The DOI matches its Crossref record; 83 of the 89 references it cites were found in a registry or an index.
Receptor subtype-specific dopaminergic agents and conditioned behavior
Abstract
Dopaminergic neurotransmission has been implicated in reward-related learning. With the advent of pharmacological agents that are relatively specific for D1 and D2 dopamine receptors, it has become possible to assess the role of these receptor subtypes in this form of learning. Antagonist studies have shown that either D1 or D2 receptor blockers produced extinction-like effects on operant responding for food, water or brain stimulation reward and in drug self-administration paradigms. They also blocked place preference learning based on amphetamine. Agonist studies showed that D2, but not D1 agonists were self-administered, produced place preferences and enhanced responding for conditioned reward. It may be that the dopaminergic signal at the D1 receptor is important for the establishment and maintenance of reward-related learning. From this point of view the effects of D1 antagonists can be understood. D2 antagonists may produce extinction-like effects because they lead to increased dopamine release and, therefore, indirectly mask the dopamine signal at the D1 receptor. D1 agonists may fail to produce reward effects because they, unlike D2 agonists, directly mask the dopaminergic signal at the D1 receptor.
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“Selective activation of D1R also disrupts several kinds of reward and incentive learning (Beninger et al 1989) and therefore may disrupt the learning of associations between the social reward provided by the partner, and the partner’s specific identity cues.”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Beninger et al 1989
In the citing paper
“Meanwhile, activation of D2R in the NAC shell is rewarding and enhances reward-based learning (Beninger et al 1989), which aligns well with the role of D2R in pair bonding.”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Beninger et al 1989
Citations
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Cited by
Sorted by citations
Dopamine receptors: from structure to function
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Metadata
- Authors
- Beninger, R. J., Hoffman, D. C., & Mazurski, E. J.
- Affiliations
- Queen's University (CA)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 1989-06
- Volume
- 13
- Issue
- 2-3
- Pages
- 113-122
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1976403478
- Cited by
- 109
- References
- 89
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 7
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, reward learning, conditioned reward, self-administration, extinction, place preference, amphetamine, dopamine release
- MeSH terms
- Animals, Avoidance Learning, Conditioning, Psychological, Receptors, Dopamine, Reward, Self Administration, Dopamine Agents, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Antagonists
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