Cited by 553Memory and Neural MechanismsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

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Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety

McNaughton, Neil, Gray, Jeffrey A.·2000·Journal of Affective Disorders

DOI 10.1016/s0165-0327(00)00344-x

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Abstract

According to "The Neuropsychology of Anxiety" [Gray, J.A., 1982, The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, Oxford; Gray, J.A., McNaughton, N., 2000, The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, 2nd ed., Oxford University Press, Oxford], anxiolytic drugs of all types act on a behavioural inhibition system, the most important neural component of which is the septo-hippocampal system. Anxiolytics affect septo-hippocampal function by impairing the subcortical control of hippocampal "theta" activity - the principle response of the septo-hippocampal system to arousal. Our recent experiments show that there are multiple systems controlling theta activity and that anxiolytics act on several, but not all, of these systems. This pattern of results implies that there are many different types of arousal, only some of which appear to contribute to the generation of anxiety in normal subjects and to the etiology of pathological anxiety.

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Authors: McNaughton, N., & Gray, J. A.
Affiliations: University of Otago (NZ)
Maudsley Hospital (GB)
Corresponding author: McNaughton, Neil
ORCID: McNaughton, Neil
Gray, Jeffrey A.
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2000-12
Volume: 61
Issue: 3
Pages: 161-176
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/s0165-0327(00)00344-x
OpenAlex: W2056637988
Cited by: 553
References: 43
Citations by year: 2026: 23 · 2025: 32 · 2024: 22 · 2023: 24 · 2022: 33 · 2021: 37 · 2020: 24 · 2019: 17 · 2018: 28 · 2017: 20 · 2016: 25 · 2015: 25 · 2014: 26 · 2013: 34 · 2012: 13
FWCI: 3.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: anxiolytics, behavioral inhibition system, septo-hippocampal system, hippocampal theta activity, arousal, anxiety
MeSH terms: Amygdala, Animals, Anxiety Disorders, Arousal, Feedback, Hippocampus, Humans, Neural Inhibition, Neural Pathways, Septum Pellucidum, Theta Rhythm, Anti-Anxiety Agents

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Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety

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