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Cited by 91biodegradable polymer synthesis and propertiesPolymer Foaming and CompositesBone Tissue Engineering Materials

The DOI matches its Crossref record.

Solvent-free fabrication of micro-porous polyurethane amide and polyurethane-urea scaffolds for repair and replacement of the knee-joint meniscus

Spaans, C.J, Belgraver, V.W, Rienstra, O, de Groot, J.H, Veth, R.P.H, Pennings, A.J·2000·Biomaterials
DOI 10.1016/s0142-9612(00)00113-7
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Abstract

New porous polyurethane urea and polyurethane amide scaffolds for meniscal reconstruction have been developed in a solvent-free process. As soft segments, copolymers of 50/50 L-lactide/epsilon-caprolactone have been used. After terminating the soft segment with diisocyanates, chain extension was performed with adipic acid and water. Reaction between the isocyanate groups and adipic acid or water provides carbon dioxide and results in a porous polymer. Extra hydroxyl-terminated prepolymer was added in order to regulate the amount of carbon dioxide formed in the foaming reaction. Furthermore, salt crystals ranging in size from 150 to 355 microm were added in order to induce macroporosity. The pore size was regulated by addition of surfactant and by the use of ultrasonic waves. The resulting porous polymer scaffolds exhibit good mechanical properties like a high-compression modulus of 150 kPa. Chain extension with adipic acid results in better mechanical properties due to better defined hard segments. This results from the lower nucleophilicity of carboxylic acids compared to water and alcohols. By adjusting the reaction conditions, materials in which macropores are interconnected by micropores can be obtained. On degradation only non-toxic products will be released; importantly, the materials were obtained by a simple, reproducible and solvent-free procedure.

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  • Micro-porous polyurethane amide and polyurethaneurea scaffolds with porosity of 70 to 80% were achieved by a technique using salt crystals and surfactants with ultrasonic waves.

    “Porous scaffolds with porosity of 70 to 80% were achieved by this technique.”

    From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Spaans et al. (2000)

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Research works printed but not linked: 24

  1. Leenslag, 1984, A porous composite, based on a biodegradable poly(l-lactide)-polyurethane matrix and reinforced with carbon fibres, for reconstruction of meniscal lesions, Makromol Chem Rapid Commun, 5, 815, 10.1002/marc.1984.030051207 · DOI
  2. Veth, 1986, Experimental meniscal lesions reconstructed with a carbon fibre polyurethane-poly(l-lactide) graft, Clin Orthop Rel Res, 202, 286, 10.1097/00003086-198601000-00041 · DOI
  3. Elema, 1990, Use of prorous biodegradable polymer implants in meniscus reconstruction. 2) Biological evaluation of porous biodegradable polymer implants in menisci, Colloid Polym Sci, 268, 1082, 10.1007/BF01410673 · DOI
  4. de Groot, 1990, Use of porous biodegradable polymer implants in meniscus reconstruction. 1) Preparation of porous biodegradable polyurethanes for the reconstruction of the meniscus, Colloid Polym Sci, 268, 1073, 10.1007/BF01410672 · DOI · Paper page
  5. de Groot, 1997, Meniscal tissue regeneration in porous 50/50 copoly(l-lactide/ε-caprolactone) implants, Biomaterials, 18, 613, 10.1016/S0142-9612(96)00169-X · DOI
  6. de Groot, 1997, A novel method for fabrication of biodegradable scaffolds with high compression moduli, J Mater Sci: Mater Med, 8, 707, 10.1023/A:1018544124990 · DOI
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  12. de Groot, 1998, On the role of aminolysis and transesterification in the synthesis of ε-caprolactone and l-lactide based polyurethanes, Polym Bull, 41, 299, 10.1007/s002890050366 · DOI
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  18. Spaans, 1999, Development of new poly(urethane)s for repair and replacement of the knee joint meniscus, Polym Prepr, 40, 589
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Metadata

Authors
Spaans, C. J., Belgraver, V. W., Rienstra, O., de Groot, J. H., Veth, R. P. H., & Pennings, A. J.
Affiliations
  • University of Groningen (NL)
  • Radboud University Nijmegen (NL)
Corresponding author
Pennings, A.J
Venue
Biomaterials
Publisher
Elsevier BV
Published
2000-12
Volume
21
Issue
23
Pages
2453-2460
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/s0142-9612(00)00113-7
OpenAlex
W2025977396
Cited by
91
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer Foaming and Composites
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
poly(urethane-urea), porous scaffolds, meniscal reconstruction, knee joint, solvent-free processing, chain extension, adipic acid, carbon dioxide formation, surfactants, pore size control, mechanical properties, biodegradation, tissue engineering scaffolds
MeSH terms
Knee Injuries, Knee Joint, Microscopy, Electron, Polyurethanes

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