The methodology and scope of human microneurography
Abstract
Microneurography was introduced in 1967 and has developed into an invaluable tool for investigating human somatosensory, motor and cardiovascular physiology and pathophysiology. It involves percutaneous insertion of a metal microelectrode into fascicles of limb and facial nerves. This review covers the procedures and equipment necessary for microneurography and provides a current circuit for a preamplifier. Evidence is presented that (i) most recordings from myelinated axons involve an effective penetration of the myelin by the electrode; (ii) based on physiological criteria, microstimulation through the electrode can be used to activate single axons although the probability of this is relatively low and (iii) despite 'micro' lesions caused by the electrode insertion into the nerve and its fascicles, the morbidity with the procedure is acceptably low.
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Despite microlesions caused by electrode insertion into the nerve, the morbidity of microneurography is acceptably low.
“Despite the production of microlesions caused by the electrode insertion into the nerve, the morbidity with the procedure is acceptably low (Gandevia and Hales, 1997) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Gandevia and Hales, 1997
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- Authors
- Gandevia, S. C., & Hales, J. P.
- Affiliations
- Neuroscience Research Australia (AU)
- Corresponding author
- Gandevia, S.C
- ORCID
- Gandevia, S.C
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 74
- Issue
- 2
- Pages
- 123-136
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2020072769
- Cited by
- 39
- References
- 7
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- nerve fascicles, myelinated axons, microstimulation, preamplifier circuit, motor physiology, cardiovascular physiology
- MeSH terms
- Action Potentials, Amplifiers, Electronic, Humans, Microelectrodes, Nerve Fibers, Neurons
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