunodeficiency virus-positive and -negative immunocompromised patients in The Netherlands
Vanspauwen, M. J., Knops, V. E. J., Bruggeman, C. A., van Mook, W., & Linssen, C. F. M. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.076257-0 · Cited by 6
Molecular Study of Pneumocystis jirovecii in Respiratory Samples of HIV Patients in Chile
Iturrieta‐González, I., Chahín, C., Cabrera, J., Concha, C., Olivares-Ferretti, P., Briones, J., Vega, F., Medina, L., & Fonseca-Salamanca, F. (2024) · Journal of Fungi · doi:10.3390/jof10020117 · Cited by 6
Pneumocystis jiroveciidihydropteroate synthase (DHPS) genotypes in non-HIV-immunocompromised patients: a tertiary care reference health centre study
Tyagi, A. K., Mirdha, B. R., Luthra, K., Guleria, R., Mohan, A., Singh, U. B., Samantaray, J. C., Dar, L., Iyer, V. K., & Sreenivas, V. (2010) · Medical Mycology · doi:10.3109/13693786.2010.505584 · Cited by 6
Prevalence of DHPS Polymorphisms Associated with Sulfa Resistance in South African Pneumocystis jirovecii Strains
Dini, L., du Plessis, M., Wong, M., Karstaedt, A., Fernandez, V., & Frean, J. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00193.x · Cited by 6
Pneumonie à Pneumocystis jirovecii chez les patients infectés par le VIH
Castro, N. D., Scemla, A., Gallien, S., & Molina, J. (2012) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2011.10.975 · Cited by 6
Geographical Variation in the Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Mutations Within Western Europe
Rabodonirina, M., Nahimana, A., Weber, R. K., Francioli, P. B., Billé, J., & Hauser, P. M. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00194.x · Cited by 6
Severe Pneumocystis pneumonia in a renal transplant recipient after long term mycophenolate mofetil treatment
Totet, A., Westeel, P. F., & Nevez, G. (2005) · Revista do Instituto de Medicina Tropical de São Paulo · doi:10.1590/s0036-46652005000500012 · Cited by 6
Factores pronósticos de mortalidad durante el episodio de neumonía por Pneumocystis carinii en pacientes con infección por VIH
Fernández‐Cruz, A., Pulido, F., de Rivera, J. M. P. S., García, M. S., Hernández, A. L., González‐García, J., & García, R. R. (2002) · Revista Clínica Española · doi:10.1016/s0014-2565(02)71100-4 · Cited by 6
Pneumocystis Pneumonia
Masur, H., & Shelhamer, J. H. (2000) · CHEST Journal · doi:10.1378/chest.118.3.575 · Cited by 5
Mycoses bronchopulmonaires (aspects immunoallergiques exclus)
Germaud, P., Boutoille, D., & Gay‐Andrieu, F. (2010) · Encyclopédie médico-chirurgicale. Pneumologie · doi:10.1016/s1155-195x(10)19078-1 · Cited by 5

Authors: Helweg-Larsen, J., Benfield, T. L., Eugen-Olsen, J., Lundgren, J. D., & Lundgren, B.
Affiliations: University of Copenhagen (DK)
Statens Serum Institut (DK)
ORCID: Benfield, Thomas L
Lundgren, Jens D
Venue: The Lancet
Publisher: Elsevier BV
Published: 1999-10
Volume: 354
Issue: 9187
Pages: 1347-1351
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(99)03320-6
OpenAlex: W2076316807
Cited by: 274
References: 30
Citations by year: 2026: 3 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 10
FWCI: 18.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Sundhed og Sygdom, Det Frie Forskningsråd
Topics: Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: Pneumocystis carinii pneumonia, dihydropteroate synthase, dhps mutations, HIV-1 infection, AIDS, survival, mortality, chemoprophylaxis, folate biosynthesis, treatment failure
MeSH terms: Adult, Aged, Bronchoalveolar Lavage Fluid, Dihydropteroate Synthase, Drug Resistance, Microbial, Genotype, Humans, Middle Aged, Pneumocystis, Pneumonia, Pneumocystis, Prognosis, Recurrence, Regression Analysis, Sulfamethoxazole, Cohort Studies, HIV-1, Survival Analysis, Polymerase Chain Reaction, AIDS-Related Opportunistic Infections, Point Mutation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks