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Cited by 689Neuroendocrine regulation and behaviorAttachment and Relationship DynamicsHuman-Animal Interaction Studies

The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.

Brain substrates of infant-mother attachment: contributions of opioids, oxytocin, and norepinephrine.

Nelson, Eric E, Panksepp, Jaak·1998·Neuroscience & Biobehavioral Reviews
DOI 10.1016/s0149-7634(97)00052-3
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Abstract

The aim of this paper is to review recent work concerning the psychobiological substrates of social bonding, focusing on the literature attributed to opioids, oxytocin and norepinephrine in rats. Existing evidence and thinking about the biological foundations of attachment in young mammalian species and the neurobiology of several other affiliative behaviors including maternal behavior, sexual behavior and social memory is reviewed. We postulate the existence of social motivation circuitry which is common to all mammals and consistent across development. Oxytocin, vasopressin, endogenous opioids and catecholamines appear to participate in a wide variety of affiliative behaviors and are likely to be important components in this circuitry. It is proposed that these same neurochemical and neuroanatomical patterns will emerge as key substrates in the neurobiology of infant attachments to their caregivers.

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Crossref · 10.1016/s0149-7634(97)00052-3

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Research works printed but not linked: 21

  1. J.R. Alberts, Ontogeny of social recognition: An essay on mechanism and metaphor in behavioral development, in: E.S Goulin (Ed.), Comparative Development of Adaptive Skills: Evolutionary Implications, Erlbaum, Hillsdale, NJ, 1985, pp. 65–101.
  2. K.E. Barnard, T.B. Brazelton, Touch: The Foundation of Experience, International Univ. Press, Madison, CT, 1990.
  3. M.L. Bauman, T.L. Kemper, (Eds.), The Neurobiology of Autism, Johns Hopkins Univ. Press, Baltimore, 1994.
  4. G.D. Carr, H.C. Fibriger, A.G. Phillips, Conditioned place preference as a measure of drug reward, in: J.M. Liebman, S.M. Cooper (Eds.), The Neuropharmacological Basis of Reward, Clarendon Press, Oxford, 1988, pp. 264–319.
  5. T.M. Field, The therapeutic effect of touch, in: G. Branningan, M. Merrens (Eds.), The Undaunted Psychologists: Adventures in Research, McGraw Hill, New York, 1993.
  6. C. Gillberg, M. Coleman, The Biology of the Autistic Syndromes, 2nd ed. MacKeith Press, Oxford, 1992.
  7. B.H. Herman, Effects of opioid receptor antagonists in the treatment of autism and self-injurious behavior, in: J.J. Ratsey (Ed.), Progress in Psychiatry, No. 32, Mental Retardations: Developing Pharmacotherapies, American Psychiatric Press, Washington, DC, 1991, pp. 107–137.
  8. N.A. Krasnegor, R.S Bridges (Eds.), Mammalian Parenting, Oxford University Press, Oxford, 1990.
  9. W.A. Mason, Motivational factors in psychosocial development, in: W.J. Arnold, N.M. Page (Eds.), Nebraska Symposium on Motiavtion, vol. 18, University of Nebraska Press, Lincoln, 1970, pp. 35–68.
  10. McCann, 1989, LiCl CCK inhibit gastric emptying and stimulate OT secretion in rats, Am. J. Physiol., 256, R463
  11. Nelson, 1995, Social behavior in the young, vasopressin deficient Brattleboro rat, Soc. Neurosci. Abstr., 20, 366
  12. N. Newton, The role of oxytocin in three interpersonal acts: coitus, birth and breastfeeding, in: L. Carenza, P. Pancheri, L. Zichella (Eds.), Clinical Psychoneuroendocrinology in Reproduction, Academic, New York, 1978, pp. 411–418.
  13. J. Panksepp, Brain opioids: A neurochemical substrate for narcotic and social dependence, in: S. Cooper (Ed.), Progress in Theory in Psychopharmacology, Academic, London, 1981, pp. 149–175.
  14. Panksepp, 1988, Posterior pituitary hormones and separation distress in chicks, Soc. Neurosci. Abstr., 14, 287
  15. J. Panksepp, The psychoneurology of fear: evolutionary perspectives and the role of animal models in understanding human anxiety, in: R. Burrows (Ed.), Handbook of Anxiety, Elsevier/North-Holland Biomedical, Amsterdam, 1990, pp. 41–57.
  16. J. Panksepp, Affective Neuroscience: a conceptual framework for the neurobiological study of emotions, in: K. Strongman (Ed.), International Reviews of Emotion Research, vol. 1, Wiley, Chichester, 1991, pp. 59–99.
  17. Panksepp, 1995, Prolactin reduces separation-distress in young domestic chicks, Soc. Neurosci. Abstr., 20, 811
  18. Panksepp, 1989, Delta and kappa opiate receptor control of separation distress, Soc. Neurosci. Abstr., 15, 845
  19. J.P. Scott, Effects of psychotropic drugs on separation distress in dogs, Proc. IX CINP, Exerpta Medica International Congress Series No. 359, 1974, pp. 735–745.
  20. J.P. Scott (Ed.), Critical Periods, Dowden, Hutchinson & Ross, New York, 1978.
  21. Young, 1996, Maternal behavior and brain oxytocin receptors unaffected in oxytocin knockout mice, Soc. Neurosci. Abstr., 22, 2070

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Metadata

Authors
Nelson, E. E., & Panksepp, J.
Affiliations
  • Indiana University Bloomington (US)
  • Bowling Green State University (US)
Corresponding author
Nelson, Eric E
ORCID
Nelson, Eric E
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1998-05
Volume
22
Issue
3
Pages
437-452
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/s0149-7634(97)00052-3
OpenAlex
W1981657115
Cited by
688
References
207
Citations by year
2026: 9 · 2025: 12 · 2024: 20 · 2023: 38 · 2022: 18 · 2021: 29 · 2020: 15 · 2019: 29 · 2018: 32 · 2017: 29 · 2016: 45 · 2015: 29 · 2014: 31 · 2013: 47 · 2012: 29
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
Keywords
infant-mother attachment, social bonding, oxytocin, endogenous opioids, norepinephrine, vasopressin, catecholamines, maternal behavior, affiliative behavior, social memory, sexual behavior, neurobiology of attachment, rats
MeSH terms
Animals, Brain, Brain Chemistry, Humans, Mother-Child Relations, Norepinephrine, Oxytocin, Opioid Peptides, Rats

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