The DOI matches its Crossref record; 68 of the 71 references it cites were found in a registry or an index.
Injectable biodegradable materials for orthopedic tissue engineering
Abstract
The large number of orthopedic procedures performed each year, including many performed arthroscopically, have led to great interest in injectable biodegradable materials for regeneration of bone and cartilage. A variety of materials have been developed for these applications, including ceramics, naturally derived substances and synthetic polymers. These materials demonstrate overall biocompatibility and appropriate mechanical properties, as well as promote tissue formation, thus providing an important step towards minimally invasive orthopedic procedures. This review provides a comparison of these materials based on mechanical properties, biocompatibility and regeneration efficacy. Advantages and disadvantages of each material are explained and design criteria for injectable biodegradable systems are provided.
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In the citing paper
“The copolymers degrade to propylene glycol, poly(acrylic acidco-fumaric acid) and fumaric acid”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
In the citing paper
“A number of studies have reported on the synthesis, properties (Kharas et al., 1997;Peter et al., 1998a;Temenoff and Mikos, 2000) and in-vivo degradation (Yaszemski et al., 1994;Frazier et al., 1997;Peter et al., 1998a) characteristics of poly(propylene fumarate).”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
In the citing paper
“A number of methods have been reported to prepare PPF, and each results in different polymer properties”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos 2000
In the citing paper
“PPF based degradable polymer compositions including injectable biodegradable materials have been reported in the literature”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
In the citing paper
“ß-TCP was particularly useful for reinforcement, and compositions without TCP reinforcement disintegrated very early in the implant”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
In the citing paper
“Accordingly, combinations of different amounts of these monomers would result in polymer with degradation properties custom-designed for a specific application”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Temenoff and Mikos, 2000
Citations
Cites
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Cited by
Sorted by citations
Hydrogels for Tissue Engineering
Lee, K. Y., & Mooney, D. J. (2001) · Chemical Reviews · doi:10.1021/cr000108x · Cited by 5,295
Biodegradable polymers as biomaterials
Nair, L. S., & Laurencin, C. T. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.017 · Cited by 4,416
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Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765
“A number of methods have been reported to prepare PPF, and each results in different polymer properties (Peter et al., 1997a,b, 1999; Temenoff and Mikos 2000).”
BackgroundMethodInfluentialBioactive modification of poly (ethylene glycol) hydrogels for tissue engineering
Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457
Metadata
- Authors
- Temenoff, J. S., & Mikos, A. G.
- Affiliations
- Rice University (US)
- Corresponding author
- Mikos, Antonios G
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 21
- Issue
- 23
- Pages
- 2405-2412
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2062224667
- Cited by
- 554
- References
- 71
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 20 · 2018: 18 · 2017: 26 · 2016: 29 · 2015: 24 · 2014: 34 · 2013: 24 · 2012: 32
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Badan Riset dan Inovasi Nasional
- National Institutes of Health (5r01ar044381-04, 5r01de013031-05)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR44381)
- National Institute of Dental and Craniofacial Research (R01 DE13031)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- orthopedic tissue engineering, bone regeneration, cartilage regeneration, biocompatibility, mechanical properties, ceramic scaffolds, natural polymers, synthetic polymers, tissue regeneration
- MeSH terms
- Animals, Biocompatible Materials, Biodegradation, Environmental, Bone and Bones, Cartilage, Orthopedics, Rabbits, Rats
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