Cited by 217Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsHerpesvirus Infections and Treatments

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Activity of Porphyridium sp. polysaccharide against herpes simplex viruses in vitro and in vivo

Huheihel, Mahmoud, Ishanu, Vladimir, Tal, Jacov, Arad, Shoshana (Malis)·2002·Journal of Biochemical and Biophysical Methods

DOI 10.1016/s0165-022x(01)00186-5

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Abstract

The cell wall sulfated polysaccharide of the red microalga Porphyridium sp. exhibited impressive antiviral activity against herpes simplex virus types 1 and 2 (HSV-1 and -2) both in vitro (cell culture) and in vivo (rats and rabbits). Depending on the concentration, this polysaccharide completely inhibited or slowed down the development of the cytopathic effect in HSV-infected cells, but did not show any cytotoxic effects on vero cells even when a concentration as high as 250 microg/ml was used. There was indirect evidence for a strong interaction between the polysaccharide and HSV and a weak interaction with the cell surface. When tested in vivo, Porphyridium sp. polysaccharide conferred significant and efficient protection against HSV-1 infection: at a concentration as low as 100 microg/ml, it prevented the appearance and development of symptoms of HSV-1 infection in rats and rabbits. The polysaccharide did not exhibit any cytotoxic effects at a concentration of 2 mg/ml in vivo.

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Authors: Huheihel, M., Ishanu, V., Tal, J., & Arad, S. (.
Affiliations: Ben-Gurion University of the Negev (IL)
Corresponding author: Huheihel, Mahmoud
ORCID: Arad, Shoshana (Malis)
Venue: Journal of Biochemical and Biophysical Methods
Publisher: Elsevier BV
Published: 2002-01
Volume: 50
Issue: 2-3
Pages: 189-200
ISSN: 0165-022X (ISSN-L)
DOI: 10.1016/s0165-022x(01)00186-5
OpenAlex: W1986624355
Cited by: 217
References: 24
Citations by year: 2026: 7 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 15 · 2021: 17 · 2020: 24 · 2019: 13 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 12
FWCI: 5.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Biochemical and Biophysical Methods (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Keywords: Porphyridium, sulfated polysaccharides, cell wall polysaccharides, antiviral activity, herpes simplex virus type 1, herpes simplex virus type 2, red microalgae, cytopathic effect inhibition, cytotoxicity, cell surface binding
MeSH terms: Adsorption, Rhodophyta, Animals, Chlorocebus aethiops, Cytopathogenic Effect, Viral, Herpes Simplex, Male, Polysaccharides, Rabbits, Vero Cells, Keratitis, Herpetic, Herpesvirus 2, Human, Herpesvirus 1, Human, Rats, In Vitro Techniques

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Activity of Porphyridium sp. polysaccharide against herpes simplex viruses in vitro and in vivo

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