The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Characterization of a bovine collagen–hydroxyapatite composite scaffold for bone tissue engineering
Abstract
Different biomaterials have been used as scaffolds for bone tissue engineering. Here we characterize a biomaterial composed of sintered (1100 degrees C) and powdered hydroxyapatite (HA) and type I collagen (Coll), both of bovine origin, designed for osteoconductive and osteoinductive scaffolds. Coll/HA proportions were 1/2.6 and 1/1 (wet weight), and particles sizes varied from 200 to 400 microm. Vv (volume density) and Sv (surface to volume density) for the HA particles in the composite ranged from 0.48 +/- 0.06 to 0.55 +/- 0.02 and 5.090 +/- 0.545 to 6.366 +/- 0.289 microm(-1), respectively. Due to the relatively small changes in Vv and Sv, a macroporosity could be characterized for the biocomposite. X-ray diffraction and infrared spectroscopy showed that the sintered bone was composed essentially of HA with minimum additional groups such as surface calcium hydroxide, surface and crystal water, free carbon dioxide and possibly brushite. Mass spectrometry detected carbonates at A and B sites of HA, and weakly bound to the structure. Human osteoblasts adhered and spread on both the HA particle surface and the collagen fibers, which seemed to guide cells between adjacent particles. The biocomposite studied has several characteristics considered as ideal for its use as a scaffold for osteoconduction and osteoinduction.
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“adhering capacity of cells, differentiation, integration, and viability of the cells in the vicinity of the scaffold are enhanced [46,56].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [56]
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Cites
Osteoblast adhesion on biomaterials
Anselme, K. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00242-2 · Cited by 2,509
Suchanek, W. L., & Yoshimura, M. (1998) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/jmr.1998.0015 · Cited by 2,046
Biomaterial developments for bone tissue engineering
Burg, K. J. L., Porter, S. E., & Kellam, J. F. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00102-2 · Cited by 1,665
Role of material surfaces in regulating bone and cartilage cell response
Boyan, B. D., Hummert, T. W., Dean, D. D., & Schwartz, Z. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85758-9 · Cited by 1,331
Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function
Ducheyne, P., & Qiu, Q. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00181-7 · Cited by 1,136
Deligianni, D. D., Katsala, N. D., Koutsoukos, P. G., & Missirlis, Y. F. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00174-5 · Cited by 1,111
Role of morphogenetic proteins in skeletal tissue engineering and regeneration
Reddi, A. H. (1998) · Nature Biotechnology · doi:10.1038/nbt0398-247 · Cited by 831
Pore Size of Porous Hydroxyapatite as the Cell-Substratum Controls BMP-Induced Osteogenesis
Tsuruga, E., Takita, H., Itoh, H., Wakisaka, Y., & Kuboki, Y. (1997) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021589 · Cited by 706
Bone Morphogenetic Protein and Bone Morphogenetic Protein Gene Family in Bone Formation and Repair
Wozney, J. M., & Rosen, V. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199801000-00006 · Cited by 611
Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo
Lu, J. X., Flautre, B., Anselme, K., Hardouin, P., Gallur, A., Descamps, M., & Thierry, B. (1999) · Journal of Materials Science Materials in Medicine · doi:10.1023/a:1008973120918 · Cited by 536
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Research works printed but not linked: 2
- Underwood EE. Quantitative stereology. Reading, MA: Addison-Wesley Publishing Company; 1970. p. 274.
- Lawson, 1998, Collagen–calcium phosphate composites, Proc Instr Mech Eng, 212, 413, 10.1243/0954411981534187 · DOI
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Cunniffe, G. M., Dickson, G. R., Partap, S., Stanton, K. T., & O’Brien, F. J. (2010) · Journal of Materials Science: Materials in Medicine · doi:10.1007/s10856-009-3964-1 · Cited by 199
Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57
Semyari, H., Salehi, M., Taleghani, F., Ehterami, A., Bastami, F., Jalayer, T., Semyari, H., Hamed Nabavi, M., & Semyari, H. (2018) · Journal of Biomaterials Applications · doi:10.1177/0885328218805229 · Cited by 45
Biomimetic synthesis of collagen/nano-hydroxyapitate scaffold for tissue engineering
Liu, C.-Z. (2008) · Journal of Bionic Engineering · doi:10.1016/s1672-6529(08)60064-5 · Cited by 21
Metadata
- Authors
- Rodrigues, C. V. M., Serricella, P., Linhares, A. B. R., Guerdes, R. M., Borojevic, R., Rossi, M. A., Duarte, M. E. L., & Farina, M.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Corresponding author
- Farina, M.
- ORCID
- Linhares, A.B.R.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 24
- Issue
- 27
- Pages
- 4987-4997
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2012581546
- Cited by
- 322
- References
- 41
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 19 · 2021: 11 · 2020: 16 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 18 · 2015: 25 · 2014: 26 · 2013: 17 · 2012: 17
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- hydroxyapatite/collagen composite, bone tissue engineering, scaffolds, hydroxyapatite, sintering, macroporosity, osteoconduction, osteoinduction, brushite
- MeSH terms
- Animals, Cattle, Cells, Cultured, Humans, Manufactured Materials, Materials Testing, Osteoblasts, Powders, Surface Properties, Osseointegration, Durapatite, Bone Substitutes, Tissue Engineering, Collagen Type I
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