The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Compensatory placental growth after restricted maternal nutrition in early pregnancy
Open accessAbstract
This study examined the effects of undernutrition in pregnancy on fetal and placental growth among infants born in 1944-1946 in The Netherlands, including infants born during the war-induced Dutch famine of 1944-1945. There was an increase in placental weight, but not in birthweight, in infants whose mothers' nutrition was compromised around conception or in the first trimester of pregnancy. Therefore, the placental index was also increased. Compared to pre-famine controls, the relative increase after first trimester exposure to undernutrition was larger in the northern part of the country (5.2 per cent, 95 per cent confidence interval 1.4, 9.0) where nutritional deprivation was presumably moderate compared to the west (3.5 per cent, 95 per cent confidence interval 0.2, 7.2) where nutritional deprivation was severe. The increase in placental weight is interpreted as compensatory for the reduction in maternal caloric intake. Whereas this suggests that pregnancy undernutrition can stimulate compensatory placental growth, the latter was only seen after first trimester undernutrition, which does not affect infant size at birth. For these infants, therefore, birthweight is not an appropriate proxy measure of undernutrition in pregnancy. These factors need to be considered in future studies relating pregnancy nutrition to adult health outcomes.
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“In the Dutch hunger winter populations, placental weight at term was increased when the famine occurred in the 1 st trimester but was reduced, along with infant birth weight, in women who were in their 3 rd trimester at the time of the famine (350, 471).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [350]
In the citing paper
“However, despite this, placental efficiency measured as the fetal to placental weight ratio was greater in response to the undernutrition in late pregnancy than seen in control pregnancies before the famine (350,”
From Placental Origins of Chronic Disease (2016) · cites this paper as [350]
In the citing paper
“The size of the human placenta at term is known to be affected by the calorie intake and dietary composition during the pregnancy (216, 350, 471).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [350]
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Metadata
- Authors
- Lunney, L. H.
- Affiliations
- Institute for Cancer Prevention (US)
- Corresponding author
- Lunney, L.H.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 19
- Issue
- 1
- Pages
- 105-111
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2024706817
- Cited by
- 164
- References
- 38
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 9 · 2016: 4 · 2015: 14 · 2014: 5 · 2013: 3 · 2012: 16
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Placenta (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd026492-02)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1RO1-HD26492-02)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- placental development, maternal undernutrition, early pregnancy, Dutch famine, fetal growth, birth weight, fetal programming, adult health outcomes
- MeSH terms
- Adult, Birth Weight, Female, Humans, Netherlands, Nutrition Disorders, Organ Size, Placentation, Pregnancy, Pregnancy Complications, Pregnancy Trimester, First, Starvation, History, 20th Century
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