The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins
Abstract
Nitric oxide is unique among the higher oxides of nitrogen in its reactivity and efficiency for the oxidation of oxygen-bound hemoproteins. Dinitrogen trioxide serves as a nitric oxide donor, but dinitrogen tetroxide does not exhibit similar reactivity. Details are provided of the stoichiometric transformation through which nitric oxide is converted to nitrate with accompanying oxidation of myoglobin or hemoglobin to the corresponding iron(III) hemoprotein, including an estimate of the rate constant for nitric oxide oxidation of oxygen-associated myoglobin and the effect of unassociated oxygen on the stoichiometry and rates for nitric oxide oxidation. Evidence is presented to establish the mechanism of oxidation in the direct combination of nitric oxide with iron(II)-bound dioxygen.
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“The biggest conceptual challenge to the notion that deoxyHb plays a major role in bioactivation of nitrite is that NO produced in the red blood cell would be rapidly scavenged by the dioxygenation reaction where NO reacts with oxygenated Hb (OxyHb) to form MetHb and nitrate,”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [42]
Citations
Cites
Cooperativity in the dissociation of nitric oxide from hemoglobin.
Moore, E. G., & Gibson, Q. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33557-3 · Cited by 292
Conformation, co-operativity and ligand binding in human hemoglobin
Cassoly, R., & Gibson, Q. H. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90382-4 · Cited by 259
Inorganic oxygen carriers as models for biological systems
McLendon, G. L., & Martell, A. E. (1976) · Coordination Chemistry Reviews · doi:10.1016/s0010-8545(00)80403-8 · Cited by 225
Absorption spectra and reaction kinetics of NO2, N2O3, and N2O4 in aqueous solution
Treinin, A., & Hayon, E. (1970) · Journal of the American Chemical Society · doi:10.1021/ja00723a001 · Cited by 221
Grätzel, M., Henglein, A., & Taniguchi, S. (1970) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19700740322 · Cited by 189
Interaction of Nitrous Acid with Hydrogen Peroxide and with Water
Anbar, M., & Taube, H. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01653a007 · Cited by 179
Pulsradiolytische Untersuchung einiger Elementarprozesse der Oxydation und Reduktion des Nitritions
Grätzel, M., Henglein, A., Lilie, J., & Beck, G. (1969) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19690730707 · Cited by 166
Austin, J. H., & Drabkin, D. L. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74966-1 · Cited by 156
The higher oxides of nitrogen: Inhalation toxicology
Guidotti, T. L. (1978) · Environmental Research · doi:10.1016/0013-9351(78)90125-1 · Cited by 138
Wallace, W. J., Maxwell, J. C., & Caughey, W. S. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90810-9 · Cited by 120
Research works printed but not linked: 3
- Azoulay, 1978, Toxicol. Europ. Res., 1, 7
- Ehrman, 1972, Am. Indust. Hygiene Assoc. J., 751
- Challis, 1979, J. C. S., Perkin Trans. I, 299
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Metadata
- Authors
- Doyle, M. P., & Hoekstra, J. W.
- Affiliations
- Hope College (US)
- Corresponding author
- Doyle, Michael P.
- ORCID
- Doyle, Michael P.
- Venue
- Journal of Inorganic Biochemistry
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 14
- Issue
- 4
- Pages
- 351-358
- ISSN
- 0162-0134 (ISSN-L)
- OpenAlex
- W2019435702
- Cited by
- 643
- References
- 24
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 12 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 19 · 2017: 12 · 2016: 7 · 2015: 17 · 2014: 13 · 2013: 26 · 2012: 15
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Inorganic Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- NO oxidation, heme proteins, myoglobin, hemoglobin, dinitrogen trioxide, dinitrogen tetroxide, nitrate formation, reaction mechanism, rate constants
- MeSH terms
- Animals, Hemoglobin A, Horses, Humans, Kinetics, Myocardium, Myoglobin, Nitric Oxide, Nitrogen Oxides, Oxidation-Reduction, Oxyhemoglobins
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