Cited by 555Bone Tissue Engineering MaterialsHydrogels: synthesis, properties, applicationsbiodegradable polymer synthesis and properties

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Injectable biodegradable materials for orthopedic tissue engineering

Temenoff, Johnna S, Mikos, Antonios G·2000·Biomaterials

DOI 10.1016/s0142-9612(00)00108-3

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Abstract

The large number of orthopedic procedures performed each year, including many performed arthroscopically, have led to great interest in injectable biodegradable materials for regeneration of bone and cartilage. A variety of materials have been developed for these applications, including ceramics, naturally derived substances and synthetic polymers. These materials demonstrate overall biocompatibility and appropriate mechanical properties, as well as promote tissue formation, thus providing an important step towards minimally invasive orthopedic procedures. This review provides a comparison of these materials based on mechanical properties, biocompatibility and regeneration efficacy. Advantages and disadvantages of each material are explained and design criteria for injectable biodegradable systems are provided.

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Authors: Temenoff, J. S., & Mikos, A. G.
Affiliations: Rice University (US)
Corresponding author: Mikos, Antonios G
ORCID: Temenoff, Johnna S
Mikos, Antonios G
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2000-12
Volume: 21
Issue: 23
Pages: 2405-2412
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/s0142-9612(00)00108-3
OpenAlex: W2062224667
Cited by: 554
References: 71
Citations by year: 2026: 4 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 20 · 2018: 18 · 2017: 26 · 2016: 29 · 2015: 24 · 2014: 34 · 2013: 24 · 2012: 32
FWCI: 12.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Badan Riset dan Inovasi Nasional
National Institutes of Health (5r01ar044381-04, 5r01de013031-05)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR44381)
National Institute of Dental and Craniofacial Research (R01 DE13031)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords: orthopedic tissue engineering, bone regeneration, cartilage regeneration, biocompatibility, mechanical properties, ceramic scaffolds, natural polymers, synthetic polymers, tissue regeneration
MeSH terms: Animals, Biocompatible Materials, Biodegradation, Environmental, Bone and Bones, Cartilage, Orthopedics, Rabbits, Rats

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Injectable biodegradable materials for orthopedic tissue engineering

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