The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
Abstract
The CD28 molecule, a disulfide-linked homodimer expressed on peripheral T cells and thymocytes, mediates an essential costimulatory signal following engagement of the T cell receptor (TCR). Increased proportions of CD28- T cells have been observed during aging and in situations of chronic immune stimulation, but the origin and functional characteristics of these cells have been unclear. T cells which reach replicative senescence in culture after multiple rounds of cell division have shortened telomeres, respond poorly to stress stimuli, and no longer express CD28, suggesting that CD28- T cells observed in vivo may be the progeny of memory cells which have been repeatedly stimulated. This review describes the features of T cell replicative senescence, presents several possible mechanisms for the generation of senescent T cells in vivo, and proposes that replicative senescence may explain immune exhaustion.
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“These oligoclonal expanded CD8 + memory T cells are further distinguished in humans by loss of expression of the CD28 co-stimulatory molecule (47,48) and impaired immune function.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [47]
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Cites
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Self-citationReplicative Senescence: Implications for in Vivo Aging and Tumor Suppression
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The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793
CD28 extinction in human T cells: altered functions and the program of T‐cell senescence
Vallejo, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00256.x · Cited by 446
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421
Telomere shortening in T cells correlates with Alzheimer's disease status
Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 411
Metadata
- Authors
- Effros, R. B.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Effros, Rita B.
- ORCID
- Effros, Rita B.
- Venue
- Developmental & Comparative Immunology
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 21
- Issue
- 6
- Pages
- 471-478
- ISSN
- 0145-305X (ISSN-L)
- OpenAlex
- W2032253593
- Cited by
- 175
- References
- 33
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 2 · 2016: 4 · 2015: 10 · 2014: 3 · 2013: 9 · 2012: 5
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental & Comparative Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-10415, P60AG010415)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- CD28, immunosenescence, immune exhaustion, T cell costimulation, telomere shortening, memory T cells, chronic immune stimulation, T cell receptor signaling
- MeSH terms
- Cell Division, Humans, T-Lymphocytes, Biomarkers, Telomere, Cellular Senescence, CD28 Antigens
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