Cited by 643Hemoglobin structure and functionMetal-Catalyzed Oxygenation MechanismsNitric Oxide and Endothelin Effects

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Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins

Doyle, Michael P., Hoekstra, James W.·1981·Journal of Inorganic Biochemistry

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Abstract

Nitric oxide is unique among the higher oxides of nitrogen in its reactivity and efficiency for the oxidation of oxygen-bound hemoproteins. Dinitrogen trioxide serves as a nitric oxide donor, but dinitrogen tetroxide does not exhibit similar reactivity. Details are provided of the stoichiometric transformation through which nitric oxide is converted to nitrate with accompanying oxidation of myoglobin or hemoglobin to the corresponding iron(III) hemoprotein, including an estimate of the rate constant for nitric oxide oxidation of oxygen-associated myoglobin and the effect of unassociated oxygen on the stoichiometry and rates for nitric oxide oxidation. Evidence is presented to establish the mechanism of oxidation in the direct combination of nitric oxide with iron(II)-bound dioxygen.

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Cooperativity in the dissociation of nitric oxide from hemoglobin.
Moore, E. G., & Gibson, Q. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33557-3 · Cited by 292
Conformation, co-operativity and ligand binding in human hemoglobin
Cassoly, R., & Gibson, Q. H. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90382-4 · Cited by 259
Inorganic oxygen carriers as models for biological systems
McLendon, G. L., & Martell, A. E. (1976) · Coordination Chemistry Reviews · doi:10.1016/s0010-8545(00)80403-8 · Cited by 225
Absorption spectra and reaction kinetics of NO2, N2O3, and N2O4 in aqueous solution
Treinin, A., & Hayon, E. (1970) · Journal of the American Chemical Society · doi:10.1021/ja00723a001 · Cited by 221
Pulsradiolytische Beobachtungen über die Reduktion des NO3−‐Ions und über Bildung und Zerfall der persalpetrigen Säure in wäßriger Lösung
Grätzel, M., Henglein, A., & Taniguchi, S. (1970) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19700740322 · Cited by 189
Interaction of Nitrous Acid with Hydrogen Peroxide and with Water
Anbar, M., & Taube, H. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01653a007 · Cited by 179
Pulsradiolytische Untersuchung einiger Elementarprozesse der Oxydation und Reduktion des Nitritions
Grätzel, M., Henglein, A., Lilie, J., & Beck, G. (1969) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19690730707 · Cited by 166
SPECTROPHOTOMETRIC STUDIES
Austin, J. H., & Drabkin, D. L. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74966-1 · Cited by 156
The higher oxides of nitrogen: Inhalation toxicology
Guidotti, T. L. (1978) · Environmental Research · doi:10.1016/0013-9351(78)90125-1 · Cited by 138
The mechanisms of hemoglobin autoxidation evidence for proton-assisted nucleophilic displacement of superoxide by anions
Wallace, W. J., Maxwell, J. C., & Caughey, W. S. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90810-9 · Cited by 120

Show all 24 references

Research works printed but not linked: 3

Azoulay, 1978, Toxicol. Europ. Res., 1, 7
Ehrman, 1972, Am. Indust. Hygiene Assoc. J., 751
Challis, 1979, J. C. S., Perkin Trans. I, 299

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Self-citation
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Giulivi, C. (1998) · Biochemical Journal · doi:10.1042/bj3320673 · Cited by 213
Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules
Eiserich, J. P., Patel, R. P., & O’Donnell, V. B. (1998) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(99)00002-3 · Cited by 211
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Determination of lung capillary blood volume and membrane diffusing capacity in man by the measurements of NO and CO transfer
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Nitric oxide and quality and safety of muscle based foods
Skibsted, L. H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.03.307 · Cited by 201
Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb.
Roberts, J. D., Chen, T. Y., Kawai, N., Wain, J. R., Dupuy, P., Shimouchi, A., Bloch, K. D., Polaner, D. M., & Zapol, W. M. (1993) · Circulation Research · doi:10.1161/01.res.72.2.246 · Cited by 199
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Möller, M. N., Ríos, N., Trujillo, M., Radí, R., Denicola, A., & Álvarez, B. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.006136 · Cited by 200
The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase
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Self-citation
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Abu‐Soud, H. M., Wang, J., Rousseau, D. L., Fukuto, J. M., Ignarro, L. J., & Stuehr, D. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.22997 · Cited by 193
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Azarov, I., Huang, K. T., Basu, S., Gladwin, M. T., Hogg, N., & Kim‐Shapiro, D. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509045200 · Cited by 191
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Rivoal, J., Hill, R. D., Dordas, C. A., & Hasinoff, B. B. (2004) · Planta · doi:10.1007/s00425-004-1212-y · Cited by 186
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Wink, D. A., Grisham, M. B., Mitchell, J. B., & Ford, P. C. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68006-9 · Cited by 182
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Brunori, M., & Gibson, Q. H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve159 · Cited by 177
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Lai, C., & Komarov, A. M. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00422-6 · Cited by 175
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Sexton, D. J., Muruganandam, A., McKenney, D. J., & Mutus, B. (1994) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1994.tb05065.x · Cited by 174
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Mordvintcev, P. I., Mülsch, A., Busse, R., & Vanin, A. F. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90282-x · Cited by 174
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Chiurchiù, V., & Maccarrone, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3547 · Cited by 175

Authors: Doyle, M. P., & Hoekstra, J. W.
Affiliations: Hope College (US)
Corresponding author: Doyle, Michael P.
ORCID: Doyle, Michael P.
Venue: Journal of Inorganic Biochemistry
Publisher: Elsevier BV
Published: 1981-01
Volume: 14
Issue: 4
Pages: 351-358
ISSN: 0162-0134 (ISSN-L)
DOI: 10.1016/s0162-0134(00)80291-3
OpenAlex: W2019435702
Cited by: 643
References: 24
Citations by year: 2026: 1 · 2025: 11 · 2024: 12 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 19 · 2017: 12 · 2016: 7 · 2015: 17 · 2014: 13 · 2013: 26 · 2012: 15
FWCI: 1.05
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Inorganic Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: NO oxidation, heme proteins, myoglobin, hemoglobin, dinitrogen trioxide, dinitrogen tetroxide, nitrate formation, reaction mechanism, rate constants
MeSH terms: Animals, Hemoglobin A, Horses, Humans, Kinetics, Myocardium, Myoglobin, Nitric Oxide, Nitrogen Oxides, Oxidation-Reduction, Oxyhemoglobins

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Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins

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