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Cited by 160Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesExercise and Physiological Responses

Oxygen Free Radicals and Antioxidants: A Review

Barber, Dustan A., Harris, Steven R.·1994·American Pharmacy
DOI 10.1016/s0160-3450(15)30310-x
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Abstract

In 1989, nearly 43% of deaths in the United States were due to some form of cardiovascular disease, and 23% were caused by cancer. Thus, two of every three people in this country die from either cardiovascular disease or cancer. Based on both experimental and epidemiological evidence, investigators believe that free radicals play a critical role in the development of both diseases. Low levels of antioxidants, which increases free radical activity, are clearly associated with an increased risk of these diseases. This link has led to the conclusion that use of antioxidant vitamin supplements to scavenge free radicals could potentially decrease the risks of cancer and cardiovascular disease. Results from numerous studies to date have been very promising, although a true protective or preventive causal relationship has not yet been established. Numerous primary and secondary intervention trials currently underway should more definitively assess the role of antioxidants in disease prevention. In the interim, many people feel the evidence is now strong enough to begin supplementation on their own. The pharmacist is in a position to advise patients on the safe and moderate use of antioxidants. The antioxidants discussed in this article are relatively non-toxic, with the exception of vitamin A. The possible benefits of vitamin A are better achieved with the use of beta-carotene. Megadose antioxidant supplementation does not appear to provide any additional benefit beyond what a more moderate supplement can provide and should therefore be discouraged. Taking a trace mineral with antioxidant potential is generally a waste of money, provided the patient is not initially deficient in the element.(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1016/s0160-3450(15)30310-x

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  • The relationship between coffee consumption, antioxidant activity, and brewing methods is largely uncharacterized.

    “The role of antioxidant compounds as radical-scavengers in the body is well-researched24–26, but the relationship between coffee consumption, antioxidant activity, and brewing methods is largely uncharacterized.”

    From Acidity and Antioxidant Activity of Cold Brew Coffee (2018) · cites this paper as [24]

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Authors
Barber, D. A., & Harris, S. R.
Affiliations
  • Mayo Clinic (US)
  • University of Georgia (US)
ORCID
Harris, Steven R.
Venue
American Pharmacy
Publisher
Elsevier BV
Published
1994-09
Volume
34
Issue
9
Pages
26-35
ISSN
0160-3450 (ISSN-L)
DOI
10.1016/s0160-3450(15)30310-x
OpenAlex
W955891050
Cited by
160
References
78
Citations by year
2025: 7 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 10
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Pharmacy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
oxygen free radicals, antioxidants, cardiovascular disease, cancer prevention, free radical scavenging, vitamin A toxicity, beta-carotene, trace elements, pharmacist counseling, oxidative stress
MeSH terms
Antioxidants, Arthritis, Rheumatoid, Cardiovascular Diseases, Carotenoids, Free Radicals, Humans, Neoplasms, Oxygen, Superoxides, Vitamin A, Vitamin E, beta Carotene

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