The DOI matches its Crossref record; 41 of the 43 references it cites were found in a registry or an index.
Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety
Abstract
According to "The Neuropsychology of Anxiety" [Gray, J.A., 1982, The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, Oxford; Gray, J.A., McNaughton, N., 2000, The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, 2nd ed., Oxford University Press, Oxford], anxiolytic drugs of all types act on a behavioural inhibition system, the most important neural component of which is the septo-hippocampal system. Anxiolytics affect septo-hippocampal function by impairing the subcortical control of hippocampal "theta" activity - the principle response of the septo-hippocampal system to arousal. Our recent experiments show that there are multiple systems controlling theta activity and that anxiolytics act on several, but not all, of these systems. This pattern of results implies that there are many different types of arousal, only some of which appear to contribute to the generation of anxiety in normal subjects and to the etiology of pathological anxiety.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“McNaughton and Gray (2000) suggest this mechanism within their model of a behavioral inhibition system.”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as McNaughton and Gray (2000)
In the citing paper
“When a discrepancy is noted, the comparator system may halt the current program in an attempt to resolve the mismatch and alter the individual’s actions.”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as McNaughton and Gray, 2000
In the citing paper
“they outline a “comparator of inputs” which compares what is perceived (actual events) to what is desired (expected events).”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as McNaughton and Gray, 2000
In the citing paper
“with decreases in theta power in the vHIP occurring after anxiolytic drug administration (19)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [19]
Citations
Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Gray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477
Self-citationHandbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,756
The Neuropsychology of Anxiety
Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,953
Self-citationHippocampal electrical activity and voluntary movement in the rat
Vanderwolf, C. H. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90092-3 · Cited by 1,928
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536
HIPPOCAMPAL ELECTRICAL ACTIVITY IN AROUSAL
Green, J. D., & Arduini, A. (1954) · Journal of Neurophysiology · doi:10.1152/jn.1954.17.6.533 · Cited by 1,396
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,281
LeDoux, J. E. (1994) · Scientific American · doi:10.1038/scientificamerican0694-50 · Cited by 892
(1997) · Neuroscience · doi:10.1016/s0306-4522(97)00239-x · Cited by 707
Antipredator defensive behaviors in a visible burrow system
Blanchard, R. J., & Blanchard, D. C. (1989) · Journal of comparative psychology · doi:10.1037/0735-7036.103.1.70 · Cited by 663
(1992) · Cited by 626
Cerebral Activity and Behavior: Control by Central Cholinergic and Serotonergic Systems
Vanderwolf, C. H. (1988) · International review of neurobiology · doi:10.1016/s0074-7742(08)60050-1 · Cited by 455
The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety
Davis, M. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90014-w · Cited by 427
LeDoux, J. E. (1992) · Cited by 410
Drug Effects on Fear and Frustration: Possible Limbic Site of Action of Minor Tranquilizers
Gray, J. A. (1977) · Springer eBooks · doi:10.1007/978-1-4684-3180-3_10 · Cited by 376
Self-citationDefense system psychopharmacology: An ethological approach to the pharmacology of fear and anxiety
Blanchard, R. J., Yudko, E. B., Rodgers, R. J., & Blanchard, D. C. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90100-5 · Cited by 367
Electrical activity of the archicortex
Karmos, G. (1986) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(86)90135-5 · Cited by 343
Cortico-Hippocampal Interplay and the Representation of Contexts in the Brain
Miller, R. J. (1991) · Studies of brain function · doi:10.1007/978-3-662-21732-0 · Cited by 339
Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals.
Graeff, F. G. (1994) · PubMed · Cited by 337
McNish, K. A., Gewirtz, J. C., & Davis, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09353.1997 · Cited by 281
DAVIS, M., Walker, D. L., & LEE, Y. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48289.x · Cited by 280
Blanchard, R. J., Griebel, G., Henrie, J. A., & Blanchard, D. C. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00062-0 · Cited by 276
Vertes, R. P. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.46.5.1140 · Cited by 269
Supramammillary cell firing and hippocampal rhythmical slow activity
Kirk, I. J., & McNaughton, N. (1991) · Neuroreport · doi:10.1097/00001756-199111000-00023 · Cited by 245
Self-citationChlordiazepoxide, an anxiolytic benzodiazepine, impairs place navigation in rats
McNaughton, N., & Morris, R. (1987) · Behavioural Brain Research · doi:10.1016/0166-4328(87)90034-9 · Cited by 226
Self-citationKirk, I. J., & McNaughton, N. (1993) · Hippocampus · doi:10.1002/hipo.450030411 · Cited by 212
Self-citationGray, J. A., McNaughton, N., James, D. T. D., & Kelly, P. H. (1975) · Nature · doi:10.1038/258424a0 · Cited by 183
Self-citationThe neuropsychology and neuropharmacology of the dorsal ascending noradrenergic bundle—a review
McNaughton, N., & MASON, S. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90021-0 · Cited by 183
Self-citationThe medial supramammillary nucleus, spatial learning and the frequency of hippocampal theta activity
Pan, W. X., & McNaughton, N. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00431-9 · Cited by 146
Self-citationMcNaughton, N., Logan, B. J., Panickar, K. S., Kirk, I. J., Pan, W. X., Brown, N. T., & Heenan, A. (1995) · Hippocampus · doi:10.1002/hipo.450050605 · Cited by 134
Self-citationCortico-hippocampal interplay and the representation of contexts in the brain
Bruyn, G. W. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90227-x · Cited by 116
On the functional significance of the circuit of papez
Parmeggiani, P. L., Azzaroni, A., & Lenzi, P. (1971) · Brain Research · doi:10.1016/0006-8993(71)90086-2 · Cited by 101
The supramammillary nucleus: Is it necessary for the mediation of hippocampal theta rhythm?
Thinschmidt, J. S., Kinney, G. G., & Kocsis, B. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00045-k · Cited by 96
Cholinergic activation of the electrocorticogram: an amygdaloid activating system
Dringenberg, H. C., & Vanderwolf, C. H. (1996) · Experimental Brain Research · doi:10.1007/bf00228101 · Cited by 94
Wilson, J. R. M., Erwin, V. G., McClea, G. E., Plomin, R. J., Johnson, R. C., Ahem, F. M., & Cole, R. E. (1984) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1984.tb05682.x · Cited by 92
Buspirone produces a dose-related impairment in spatial navigation
McNaughton, N., & Morris, R. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90653-w · Cited by 87
Self-citationBr�cke, F., Petsche, H., Pillat, B., & Deisenhammer, E. (1959) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00362202 · Cited by 45
Dantzer, R. (1991) · Behavioural Processes · doi:10.1016/0376-6357(91)90069-c · Cited by 38
Research works printed but not linked: 2
- McNaughton, 1997, Cholinergic relays in superior colliculus, substantia nigra and amygdala co-operate to gate theta activity, Soc. Neurosci. Abstr., 23, 487
- Vertes, 1997, Brainstem-diencephalo-septohippocampal systems controlling the theta rhythm of the hippocampus, Neuroscience, 81, 893
Cited by
Sorted by citations
A modern learning theory perspective on the etiology of panic disorder.
Bouton, M. E., Mineka, S., & Barlow, D. H. (2001) · Psychological Review · doi:10.1037/0033-295x.108.1.4 · Cited by 1,017
Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300542 · Cited by 769
Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.002 · Cited by 729
Sensory Processing Sensitivity: A Review in the Light of the Evolution of Biological Responsivity
Aron, E. N., Aron, A., & Jagiellowicz, J. (2012) · Personality and Social Psychology Review · doi:10.1177/1088868311434213 · Cited by 645
Selective Attention to Angry Faces in Clinical Social Phobia.
Mogg, K., Philippot, P., & Bradley, B. P. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.1.160 · Cited by 582
Metadata
- Authors
- McNaughton, N., & Gray, J. A.
- Affiliations
- University of Otago (NZ)
- Maudsley Hospital (GB)
- Corresponding author
- McNaughton, Neil
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 61
- Issue
- 3
- Pages
- 161-176
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2056637988
- Cited by
- 553
- References
- 43
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 22 · 2023: 24 · 2022: 33 · 2021: 37 · 2020: 24 · 2019: 17 · 2018: 28 · 2017: 20 · 2016: 25 · 2015: 25 · 2014: 26 · 2013: 34 · 2012: 13
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anxiolytics, behavioral inhibition system, septo-hippocampal system, hippocampal theta activity, arousal, anxiety
- MeSH terms
- Amygdala, Animals, Anxiety Disorders, Arousal, Feedback, Hippocampus, Humans, Neural Inhibition, Neural Pathways, Septum Pellucidum, Theta Rhythm, Anti-Anxiety Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
