The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins
Abstract
Nitric oxide is unique among the higher oxides of nitrogen in its reactivity and efficiency for the oxidation of oxygen-bound hemoproteins. Dinitrogen trioxide serves as a nitric oxide donor, but dinitrogen tetroxide does not exhibit similar reactivity. Details are provided of the stoichiometric transformation through which nitric oxide is converted to nitrate with accompanying oxidation of myoglobin or hemoglobin to the corresponding iron(III) hemoprotein, including an estimate of the rate constant for nitric oxide oxidation of oxygen-associated myoglobin and the effect of unassociated oxygen on the stoichiometry and rates for nitric oxide oxidation. Evidence is presented to establish the mechanism of oxidation in the direct combination of nitric oxide with iron(II)-bound dioxygen.
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“The biggest conceptual challenge to the notion that deoxyHb plays a major role in bioactivation of nitrite is that NO produced in the red blood cell would be rapidly scavenged by the dioxygenation reaction where NO reacts with oxygenated Hb (OxyHb) to form MetHb and nitrate,”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [42]
Citations
Cites
Cooperativity in the dissociation of nitric oxide from hemoglobin.
Moore, E. G., & Gibson, Q. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33557-3 · Cited by 292
Conformation, co-operativity and ligand binding in human hemoglobin
Cassoly, R., & Gibson, Q. H. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90382-4 · Cited by 259
Inorganic oxygen carriers as models for biological systems
McLendon, G. L., & Martell, A. E. (1976) · Coordination Chemistry Reviews · doi:10.1016/s0010-8545(00)80403-8 · Cited by 225
Absorption spectra and reaction kinetics of NO2, N2O3, and N2O4 in aqueous solution
Treinin, A., & Hayon, E. (1970) · Journal of the American Chemical Society · doi:10.1021/ja00723a001 · Cited by 221
Grätzel, M., Henglein, A., & Taniguchi, S. (1970) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19700740322 · Cited by 189
Interaction of Nitrous Acid with Hydrogen Peroxide and with Water
Anbar, M., & Taube, H. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01653a007 · Cited by 179
Pulsradiolytische Untersuchung einiger Elementarprozesse der Oxydation und Reduktion des Nitritions
Grätzel, M., Henglein, A., Lilie, J., & Beck, G. (1969) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19690730707 · Cited by 166
Austin, J. H., & Drabkin, D. L. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74966-1 · Cited by 156
The higher oxides of nitrogen: Inhalation toxicology
Guidotti, T. L. (1978) · Environmental Research · doi:10.1016/0013-9351(78)90125-1 · Cited by 138
Wallace, W. J., Maxwell, J. C., & Caughey, W. S. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90810-9 · Cited by 120
Wallace, W. J., & Caughey, W. S. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(75)90435-0 · Cited by 118
Nitrosyl-Hemoglobin Formation in the Blood of Animals Exposed to Nitric Oxide
Oda, H., Kusumoto, S., & Nakajima, T. (1975) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1975.10666749 · Cited by 104
Properties of the T state of human oxyhemoglobin studies by laser photolysis.
Sawicki, C. A., & Gibson, Q. H. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41001-5 · Cited by 102
A Structural Model for the Kinetic Behavior of Hemoglobin
Moffat, K., Deatherage, J. F., & Seybert, D. W. (1979) · Science · doi:10.1126/science.493990 · Cited by 96
Effect of exposure to 43 ppm nitric oxide and 3.6 ppm nitrogen dioxide on rabbit lung
Hugod, C. (1979) · International Archives of Occupational and Environmental Health · doi:10.1007/bf00377770 · Cited by 86
A mechanism for the conversion of oxyhemoglobin to methemoglobin by nitrite.
Fl, R. (1976) · Clinical Chemistry · doi:10.1093/clinchem/22.12.1986 · Cited by 78
Gerritse, R. G. (1979) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)95352-x · Cited by 52
Infrared Absorption by Peroxy-Nitrogen Trioxide Free Radical in the Gas Phase
Guillory, W. A., & Johnston, H. S. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1696316 · Cited by 43
Effect of nitric oxide on the oxygen transport of human erythrocytes
Kon, K., Maeda, N., & Shiga, T. (1977) · Journal of Toxicology and Environmental Health · doi:10.1080/15287397709529508 · Cited by 35
Reaction of Nitrogen Dioxide With Blood and Lung Components
Rowlands, J. R. (1971) · Archives of Internal Medicine · doi:10.1001/archinte.1971.00310190098012 · Cited by 22
Identification of Nitric Oxide (NO) in Human Blood
Freeman, G., Dyer, R. L., Juhos, L. T., JOHN, G. A. S., & Anbar, M. (1978) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1978.10667303 · Cited by 21
Ray, J. D. (1962) · Journal of Inorganic and Nuclear Chemistry · doi:10.1016/0022-1902(62)80262-0 · Cited by 20
Kinetics of the Nitrogen Dioxide Catalyzed Oxidation of Nitric Oxide
Ray, J. D., & Ogg, R. A. (1957) · The Journal of Chemical Physics · doi:10.1063/1.1743543 · Cited by 11
Reaction of nitrogen dioxide with blood and lung components. Electron spin resonance studies
Rowlands, J. R. (1971) · Archives of Internal Medicine · doi:10.1001/archinte.128.1.94 · Cited by 9
Research works printed but not linked: 3
- Azoulay, 1978, Toxicol. Europ. Res., 1, 7
- Ehrman, 1972, Am. Indust. Hygiene Assoc. J., 751
- Challis, 1979, J. C. S., Perkin Trans. I, 299
Cited by
Sorted by citations
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
A Rapid, Simple Spectrophotometric Method for Simultaneous Detection of Nitrate and Nitrite
Miranda, K. M., Espey, M. G., & Wink, D. A. (2001) · Nitric Oxide · doi:10.1006/niox.2000.0319 · Cited by 3,858
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Nitric oxide donors: chemical activities and biological applications
Wang, P. G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., & Janczuk, A. J. (2002) · Chemical Reviews · doi:10.1021/cr000040l · Cited by 1,337
Metadata
- Authors
- Doyle, M. P., & Hoekstra, J. W.
- Affiliations
- Hope College (US)
- Corresponding author
- Doyle, Michael P.
- ORCID
- Doyle, Michael P.
- Venue
- Journal of Inorganic Biochemistry
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 14
- Issue
- 4
- Pages
- 351-358
- ISSN
- 0162-0134 (ISSN-L)
- OpenAlex
- W2019435702
- Cited by
- 643
- References
- 24
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 12 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 14 · 2018: 19 · 2017: 12 · 2016: 7 · 2015: 17 · 2014: 13 · 2013: 26 · 2012: 15
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Inorganic Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- NO oxidation, heme proteins, myoglobin, hemoglobin, dinitrogen trioxide, dinitrogen tetroxide, nitrate formation, reaction mechanism, rate constants
- MeSH terms
- Animals, Hemoglobin A, Horses, Humans, Kinetics, Myocardium, Myoglobin, Nitric Oxide, Nitrogen Oxides, Oxidation-Reduction, Oxyhemoglobins
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