The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.
Abstract
Background Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.Methods We studied bronchoalveolar samples collected in 1989-99 from a prospective cohort of HIV-1-infected patients who had PCP. In 144 patients with 152 episodes of PCP, we analysed portions of DHPS using PCR and direct sequencing. The relation between survival, P. carinii DHPS mutations, and other predictors of treatment failure was assessed by Kaplan-Meier and multivariate Cox regression analysis.Findings P. carinii DHPS mutations were found in 31 (20.4%) of 152 PCP episodes. 3-month survival was significantly lower in patients infected with mutant P. carinii DHPS strains than in those with wild-type strains (p=0.002). After adjustment for other prognostic variables, presence of DHPS mutations remained the most important predictor of mortality (hazard ratio 3.1 [95% CI 1.2-8.1]). DHPS mutations were significantly more common in patients who had previous exposure to sulpha drugs (18 of 29 [62%]) than in those who had no exposure (13 of 123 [10.5%]; p<0.0001). A significant increase with time in the rate of DHPS mutations (p=0.01 for trend) was closely correlated with the rate of previous or current use of sulpha drugs as chemoprophylaxis.Interpretation Mutations in DHPS are associated with impaired prognosis in PCP, and may develop as a result of exposure to sulpha drugs.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Sulfa medications appear to exert selective pressure on Pneumocystis (18), as the DHPS gene is more likely to display mutations in highly conserved regions in patients with PCP who have previously been exposed to sulfa medications (19–25).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“Nevertheless, seven of the nine studies found that most HIV-infected patients with a diagnosis of PCP who had been prescribed TMP-SMX or dapsone for PCP prophylaxis had Pneumocystis that contained DHPS mutations (range 19%–80%, Table 2) (19–24,30).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“These DHPS gene mutations were rarely found in clinical isolates before the early 1990s (19,20,22).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“Several studies have consistently demonstrated a significant association between the use of TMP-SMX or dapsone for PCP prophylaxis in HIV-infected persons and the presence of DHPS gene mutations (Table 2) (19–25,30).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“In this study, DHPS mutation was the strongest predictor of death, and patients who had Pneumocystis that contained DHPS mutations had a greater than threefold increased risk for death within 3 months compared to patients with the wild-type DHPS, after important mortality cofactors such as age, CD4+/cell count, and arterial oxygen partial pressure (PaO2) were controlled for.”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“DHPS mutation was an independent predictor associated with increased deaths (OR = 3.1, p = 0.01).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“In fact, 12 (63%) of 19 PCP patients with Pneumocystis that contained DHPS gene mutations responded to PCP treatment with TMP-SMX.”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“In a multivariate analysis, Helweg-Larsen and colleagues found that DHPS mutations were an independent predictor associated with increased death rates (20).”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
In the citing paper
“19 patients with DHPS mutations were treated with TMP-SMX: 7 died; 12 (63%) responded and survived.”
From Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance (2004) · cites this paper as [20]
Citations
Cites
Triglia, T., Menting, J. G. T., Wilson, C. M., & Cowman, A. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13944 · Cited by 421
Hardy, W. D., Feinberg, J., Finkelstein, D. M., Power, M. E., He, W., Kaczka, C., Frame, P. T., Holmes, M., Waskin, H. A., Fass, R. J., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272604 · Cited by 344
Montaner, J. S. G., Lawson, L. M., Levitt, N., Belzberg, A., Schechter, M. T., & Ruedy, J. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-1-14 · Cited by 242
Weverling, G. J., Mocroft, A., Ledergerber, B., Kirk, O., Gonzales-Lahoz, J., Monforte, A. D., Proenca, R., Phillips, A. N., Lundgren, J. D., & Reiss, P. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03287-0 · Cited by 220
Self-citationDihydropteroate synthase polymorphisms in Pneumocystis carinii.
Lane, B. R., Ast, J. C., Hossler, P. A., Mindell, D. P., Bartlett, M. S., Smith, J. W., & Meshnick, S. R. (1997) · Journal of Infectious Diseases · doi:10.1093/infdis/175.2.482 · Cited by 176
Kazanjian, P., Locke, A. B., Hossler, P. A., Lane, B. R., Bartlett, M. S., Smith, J. W., Cannon, M., & Meshnick, S. R. (1998) · AIDS · doi:10.1097/00002030-199808000-00009 · Cited by 171
Brenner, M., Ognibene, F. P., Lack, E. E., Simmons, J. T., Suffredini, A. F., Lane, H. C., Fauci, A. S., Parrillo, J. E., Shelhamer, J. H., & Masur, H. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1199 · Cited by 157
Mason, G. R., Hashimoto, C. H., Dickman, P. S., Foutty, L. F., & Cobb, C. J. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.6.1336 · Cited by 141
Clusters of Pneumocystis carinii pneumonia: analysis of person-to- person transmission by genotyping
Helweg‐Larsen, J. (1998) · QJM · doi:10.1093/qjmed/91.12.813 · Cited by 114
Self-citationDallas, W. S., Gowen, J. E., Ray, P. H., Cox, M. J., & Dev, I. K. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.18.5961-5970.1992 · Cited by 111
Cited by
Sorted by citations
Thomas, C. F., & LIMPER, A. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032588 · Cited by 1,052
Epidemiology of Invasive Mycoses in North America
Pfaller, M. A., & Diekema, D. J. (2010) · Critical Reviews in Microbiology · doi:10.3109/10408410903241444 · Cited by 901
Sulfonamide resistance: mechanisms and trends.
Sköld, O. (2000) · Drug Resistance Updates · doi:10.1054/drup.2000.0146 · Cited by 647
A New Name for Pneumocystis from Humans and New Perspectives on the Host-Pathogen Relationship
Stringer, J. R., Beard, C. B., Miller, R. F., & Wakefield, A. E. (2002) · Emerging infectious diseases · doi:10.3201/eid0809.020096 · Cited by 488
Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients
Stern, A., Green, H., Paul, M., Vidal, L., & Leibovici, L. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005590.pub3 · Cited by 454
Colonization by Pneumocystis jirovecii and Its Role in Disease
Morris, A. M., & Norris, K. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-12 · Cited by 432
Alanio, A., Hauser, P. M., Lagrou, K., Melchers, W. J. G., Helweg‐Larsen, J., Matos, O., Cesaro, S., Maschmeyer, G., Einsele, H., Donnelly, J. P., et al. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw156 · Cited by 420
Self-citationCurrent insights into the biology and pathogenesis of Pneumocystis pneumonia
Thomas, C. F., & LIMPER, A. H. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1621 · Cited by 271
Rodríguez, M., & Fishman, J. A. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.770-782.2004 · Cited by 248
Beard, C. B., Carter, J. L., Keely, S. P., Huang, L., Pieniazek, N. J., Moura, I. N. S., Roberts, J. M., Hightower, A. W., Bens, M. S., Freeman, A. R., et al. (2000) · Emerging infectious diseases · doi:10.3201/eid0603.000306 · Cited by 241
Prophylaxis against Opportunistic Infections in Patients with Human Immunodeficiency Virus Infection
Kovacs, J. A., & Masur, H. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421907 · Cited by 232
Cooley, L., Dendle, C., Wolf, J., Teh, B. W., Chen, S. C., Boutlis, C., & Thursky, K. A. (2014) · Internal Medicine Journal · doi:10.1111/imj.12599 · Cited by 228
New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
Kovacs, J. A. (2001) · JAMA · doi:10.1001/jama.286.19.2450 · Cited by 214
Roblot, F., Godet, C., Moal, G. L., Garo, B., Souala, F., Dary, M., de Gentile, L., Gandji, J. A., Guimard, Y., Lacroix, C., et al. (2002) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-002-0758-5 · Cited by 203
Walzer, P. D., Evans, H. E. R., Copas, A. J., Edwards, S., Grant, A. D., & Miller, R. F. (2008) · Clinical Infectious Diseases · doi:10.1086/526778 · Cited by 197
HIV-Associated Pneumocystis Pneumonia
Huang, L., Cattamanchi, A., Davis, J. L., Boon, S. D., Kovacs, J., Meshnick, S., Miller, R. F., Walzer, P. D., Worodria, W., & Masur, H. (2011) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201009-062wr · Cited by 191
Mansharamani, N. G., Balachandran, D. D., Vernovsky, I., Garland, R. E., & Koziel, H. (2000) · CHEST Journal · doi:10.1378/chest.118.3.712 · Cited by 188
Evolving Health Effects of Pneumocystis
Kovacs, J. A., & Masur, H. (2009) · JAMA · doi:10.1001/jama.2009.880 · Cited by 176
Update on the diagnosis and treatment of Pneumocystis pneumonia
Carmona, E. M., & LIMPER, A. H. (2010) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465810380102 · Cited by 175
The Medical, Personal, and Social Causes of Uncertainty in HIV Illness
Brashers, D. E., Neidig, J. L., Russell, J. A., Cardillo, L. W., Haas, S. M., Dobbs, L. K., Garland, M., McCartney, B., & Nemeth, S. (2003) · Issues in Mental Health Nursing · doi:10.1080/01612840305292 · Cited by 183
Ledergerber, B., Mocroft, A., Reiss, P., Furrer, H., Kirk, O., Bickel, M., Uberti‐Foppa, C., Pradier, C., Monforte, A. D., Schneider, M. M. E., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101183440302 · Cited by 165
Self-citationKazanjian, P., Armstrong, W., Hossler, P. A., Burman, W., Richardson, J., Lee, C., Crane, L., Katz, J., & Meshnick, S. R. (2000) · The Journal of Infectious Diseases · doi:10.1086/315719 · Cited by 164
Huang, L., Beard, C. B., Creasman, J., Levy, D., Duchin, J. S., Lee, S., Pieniazek, N., Carter, J. L., del Rio, C., Rimland, D., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315824 · Cited by 149
Pneumocystis jirovecii Pneumonia in the Non–HIV-Infected Population
Avino, L. J., Naylor, S. M., & Roecker, A. M. (2016) · Annals of Pharmacotherapy · doi:10.1177/1060028016650107 · Cited by 148
Dumoulin, A., Mazars, E., Séguy, N., Gargallo‐Viola, D., Vargas, S. L., Cailliez, J. C., Aliouat, E. M., Wakefield, A. E., & Dei‐Cas, E. (2000) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960000354 · Cited by 135
Castro, N. D., Neuville, S., Sarfati, C., Ribaud, P., Derouin, F., Gluckman, É., Socié, G., & Molina, J. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705149 · Cited by 134
Huang, L., Morris, A. M., LIMPER, A. H., Beck, J. M., & Participants, O. B. O. T. A. P. W. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200602-015ms · Cited by 133
Wislez, M., Bergot, E., Antoine, M., Parrot, A., Carette, M., Mayaud, C. M., & Cadranel, J. L. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2007034 · Cited by 132
Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance
Huang, L., Crothers, K., Atzori, C., Benfield, T., Miller, R., Rabodonirina, M., & Helweg-Larsen, J. (2004) · Emerging Infectious Diseases · doi:10.3201/eid1010.030994 · Cited by 131
“These DHPS gene mutations were rarely found in clinical isolates before the early 1990s (19,20,22).”
BackgroundMethodSelf-citationRuffini, D. D., & Madhi, S. A. (2002) · AIDS · doi:10.1097/00002030-200201040-00013 · Cited by 131
Navin, T. R., Beard, C. B., Huang, L., del Rio, C., Lee, S., Pieniazek, N. J., Carter, J. L., Le, T., Hightower, A., & Rimland, D. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05705-1 · Cited by 117
Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men
Morris, A. M., Kingsley, L., Groner, G., Lebedeva, I. P., Beard, C. B., & Norris, K. A. (2004) · AIDS · doi:10.1097/00002030-200403260-00011 · Cited by 113
Crothers, K. A., Beard, C. B., Turner, J., Groner, G., Fox, M., Morris, A. M., Eiser, S., & Huang, L. (2005) · AIDS · doi:10.1097/01.aids.0000168974.67090.70 · Cited by 112
Quality measures of antimicrobial drug use
Gyssens, I. C. (2001) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00208-9 · Cited by 112
Rabodonirina, M., Vanhems, P., Couray‐Targe, S., Gillibert, R.-P., Ganne, C., Nizard, N., Colin, C., Fabry, J., Touraine, J. L., van Melle, G., et al. (2004) · Emerging infectious diseases · doi:10.3201/eid1010.040453 · Cited by 111
Matsumura, Y., Shindo, Y., Iinuma, Y., Yamamoto, M., Shirano, M., Matsushima, A., Nagao, M., Ito, Y., Takakura, S., Hasegawa, Y., et al. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-76 · Cited by 110
Aspinall, T. V., Joynson, D. H. M., Guy, E. C., Hyde, J. E., & Sims, P. F. G. (2002) · The Journal of Infectious Diseases · doi:10.1086/340577 · Cited by 109
Pneumocystisinfection in humans: diagnosis and treatment
Calderón, E. J., Rivero, S. G., Durand-Joly, I., & Dei‐Cas, E. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.42 · Cited by 107
Pulmonary Complications of HIV Infection
Beck, J. M., Rosen, M. J., & PEAVY, H. H. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.11.2102047 · Cited by 106
Helweg‐Larsen, J., Benfield, T., Atzori, C., & Miller, R. F. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp372 · Cited by 98
Self-citationCurtis, J. R., Yarnold, P. R., Schwartz, D. N., Weinstein, R. A., & Bennett, C. L. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9909014 · Cited by 97
A Molecular Window into the Biology and Epidemiology of Pneumocystis spp
Ma, L., Cissé, O. H., & Kovacs, J. A. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00009-18 · Cited by 98
Update on the epidemiology and transmission of Pneumocystis carinii
Morris, A. M., Beard, C. B., & Huang, L. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(01)01514-3 · Cited by 90
Pneumocystis carinii pneumonia in patients with hematologic malignancies: a descriptive study
Roblot, F. (2003) · Journal of Infection · doi:10.1016/s0163-4453(03)00038-0 · Cited by 87
Kazanjian, P. H., Armstrong, W. S., Hossler, P. A., Huang, L., Beard, C. B., Carter, J. V., Crane, L. R., Duchin, J. S., Burman, W. J., Richardson, J. D., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/318835 · Cited by 87
Pneumocystis jiroveci Genotypes in the Spanish Population
Cano, M. A. M., de la Horra, C., Martín‐Juan, J., VARELA, J. M., Torronteras, R., RESPALDIZA, N., Medrano, F. J., & Calderón, E. J. (2004) · Clinical Infectious Diseases · doi:10.1086/421778 · Cited by 83
Rogers, T. R., Verweij, P. E., Castanheira, M., Dannaoui, E., White, P. L., Arendrup, M. C., Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST), Arendrup, M. C., Arikan-Akdagli, S., Barchiesi, F., et al. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac161 · Cited by 82
Pneumocystis infections: the iceberg?
Dei‐Cas, E. (2000) · Medical Mycology · doi:10.1080/mmy.38.s1.23.32 · Cited by 80
Molecular diagnosis ofPneumocystispneumonia
Durand-Joly, I., Chabé, M., Soula, F., Delhaès, L., Camus, D., & Dei‐Cas, E. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2005.06.006 · Cited by 77
Pneumocystis Pneumonia: Current Concepts in Pathogenesis, Diagnosis, and Treatment
Krajicek, B. J., Thomas, C. F., & Limper, A. H. (2009) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2009.02.005 · Cited by 73
Polymerase chain reaction detection of Pneumocystis jiroveci: evaluation of 9 assays
Robberts, F. J. L., Liebowitz, L. D., & Chalkley, L. J. (2007) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2007.02.014 · Cited by 73
Imaging lung manifestations of HIV/AIDS
Khan, A., Allen, C., AL-Jahdali, H., Irion, K., Ghanem, S. A., & Gouda, A. (2010) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.69106 · Cited by 72
Nahimana, A., Rabodonirina, M., Zanetti, G., Meneau, I., Francioli, P., Bille, J., & Hauser, P. M. (2003) · The Journal of Infectious Diseases · doi:10.1086/378239 · Cited by 71
Pneumocystis jirovecii multilocus genotyping profiles in patients from Portugal and Spain
Esteves, F., Montes-Cano, M., de la Horra, C., Costa, M. C., Calderón, E. J., Antunes, F., & Matos, O. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01944.x · Cited by 71
Takahashi, T., Hosoya, N., Endo, T., Nakamura, T., Sakashita, H., Kimura, K., Ohnishi, K., Nakamura, Y., & Iwamoto, A. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.9.3161-3164.2000 · Cited by 69
Strain Typing Methods and Molecular Epidemiology ofPneumocystisPneumonia
Beard, C. B., Roux, P., Nevez, G., Hauser, P. M., Kovacs, J. A., Unnasch, T. R., & Lundgren, B. (2004) · Emerging infectious diseases · doi:10.3201/eid1010.030981 · Cited by 68
Self-citationTherapy and Management of Pneumocystis jirovecii Infection
White, P. L., Price, J. S., & Backx, M. (2018) · Journal of Fungi · doi:10.3390/jof4040127 · Cited by 68
Prognostic Markers of Short-term Mortality in AIDS-Associated Pneumocystis carinii Pneumonia
Benfield, T., Helweg‐Larsen, J., Bang, D., Lundgren, J. D., & Junge, J. (2001) · CHEST Journal · doi:10.1378/chest.119.3.844 · Cited by 67
Self-citationA persistent challenge: the diagnosis of respiratory disease in the non-AIDS immunocompromised host
Mayaud, C. M. (2000) · Thorax · doi:10.1136/thorax.55.6.511 · Cited by 66
Ma, L., Kovacs, J. A., Cargnel, A., Valerio, A., Fantoni, G., & Atzori, C. (2002) · The Journal of Infectious Diseases · doi:10.1086/340220 · Cited by 61
Treatment ofPneumocystis jiroveciipneumonia in HIV-infected patients: a review
Huang, Y., Yang, J.-J., Lee, N., Chen, G., Ko, W., Sun, H., & Hung, C. (2017) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1364991 · Cited by 60
Ponce, C. A., Chabé, M., George, C., Cárdenas, A., Durán, L., Guerrero, J., Bustamante, R. I., Matos, O., Huang, L., Miller, R. F., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01290-16 · Cited by 58
Effects of six anti-hypertensive medications on cognitive performance
Muldoon, M. F., Waldstein, S. R., Ryan, C. M., Jennings, J. R., Polefrone, J. M., Shapiro, A. P., & Manuck, S. B. (2002) · Journal of Hypertension · doi:10.1097/00004872-200208000-00028 · Cited by 56
Calder�n, E., de la Horra, C., Medrano, F. J., L�pez-Su�rez, A., Montes-Cano, M., RESPALDIZA, N., Elvira-Gonz�lez, J., Martín‐Juan, J., Bascu�ana, A., & VARELA, J. M. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1151-3 · Cited by 56
Prophylaxis and treatment of Pneumocystis Jirovecii pneumonia after solid organ transplantation
Brakemeier, S., Pfau, A. C., Zukunft, B., Budde, K., & Nickel, P. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.06.010 · Cited by 54
Helweg‐Larsen, J., Lee, C., Jin, S., Hsueh, J. Y.-C., Benfield, T., Hansen, J. E., Lundgren, J. D., & Lundgren, B. (2001) · AIDS · doi:10.1097/00002030-200103090-00003 · Cited by 54
Self-citationSulfa Use, Dihydropteroate Synthase Mutations, andPneumocystis jiroveciiPneumonia
Stein, C. R., Poole, C., Kazanjian, P. H., & Meshnick, S. R. (2004) · Emerging infectious diseases · doi:10.3201/eid1010.040362 · Cited by 53
Visconti, E., Ortona, E., Mencarini, P., Margutti, P., Marinaci, S., Zolfo, M., Siracusano, A., & Tamburrini, E. (2001) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(01)00460-5 · Cited by 50
The Changing Epidemiology of HIV-Infected Patients in the Intensive Care Unit
Akgün, K. M., Pisani, M. A., & Crothers, K. A. (2011) · Journal of Intensive Care Medicine · doi:10.1177/0885066610387996 · Cited by 50
Kazanjian, P. H., Fisk, D. T., Armstrong, W. S., Shulin, Q., Liwei, H., Ke, Z., & Meshnick, S. R. (2004) · The Journal of Infectious Diseases · doi:10.1086/382957 · Cited by 50
Sulfa Resistance and Dihydropteroate Synthase Mutants in RecurrentPneumocystis cariniiPneumonia
Nahimana, A., Rabodonirina, M., Helweg‐Larsen, J., Meneau, I., Francioli, P. B., Billé, J., & Hauser, P. M. (2003) · Emerging infectious diseases · doi:10.3201/eid0907.020753 · Cited by 50
Self-citationEsteves, F., Gaspar, J., Marques, T., Baptista‐Leite, R., Antunes, F., Mansinho, K., & Matos, O. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.03030.x · Cited by 49
Álvarez-Martínez, M. J., Moreno, A., Miró, J. M., Valls, M. E., Rivas, P. V., de Lazzari, E., Sued, O. G., Benito, N., Domingo, P., Ribera, E., et al. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.04.016 · Cited by 49
Genotyping of Pneumocystis jiroveci Pneumonia in Italian AIDS Patients
Valerio, A., Tronconi, E., Mazza, F., Fantoni, G., Atzori, C., Tartarone, F., Duca, P., & Cargnel, A. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3180decbe2 · Cited by 48
Iliades, P., Meshnick, S. R., & Macreadie, I. G. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2617-2623.2004 · Cited by 48
van Hal, S. J., Gilgado, F., Doyle, T., Barratt, J., Stark, D. J., Meyer, W., & Harkness, J. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.02102-08 · Cited by 47
Hauser, P. M., Nahimana, A., Taffé, P., Weber, R. K., Francioli, P. B., Billé, J., & Rabodonirina, M. (2010) · Clinical Infectious Diseases · doi:10.1086/655145 · Cited by 47
Dworkin, M. S., Hanson, D. L., Navin, T. R., & Adult and Adolescent Spectrum HIV Disease Project (2001) · The Journal of Infectious Diseases · doi:10.1086/319866 · Cited by 47
Stringer, J. R. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00222 · Cited by 45
Pneumocystis carinii pneumonia: a review of current issues in diagnosis and management
Barry, S. M., & Johnson, M. (2001) · HIV Medicine · doi:10.1046/j.1468-1293.2001.00062.x · Cited by 44
Alves, C. L., Nicolas, J. M., Miró, J. M., Torres, A., Agustı́, C., González, J., Rañó, A., Benito, N., Moreno, A., García, F., et al. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.17100870 · Cited by 43
Dini, L., du Plessis, M., Frean, J., & Fernandez, V. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02004-09 · Cited by 42
Esteves, F., Gaspar, J., de Sousa, B. C., Antunes, F., Mansinho, K., & Matos, O. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02303-10 · Cited by 42
Totet, A., Latouche, S., Lacube, P., Pautard, J., Jounieaux, V., Raccurt, C. P., Roux, P., & Nevez, G. (2004) · Emerging infectious diseases · doi:10.3201/eid1004.030451 · Cited by 41
Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials
Swarbrick, J., Iliades, P., Simpson, J. S., & Macreadie, I. G. (2008) · The Open Enzyme Inhibition Journal · doi:10.2174/1874940200801010012 · Cited by 41
Castro, J. G., & Morrison-Bryant (2010) · HIV/AIDS - Research and Palliative Care · doi:10.2147/hiv.s7720 · Cited by 40
Meneau, I., Sanglard, D., Billé, J., & Hauser, P. M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2610-2616.2004 · Cited by 40
Lu, J., & Lee, C. (2008) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(08)60199-0 · Cited by 39
Mutations in the Pneumocystis jirovecii DHPS Gene Confer Cross-Resistance to Sulfa Drugs
Iliades, P., Meshnick, S. R., & Macreadie, I. G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.741-748.2005 · Cited by 38
Rabodonirina, M., Vaillant, L., Taffé, P., Nahimana, A., Gillibert, R.-P., Vanhems, P., & Hauser, P. M. (2012) · Emerging infectious diseases · doi:10.3201/eid1901.120140 · Cited by 37
Sköld, O. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.117 · Cited by 37
Pneumocystis jiroveci Pneumonia in Adult Patients with AIDS
Patel, N. R., & Koziel, H. (2004) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200403060-00005 · Cited by 35
Ma, L., & Kovacs, J. A. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3213-3215.2001 · Cited by 34
Coutsoudis, A., Pillay, K., Spooner, E., Coovadia, H. M., Pembrey, L., & Newell, M. (2005) · PubMed · Cited by 34
Taylor, S. M., Meshnick, S. R., Worodria, W. O., Andama, A. O., Cattamanchi, A., Davis, J. L., Yoo, S., Byanyima, P., Kaswabuli, S., Goodman, C. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049991 · Cited by 33
Helweg‐Larsen, J., Lundgren, B., & Lundgren, J. D. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.10.3789-3792.2001 · Cited by 33
Self-citationPneumocystis Jirovecii Multilocus Gene Sequencing: Findings And Implications
Matos, O., & Esteves, F. (2010) · Future Microbiology · doi:10.2217/fmb.10.75 · Cited by 33
Update on lung disease in AIDS
Boiselle, P. M., Aviram, G., & Fishman, J. E. (2002) · Seminars in Roentgenology · doi:10.1053/sroe.2002.29586 · Cited by 33
Helweg‐Larsen, J. (2000) · Scandinavian Journal of Infectious Diseases · doi:10.1080/003655400458730 · Cited by 33
Self-citationGingo, M. R., Lucht, L. A., Daly, K. R., Djawe, K., Palella, F. J., Abraham, A. G., Bream, J. H., Witt, M. D., Kingsley, L., Norris, K. A., et al. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182167516 · Cited by 32
Metadata
- Authors
- Helweg-Larsen, J., Benfield, T. L., Eugen-Olsen, J., Lundgren, J. D., & Lundgren, B.
- Affiliations
- University of Copenhagen (DK)
- Statens Serum Institut (DK)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 354
- Issue
- 9187
- Pages
- 1347-1351
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2076316807
- Cited by
- 274
- References
- 30
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 10
- FWCI
- 18.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- Pneumocystis carinii pneumonia, dihydropteroate synthase, dhps mutations, HIV-1 infection, AIDS, survival, mortality, chemoprophylaxis, folate biosynthesis, treatment failure
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Dihydropteroate Synthase, Drug Resistance, Microbial, Genotype, Humans, Middle Aged, Pneumocystis, Pneumonia, Pneumocystis, Prognosis, Recurrence, Regression Analysis, Sulfamethoxazole, Cohort Studies, HIV-1, Survival Analysis, Polymerase Chain Reaction, AIDS-Related Opportunistic Infections, Point Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
