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Cited by 49Ginkgo biloba and Cashew ApplicationsAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress

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Droy-Lefaix, M. T.·1997·AGE
DOI 10.1007/s11357-997-0013-1PMC PMC3455891
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Abstract

Aging is responsible for oxidative damage to DNA, protein, lipid, and other macromolecules linked to tissue alterations. The resultant damage contributes significantly to degenerative diseases, to include those of the brain, sensorial tissues, and cardiovascular system. To protect cellular components from oxyradical attack, especially lipoperoxidation, a substantial interest in the use of antioxidants has evolved. A free radical scavenger, Ginkgo biloba extract (EGb 761) may be effective in fighting the oxidative stress related to aging. Many data support the efficacy of EGb 761 in biological model systems. In aging processes, EGb 761 may ameliorate the mitochondria respiratory chain function by quenching the superoxide anion, and the hydroxyl and peroxyl radicals. It protects the brain by facilitating the uptake of neurotransmitters and by reducing ischemia-reperfusion episodes and level of apoptosis. Moreover, in sensorial tissues, EGb 761 reduces apoptosis in the olfactive bulb and in the retinal pigmented epithelium of the eye, and protects against the lipoperoxidation alteration of the retina that results in a decrease of the electroretinogram response. In the cardiovascular system, by a direct effect on oxidative low density lipoproteins, EGb 761 may decrease atherosclerosis evolution, and is shown to accelerate cardiac mechanical recovery after ischemia-reperfusion. In conclusion, the antioxidant effects of EGb 761 noted in many experimental data, may explain the therapeutic efficacy observed in clinical trials of the elderly. These beneficial properties seem in part to come from the activity of EGb 761 constituents, such as flavonoids and terpens.

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  • Numerous natural bioactive compounds have demonstrated neuroprotective roles via antioxidation, antineuroinflammation, anti-amyloid-beta and tau aggregation, and targeting cholinergic neurotransmission.

    “Numerous natural bioactive compounds have been demonstrated to have neuroprotective roles via antioxidation, antineuroinflammatory, anti- Aβ and tau aggregation, as well as targeting cholinergic neurotransmission [44,45,46].”

    From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [44]

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Authors
Droy-Lefaix, M. T.
Affiliations
Ipsen (France) (FR)
Corresponding author
Droy-Lefaix, M. T.
Venue
AGE
Publisher
Springer Science and Business Media LLC
Published
1997-07
Volume
20
Issue
3
Pages
141-149
ISSN
  • 0161-9152 (ISSN-L)
  • 1574-4647
DOI
10.1007/s11357-997-0013-1
PMC
PMC3455891
OpenAlex
W2068613374
Cited by
49
References
63
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1
FWCI
5.47
Type
journal article
Language
en
Open access
Licence
Locations
  • AGE (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
Ginkgo biloba extract EGb 761, antioxidant activity, aging, oxidative stress, free radical scavenging, lipid peroxidation, superoxide, mitochondrial respiratory chain, cerebral protection, ischemia-reperfusion, apoptosis, olfactory bulb, retinal pigment epithelium, electroretinogram, atherosclerosis, LDL oxidation, flavonoids, terpenes

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