Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety

Adhikari, Avishek; Topiwala, Mihir A.; Gordon, Joshua A.

doi:10.1016/j.neuron.2009.12.002

Cited by 729Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety

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Adhikari, Avishek, Topiwala, Mihir A., Gordon, Joshua A.·2010·Neuron

DOI 10.1016/j.neuron.2009.12.002PMC PMC2822726

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Abstract

The ventral hippocampus, unlike its dorsal counterpart, is required for anxiety-like behavior. The means by which it acts are unknown. We hypothesized that the hippocampus synchronizes with downstream targets that influence anxiety, such as the medial prefrontal cortex (mPFC). To test this hypothesis, we recorded mPFC and hippocampal activity in mice exposed to two anxiogenic arenas. Theta-frequency activity in the mPFC and ventral, but not dorsal, hippocampus was highly correlated at baseline, and this correlation increased in both anxiogenic environments. Increases in mPFC theta power predicted avoidance of the aversive compartments of each arena and were larger in serotonin 1A receptor knockout mice, a genetic model of increased anxiety-like behavior. These results suggest a role for theta-frequency synchronization between the ventral hippocampus and the mPFC in anxiety. They are consistent with the notion that such synchronization is a general mechanism by which the hippocampus communicates with downstream structures of behavioral relevance.

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Increases in theta power in the vHIP and mPFC as well as theta synchrony between vHIP and mPFC occur during anxious states.
“and increases in theta power in the vHIP and mPFC as well as theta synchrony between the vHIP and mPFC during anxious states (20).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [20]
MSEW-induced increased vHIP theta power in a novel environment is consistent with reports showing increased theta power and increased coherence between the mPFC and vHIP during heightened states of anxiety.
“Our data showing increased vHIP theta power in the novel environment are consistent with reports showing increased theta power and increased coherence between the mPFC and vHIP during heightened states of anxiety (20).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [20]
Theta activity (4-12 Hz) in the vHPC is associated with anxiety-like behavior in rodents.
“Theta activity (4–12 Hz) in the vHPC is associated with anxiety-like behavior in rodents129.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [129]
Synchronization of PFC activity to the hippocampal theta rhythm has been observed in anxiety assays.
“Synchronization of PFC activity to the hippocampal theta rhythm has been observed in anxiety assays”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [129]
There is a greater degree of theta coherence between infralimbic cortex, CA1 and lateral amygdala in serotonin receptor 1A knockout mice than in wild-type controls.
“there is a greater degree of theta coherence between these regions in serotonin receptor 1A knockout mice, which serve as a genetic mouse model of trait anxiety, than in wild-type controls129.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [129]

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Authors: Adhikari, A., Topiwala, M. A., & Gordon, J. A.
Affiliations: Columbia University (US)
New York State Psychiatric Institute (US)
Corresponding author: Gordon, Joshua A.
ORCID: Adhikari, Avishek
Gordon, Joshua A.
Venue: Neuron
Publisher: Elsevier BV
Published: 2010-01
Volume: 65
Issue: 2
Pages: 257-269
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2009.12.002
PMC: PMC2822726
OpenAlex: W2023595618
Cited by: 729
References: 52
Citations by year: 2026: 31 · 2025: 52 · 2024: 60 · 2023: 52 · 2022: 64 · 2021: 75 · 2020: 40 · 2019: 47 · 2018: 53 · 2017: 42 · 2016: 43 · 2015: 35 · 2014: 28 · 2013: 38 · 2012: 24
FWCI: 20.12
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1293 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K08 MH098623, R01 MH081958)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: ventral hippocampus, medial prefrontal cortex, anxiety, neuronal synchronization, theta oscillations, 5-HT1A receptor, avoidance behavior
MeSH terms: Action Potentials, Animals, Anxiety, Cortical Synchronization, Hippocampus, Male, Theta Rhythm, Prefrontal Cortex, Mice, Knockout, Mice

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Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety

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