CoChat
Sign Up
Cited by 197Endoplasmic Reticulum Stress and DiseaseIon Channels and ReceptorsRNA and protein synthesis mechanisms

Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptability

Brostrom, Margaret A, Brostrom, Charles O·2003·Cell Calcium
DOI 10.1016/s0143-4160(03)00127-1
Open this paper in CoChat — free account

Abstract

The endoplasmic reticulum (ER) possesses the structural and functional features expected of an organelle that supports the integration and coordination of major cellular processes. Ca(2+) sequestered within the ER sustains lumenal protein processing while providing a reservoir of the cation to support stimulus-response coupling in the cytosol. Release of ER Ca(2+) sufficient to impair protein processing promotes ER stress and signals the "unfolded protein response" (UPR). The association of the UPR with an acute suppression of mRNA translational initiation and a longer term up-regulation of ER chaperones and partial translational recovery is discussed. Regulatory sites in mRNA translation and the mechanisms responsible for the early and later phases of the UPR are reviewed. The regulatory significance of GRP78/BiP, a multifunctional, broad-specificity ER chaperone, in the coordination of ER protein processing with mRNA translation during acute and chronic ER stress is addressed. The relationship of ER stress to protein misfolding in the cytoplasm is examined. Translational alterations in embryonic cardiomyocytes during treatments with various Ca(2+)-mobilizing, growth-promoting stimuli are described. The importance of ER Ca(2+) stores, ER chaperones, and cytosolic-free Ca(2+) in translational control and growth promotion by these stimuli is assessed. Some perspectives are provided regarding Ca(2+) as an integrating factor in the generation or diversion of metabolic energy. Circumstances impacting upon cellular adaptability during exposure to growth stimuli or during stressful conditions that require rapid adjustments in ATP for continued viability are considered.

Integrity signals

Registry

Crossref · 10.1016/s0143-4160(03)00127-1

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • ER stress can be detrimental to fungal cells if ER function is not restored because the ER is key in protein processing and Ca2+ signaling.

    “ER stress can be detrimental to fungal cells if ER function is not restored because in addition to its crucial role in the posttranslational processing of proteins, the ER is also a key player in Ca 2ϩ signaling (32).”

    From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [32]

  • In eukaryotes, the ER constitutes a finite reservoir of Ca2+ primarily mobilized for signaling that must be replenished to sustain signaling and restore Ca2+ homeostasis.

    “It is known that in eukaryotes the ER constitutes a finite reservoir of Ca 2ϩ primarily mobilized for signaling that must be replenished to sustain the duration of signaling and ultimately restore Ca 2ϩ homeostasis in the ER and the cytosol (1-3, 32).”

    From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [32]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Brostrom, M. A., & Brostrom, C. O.
Corresponding author
Brostrom, Margaret A
Venue
Cell Calcium
Publisher
Elsevier BV
Published
2003-10
Volume
34
Issue
4-5
Pages
345-363
ISSN
0143-4160 (ISSN-L)
DOI
10.1016/s0143-4160(03)00127-1
OpenAlex
W2038563918
Cited by
197
References
124
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 5 · 2017: 16 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 12 · 2012: 13
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cell Calcium (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
endoplasmic reticulum calcium, ER calcium stores, unfolded protein response, endoplasmic reticulum stress, protein synthesis regulation, translational regulation, GRP78, ER chaperones, cytosolic free calcium, protein misfolding, embryonic cardiomyocytes, cell growth, ATP metabolism, mRNA translation regulation
MeSH terms
Endoplasmic Reticulum Chaperone BiP, Adenosine Triphosphate, Animals, Calcium, Carrier Proteins, Cell Division, Endoplasmic Reticulum, Gene Expression Regulation, Heat-Shock Proteins, Hormones, Humans, Hypertrophy, Models, Biological, Protein Processing, Post-Translational, Sarcoplasmic Reticulum, Protein Biosynthesis, Vasopressins, Eukaryotic Initiation Factor-2, Molecular Chaperones, Calcium Signaling, Myocytes, Cardiac

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review