The Munich Vulnerability Study on Affective Disorders: risk factors for unipolarity versus bipolarity
Abstract
Background An individual with a high genetic load for psychiatric disorders is subject to a considerable risk factor for an affective illness. Family studies usually try to distinguish between bipolar and unipolar disorders since it was suggested that they might show different modes of inheritance. The aim of this study was to differentiate between healthy members of unipolar and bipolar families without a previous history of any psychiatric disorder according to the neurobiological and psychometric findings.Methods We first analysed the results obtained from neurobiological and psychometric measurements taken from 75 healthy subjects who had at least two close relatives with a unipolar and a bipolar disorder. In a second step we examined the subjects with a parental affective disorder; finally, we compared the members of 'pure' unipolar, bipolar and of mixed families to each other.Results The first-degree relatives of unipolar patients showed a significantly higher REM density and scored higher on scales of 'neuroticism' and 'vegetative lability' than the controls. No significant differences could be noticed between the relatives of unipolar and bipolar patients, either when considering the degree of relationship, or the parental type of affective disorder and the 'purity' of the respective families.Conclusions We found some distinct neurobiological and psychometric differences between the relatives of unipolar patients and the control probands. No obvious differences, however, were ascertained between relatives of unipolar and bipolar patients. Therefore, we consider it to be possible that these findings represent potential vulnerability markers for affective disorders in general.
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Non-depressed family members of those with MDD have higher levels of neuroticism than the general population.
“Moreover, neuroticism cosegregates within families (Farmer et al, 2002; Ouimette et al, 1996), and non-depressed family members of those with MDD have higher levels of neuroticism than the general population (Modell et al, 2003).”
From Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study (2016) · cites this paper as Modell et al, 2003
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- Authors
- Modell, S.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Modell, S
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 74
- Issue
- 2
- Pages
- 173-184
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2121254686
- Cited by
- 41
- References
- 54
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- mood disorders, bipolar disorder, major depressive disorder, familial risk, first-degree relatives, REM density, neuroticism, genetic susceptibility, mixed families
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Bipolar Disorder, Depressive Disorder, Female, Humans, Hydrocortisone, Male, Psychometrics, Risk Factors, Severity of Illness Index, Sleep, REM, Polysomnography, Mood Disorders, Genetic Predisposition to Disease, Diagnostic and Statistical Manual of Mental Disorders
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