The Munich vulnerability study on affective disorders: Premorbid polysomnographic profile of affected high-risk probands
Abstract
Background The most characteristic alterations in the sleep electroencephalogram (EEG) during major depression are a shortened latency to rapid eye movement (REM) sleep and an elevated REM density. Because these changes persist in remission, they might represent vulnerability markers. To identify vulnerability markers, we investigated premorbid sleep EEG parameters in healthy high-risk probands (HRPs) with a positive family history of affective disorders.Methods We identified 136 depressed inpatients from referrals to our hospital who had first-degree relatives with an affective disorder as well as first-degree relatives with no current or lifetime history of psychiatric disorders. The latter (the HRP group) were investigated by polysomnography. During the follow-up period, 20 HRPs developed an affective disorder. Their premorbid sleep data were analyzed.Results Premorbid sleep EEG of affected HRPs showed an increased REM density (total night and first REM period) compared with the control group without personal or family history of a psychiatric disorder.Conclusions Increased REM density can be observed not only in patients with depression, but also in their healthy relatives. Moreover, it is predictive for the onset of a psychiatric disorder. Therefore, it can be recommended as a possible endophenotype of these diseases.
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Abundant dreams or nightmares are related to REM sleep abnormalities and psychiatric disorders.
“abundant dreams or nightmares are related to REM sleep abnormalities and psychiatric disorders”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Modell et al., 2005
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works
Sleep and depression--results from psychobiological studies: an overview
Riemann, D., Berger, M., & Voderholzer, U. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00090-4 · Cited by 653 · see citing works
The Changing Rate of Major Depression
Weissman, M. M. (1992) · JAMA · doi:10.1001/jama.1992.03490210080039 · Cited by 408 · see citing works
Holsboer, F., Lauer, C. J., Schreiber, W., & Krieg, J.-C. (2008) · Neuroendocrinology · doi:10.1159/000127023 · Cited by 369 · see citing works
Genetic Determinants of Sleep Regulation in Inbred Mice
Franken, P., Malafosse, A., & Tafti, M. (1999) · SLEEP · doi:10.1093/sleep/22.2.155 · Cited by 284 · see citing works
A functional role for REM sleep in brain maturation
Marks, G. A., Shaffery, J. P., Oksenberg, A., Speciale, S. G., & Roffwarg, H. P. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00018-o · Cited by 283 · see citing works
Datta, S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08607.2000 · Cited by 273 · see citing works
Pairwise multiple comparison procedures: A review.
Jaccard, J. J., Becker, M. A., & Wood, G. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.589 · Cited by 271 · see citing works
From early to late adulthood changes in EEG sleep of depressed patients and healthy volunteers
Lauer, C. J., Riemann, D. W., Wiegand, M. H., & Berger, M. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90355-p · Cited by 247 · see citing works
Age-related changes in sleep in depressed and normal subjects
Gillin, J. C., Duncan, W. C., Murphy, D. L., Post, R. M., Wehr, T. A., Goodwin, F. K., Wyatt, R. J., & Bunney, W. E. (1981) · Psychiatry Research · doi:10.1016/0165-1781(81)90010-x · Cited by 222 · see citing works
Polysomnographic Findings in Recently Drug-Free and Clinically Remitted Depressed Patients
Rush, A. J. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800090068009 · Cited by 201 · see citing works
Generation of rapid eye movements during paradoxical sleep in humans
Peigneux, P., Laureys, S., Fuchs, S., Delbeuck, X., Degueldre, C., Aerts, J., Delfiore, G., Luxen, A., & Maquet, P. (2001) · NeuroImage · doi:10.1006/nimg.2001.0874 · Cited by 162 · see citing works
Steiger, A., von Bardeleben, U., Herth, T., & Holsboer, F. (1989) · Journal of Affective Disorders · doi:10.1016/0165-0327(89)90073-6 · Cited by 160 · see citing works
Thase, M. E., Buysse, D. J., Frank, E., Cherry, C. R., Cornes, C. L., Mallinger, A. G., & Kupfer, D. J. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.502 · Cited by 157 · see citing works
In Quest of Identifying Vulnerability Markers for Psychiatric Disorders by All-Night Polysomnography
Lauer, C. J. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950140063009 · Cited by 147 · see citing works
Reduced rapid eye movement latency *1A predictor of recurrence in depression
Giles, D. E. (1987) · Neuropsychopharmacology · doi:10.1016/0893-133x(87)90007-8 · Cited by 144 · see citing works
Buysse, D. J., Tu, X. M., Cherry, C. R., Begley, A. E., Kowalski, J., Kupfer, D. J., & Frank, E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00198-x · Cited by 131 · see citing works
Rao, U., Dahl, R. E., Ryan, N. D., Birmaher, B. B., Williamson, D. E., Giles, D. E., Rao, R., Kaufman, J., & Nelson, B. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00481-5 · Cited by 123 · see citing works
Electroencephalographic Sleep Profiles Before and After Cognitive Behavior Therapy of Depression
Thase, M. E., Fasiczka, A. L., Berman, S., Simons, A. D., & Reynolds, C. F. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.2.138 · Cited by 117 · see citing works
Controlled Comparison of Electrophysiological Sleep in Families of Probands With Unipolar Depression
Giles, D. E., Kupfer, D. J., Rush, A. J., & Roffwarg, H. P. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.2.192 · Cited by 90 · see citing works
Risk factors in families of unipolar depression. I. Psychiatric illness and reduced REM latency
Giles, D. E., Biggs, M. M., Rush, A. J., & Roffwarg, H. P. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90071-7 · Cited by 82 · see citing works
EEG sleep patterns in man: a twin study
Linkowski, P., Kerkhofs, M., Hauspie, R. C., Susanne, C., & MENDLEWICZ, J. (1989) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(89)90106-5 · Cited by 82 · see citing works
Reynolds, C. F., Hoch, C. C., Buysse, D. J., George, C. J., Houck, P. R., Mazumdar, S., Miller, M. D., Pollock, B. G., Rifai, H., & Frank, E. (1991) · PubMed · Cited by 72 · see citing works
Genetic determinants of EEG sleep: a study in twins living apart
Linkowski, P., Kerkhofs, M., Hauspie, R. C., & MENDLEWICZ, J. (1991) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(91)90048-9 · Cited by 68 · see citing works
EEG sleep in depression and in remission and the REM sleep response to the cholinergic agonist RS 86
Riemann, D. W. (1989) · Neuropsychopharmacology · doi:10.1016/0893-133x(89)90017-1 · Cited by 64 · see citing works
Lauer, C. J., Krieg, J.-C., Riemann, D. W., Zulley, J., & Berger, M. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90074-i · Cited by 61 · see citing works
Ontogeny of REM sleep in ratspossible implications for endogenous depression
VOGEL, G., FENG, P., & Kinney, G. G. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00207-3 · Cited by 58 · see citing works
Koyama, Y., & Sakai, K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00004-x · Cited by 58 · see citing works
Modell, S., Ising, M., Holsboer, F., & Lauer, C. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01398-7 · Cited by 56 · see citing works
Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders
Schreiber, W., Lauer, C. J., Krumrey, K., Holsboer, F., & Krieg, J.-C. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90144-o · Cited by 55 · see citing works
Goetz, R. R., Wolk, S. I., Coplan, J. D., Ryan, N. D., & Weissman, M. M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01092-1 · Cited by 49 · see citing works
First-cycle REM density in never-depressed subjects with borderline personality disorder
Battaglia, M., Ferini‐Strambi, L., Bertella, S., Bajo, S., & Bellodi, L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00213-3 · Cited by 43 · see citing works
Fulton, M., Armitage, R., & Rush, A. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00163-8 · Cited by 43 · see citing works
Modell, S. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00010-1 · Cited by 41 · see citing works
Comparison between eye movement latency and REM sleep parameters in major depression
Wichniak, A., Riemann, D. W., Kiemen, A., Voderholzer, U., & Jernajczyk, W. (2000) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050009 · Cited by 39 · see citing works
Clark, C. P., Dupont, R. M., Golshan, S., Gillin, J. C., Rapaport, M. H., & Kelsoe, J. R. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00135-4 · Cited by 38 · see citing works
Sleep changes during long-term treatment of depression with fluvoxamine - a home-based study
Wilson, S. J., Bell, C., Coupland, N. J., & Nutt, D. (2000) · Psychopharmacology · doi:10.1007/s002139900362 · Cited by 37 · see citing works
Lauer, C. J., Modell, S., Schreiber, W., Krieg, J.-C., & Holsboer, F. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000125744.22031.3a · Cited by 30 · see citing works
Clark, C. P., Gillin, J. C., Golshan, S., DeModena, A., Smith, T. L., Danowski, S., Irwin, M. R., & Schuckit, M. A. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00078-0 · Cited by 24 · see citing works
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Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
The link between depression and diabetes: the search for shared mechanisms
Moulton, C. D., Pickup, J. C., & Ismail, K. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00134-5 · Cited by 670 · see citing works
Brain mechanisms of insomnia: new perspectives on causes and consequences
Someren, E. J. W. V. (2020) · Physiological Reviews · doi:10.1152/physrev.00046.2019 · Cited by 558 · see citing works
Comorbidity of insomnia and depression
Staner, L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.09.003 · Cited by 481 · see citing works
Stress Hormone Regulation: Biological Role and Translation into Therapy
Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473 · see citing works
Self-citationOlbrich, S., & Arns, M. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.816269 · Cited by 371 · see citing works
Sleep and circadian rhythms in mood disorders
Armitage, R. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00968.x · Cited by 344 · see citing works
Wake and sleep EEG provide biomarkers in depression
Steiger, A., & Kimura, M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.013 · Cited by 302 · see citing works
Steiger, A., & Pawlowski, M. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030607 · Cited by 310 · see citing works
A Meta-Analysis of Electroencephalographic Sleep in Depression: Evidence for Genetic Biomarkers
Pillai, V., Kalmbach, D. A., & Ciesla, J. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.016 · Cited by 210 · see citing works
The Functional Role of Dreaming in Emotional Processes
Scarpelli, S., Bartolacci, C., D'Atri, A., Gorgoni, M., & De Gennaro, L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00459 · Cited by 190 · see citing works
“More directly, abundant dreams or nightmares are related to REM sleep abnormalities and psychiatric disorders (Cartwright et al., 2003; Modell et al., 2005; Agargun et al., 2007; Schredl et al., 2009; Sjöström et al., 2009; Marinova et al., 2014; Nakajima et al., 2014).”
BackgroundJobert, M., Wilson, F. J., Ruigt, G. S. F., Brunovský, M., Prichep, L. S., & Drinkenburg, W. H. I. M. (2012) · Neuropsychobiology · doi:10.1159/000343478 · Cited by 186 · see citing works
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics
Dulawa, S. C., & Janowsky, D. S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0219-x · Cited by 187 · see citing works
Heritability of Sleep Electroencephalogram
Ambrosius, U., Lietzenmaier, S., Wehrle, R., Wichniak, A., Kalus, S., Winkelmann, J., Bettecken, T., Holsboer, F., Yassouridis, A., & Frieß, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.002 · Cited by 163 · see citing works
Sleep and Antidepressant Treatment
Wichniak, A., Wierzbicka, A., & Jernajczyk, W. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523608 · Cited by 142 · see citing works
LARA‐CARRASCO, J., NIELSEN, T. A., SOLOMONOVA, E., LEVRIER, K., & POPOVA, A. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00709.x · Cited by 129 · see citing works
Bhagwagar, Z., & Cowen, P. J. (2008) · Psychological Medicine · doi:10.1017/s0033291707001250 · Cited by 124 · see citing works
Sleep as a biomarker for depression
Wichniak, A., Wierzbicka, A., & Jernajczyk, W. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.812067 · Cited by 117 · see citing works
Gottesmann, C., & Gottesman, I. I. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.004 · Cited by 114 · see citing works
Kimura, M., Müller-Preuss, P., Lu, A., Wiesner, E., Flachskamm, C., Wurst, W., Holsboer, F., & Deussing, J. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.46 · Cited by 111 · see citing works
Risk Markers for Depression in Adolescents: Sleep and HPA Measures
Rao, U., Hammen, C. L., & Poland, R. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.27 · Cited by 96 · see citing works
Neuroscience-driven discovery and development of sleep therapeutics
Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.012 · Cited by 63 · see citing works
Slow wave sleep deficits as a trait marker in patients with schizophrenia
Sarkar, S., Katshu, M. Z. U. H., Nizamie, S. H., & Praharaj, S. K. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.08.013 · Cited by 59 · see citing works
Does Effective Management of Sleep Disorders Reduce Depressive Symptoms and the Risk of Depression?
Riemann, D. W. (2009) · Drugs · doi:10.2165/11531130-000000000-00000 · Cited by 61 · see citing works
Duval, F., Lebowitz, B. D., & Macher, J. P. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.2/fduval · Cited by 57 · see citing works
Developmental changes in sleep and their relationships to psychiatric illnesses
Tesler, N., Gerstenberg, M., & Huber, R. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328365a335 · Cited by 57 · see citing works
Kudlow, P. A., Cha, D. S., Lam, R. W. M., & McIntyre, R. S. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.04.017 · Cited by 55 · see citing works
Chronobiology of mood disorders
Malhi, G. S., & Kuiper, S. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12173 · Cited by 53 · see citing works
Sleep disturbances in highly stress reactive mice: Modeling endophenotypes of major depression
Fenzl, T., Touma, C., Romanowski, C. P. N., Ruschel, J., Holsboer, F., Landgraf, R., Kimura, M., & Yassouridis, A. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-29 · Cited by 52 · see citing works
Eidelman, P., Talbot, L. S., Gruber, J., Hairston, I. S., & Harvey, A. G. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00826.x · Cited by 50 · see citing works
Long-term changes in sleep and depressive symptoms of smokers in abstinence
Moreno-Coutiño, A. B., Calderón-Ezquerro, M. D. C., & Drucker-Colı́n, R. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701188901 · Cited by 50 · see citing works
Polysomnography in seasonal affective disorder: A systematic review and meta-analysis
Bertrand, L., d’Ortho, M., Reynaud, È., Lejoyeux, M., Bourgin, P., & Geoffroy, P. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.080 · Cited by 50 · see citing works
Rapid eye movement (REM) sleep: An endophenotype for depression
Modell, S., & Lauer, C. J. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0065-z · Cited by 49 · see citing works
Where Do We Stand in the Quest for Neuropsychiatric Biomarkers and Endophenotypes and What Next?
Ritsner, M. S., & Gottesman, I. I. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9464-4_1 · Cited by 44 · see citing works
Finding behavioral and network indicators of brain vulnerability
Levit-Binnun, N., & Golland, Y. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00010 · Cited by 36 · see citing works
Sleep Pathologies in Depression and the Clinical Utility of Polysomnography
Sculthorpe, L. D., & Douglass, A. B. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005500704 · Cited by 39 · see citing works
The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects
Frieß, E., Modell, S., Brünner, H., Tagaya, H., Lauer, C. J., Holsboer, F., & Ising, M. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0795-2 · Cited by 39 · see citing works
The genetic relationship between neuroticism and autonomic function in female twins
Riese, H., Rosmalen, J. G. M., Ormel, J., van Roon, A. M., Oldehinkel, A. J., & Rijsdijk, F. V. (2006) · Psychological Medicine · doi:10.1017/s0033291706009160 · Cited by 38 · see citing works
Patriquin, M. A., Mellman, T. A., Glaze, D. G., & Alfano, C. A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.02.037 · Cited by 37 · see citing works
Pawlowski, M. A., Gazea, M., Wollweber, B., Dresler, M., Holsboer, F., Keck, M. E., Steiger, A., Adamczyk, M., & Mikoteit, T. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.026 · Cited by 35 · see citing works
Reduced Rapid Eye Movement Density in Parkinson Disease: A Polysomnography-Based Case-Control Study
Schroeder, L. A., Rufra, O., Sauvageot, N., Faÿs, F., Pieri, V., & Diederich, N. J. (2016) · SLEEP · doi:10.5665/sleep.6312 · Cited by 32 · see citing works
Sleep disturbances in pediatric depression
Rao, U. (2011) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2011.09.001 · Cited by 33 · see citing works
Bonapersona, V., Damsteegt, R., Adams, M. L., van Weert, L. T. C. M., Meijer, O. C., Joëls, M., & Sarabdjitsingh, R. A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00181 · Cited by 29 · see citing works
Fulda, S., Romanowski, C. P. N., Becker, A., Wetter, T. C., Kimura, M., & Fenzl, T. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-110 · Cited by 26 · see citing works
Sleep electroencephalography as a biomarker in depression
Steiger, A., Pawlowski, M. A., & Kimura, M. (2015) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s41760 · Cited by 25 · see citing works
Biard, K., Douglass, A. B., & Koninck, J. D. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115598413 · Cited by 25 · see citing works
Frieß, E., Schmid, D. A., Modell, S., Brünner, H., Lauer, C. J., Holsboer, F., & Ising, M. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.005 · Cited by 24 · see citing works
The mechanism, efficacy, and tolerability profile of agomelatine
MacIsaac, S. E., Carvalho, A. F., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.862233 · Cited by 24 · see citing works
Translating depression biomarkers for improved targeted therapies
Bredt, D. S., Furey, M. L., Chen, G., Lovenberg, T., Drevets, W. C., & Manji, H. K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.013 · Cited by 20 · see citing works
REM sleep and depressive symptoms in a population‐based study of middle‐aged and elderly persons
Luik, A. I., Zuurbier, L. A., Whitmore, H. R., Albert Hofman, D., & Tiemeier, H. W. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12273 · Cited by 20 · see citing works
Adamczyk, M., Gazea, M., Wollweber, B., Holsboer, F., Dresler, M., Steiger, A., & Pawlowski, M. A. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.007 · Cited by 20 · see citing works
Leitner, C., Piagge, F. D., Tomic, T., Nozza, F., Fasiello, E., Castronovo, V., Gennaro, L. D., Baglioni, C., Ferini‐Strambi, L., & Galbiati, A. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102048 · Cited by 25 · see citing works
The sleep macroarchitecture of children at risk for depression recruited in sleep centers
Bat‐Pitault, F., Fonséca, D. D., Cortese, S., Strat, Y. L., Kocher, L., Rey, M. F., Adrien, J., Deruelle, C., & Franco, P. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2012.02.007 · Cited by 19 · see citing works
Is REM Density a Measure of Arousal during Sleep?
Barbato, G. (2023) · Brain Sciences · doi:10.3390/brainsci13030378 · Cited by 17 · see citing works
Sleep disturbances and incident risk of major depressive disorder in a population-based cohort
Solelhac, G., Imler, T., Strippoli, M. F., Marchi, N. A., Berger, M., Haba‐Rubio, J., Raffray, T., Bayon, V., Lombardi, A.-S., Ranjbar, S., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115934 · Cited by 17 · see citing works
Surrogate outcomes in neurology, psychiatry, and psychopharmacology
Staner, L. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.3/lstaner · Cited by 17 · see citing works
Sleep in Offspring of Parents With Mood Disorders
Wescott, D. L., Morash-Conway, J., Zwicker, A., Cumby, J., Uher, R., & Rusak, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00225 · Cited by 16 · see citing works
How do the sleep features that characterise depression impact memory?
Harrington, M. O., Reeve, S., Bower, J. L., & Renoult, L. (2023) · Emerging Topics in Life Sciences · doi:10.1042/etls20230100 · Cited by 16 · see citing works
Polysomnographic sleep patterns in depressive, schizophrenic and healthy subjects.
Ilanković, A. N., Damjanović, A., Ilanković, V., Filipović, B., Janković, S. M., & Ilanković, N. (2014) · PubMed · Cited by 14 · see citing works
Effect of Olanzapine on Clinical and Polysomnography Profiles in Patients with Schizophrenia
Katshu, M. Z. U. H., Sarkar, S., & Nizamie, S. H. (2018) · Schizophrenia Research and Treatment · doi:10.1155/2018/3968015 · Cited by 10 · see citing works
Schlafstörungen bei Depression
Zimmermann, C., & Pfeiffer, H. (2006) · Der Nervenarzt · doi:10.1007/s00115-006-2111-1 · Cited by 10 · see citing works
The Schizophrenia Construct After 100 Years of Challenges
Ritsner, M. S., & Gottesman, I. I. (2011) · Springer eBooks · doi:10.1007/978-94-007-0837-2_1 · Cited by 9 · see citing works
Beaupre, L. M., Tiwari, A. K., Gonçalves, V. F., Zai, C. C. H., Marshe, V. S., Lewis, C. M., Martin, N. G., McIntosh, A. M., Adams, M. J., Baune, B. T., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.734077 · Cited by 9 · see citing works
Jiang, J., Li, Z., Li, H., Yang, J., Ma, X., & Yan, B. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.02.020 · Cited by 8 · see citing works
Hein, M., Lanquart, J., Loas, G., Hubain, P., & Linkowski, P. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00297-5 · Cited by 8 · see citing works
Sleep EEG Composition in the First Three Months of Life in Monozygotic and Dizygotic Twins
Vučinović, M., Kardum, G., Bonković, M., Rešić, B., Ursić, A., & Vuković, J. (2013) · Clinical EEG and Neuroscience · doi:10.1177/1550059413497000 · Cited by 8 · see citing works
The Past and Future of Psychiatric Sleep Research
Pollmächer, T. (2023) · Clinical and Translational Neuroscience · doi:10.3390/ctn7040037 · Cited by 8 · see citing works
Ilanković, A. N. (2013) · Macedonian Journal of Medical Sciences · doi:10.3889/mjms.1857-5773.2013.0335 · Cited by 7 · see citing works
RetractedHein, M., Lanquart, J., Mungo, A., Hubain, P., & Loas, G. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112818 · Cited by 7 · see citing works
Methods for REM Sleep Density Analysis: A Scoping Review
Kishi, T. T., Andersen, M. L., Luciano, Y. M., Kakazu, V. A., Tufik, S., & Pires, G. N. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5040051 · Cited by 9 · see citing works
The Wave Model of Sleep Dynamics and an Invariant Relationship between NonREM and REM Sleep
Kharchenko, V. A., & Zhdanova, I. V. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5040046 · Cited by 6 · see citing works
Kheirkhah, M., Duncan, W. C., Yuan, Q., Wang, P. R., Jamalabadi, H., Leistritz, L., Walter, M., Goldman, D. A., Zarate, C. A., & Hejazi, N. S. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02066-7 · Cited by 6 · see citing works
Berger, T., van Calker, D., Brakemeier, E., & Schramm, E. (2019) · Elsevier eBooks · doi:10.1016/b978-3-437-22485-0.00011-7 · Cited by 6 · see citing works
Redefining insomnia: from neural dysregulation to personalized therapeutics
Arias-Carrión, Ó. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2564709 · Cited by 5 · see citing works
Koninck, J. D., Biard, K., Douglass, A. B., & Robillard, R. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s94549 · Cited by 5 · see citing works
Vivid dreams are associated with a high percentage of REM sleep: a prospective study in veterans
Fattal, D., Platti, N., Hester, S., & Wendt, L. H. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10642 · Cited by 4 · see citing works
McGuffin, P. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544125.013 · Cited by 4 · see citing works
Neural circuits and emotional processing in rapid eye movement sleep
Chang, L.-Y., Wang, Y.-Q., Li, Z., Zhang, Y., Huang, Z., & Yang, S.-R. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1674071 · Cited by 3 · see citing works
Berger, T., van Calker, D., Brakemeier, E., & Schramm, E. (2009) · Elsevier eBooks · doi:10.1016/b978-343722481-2.50015-5 · Cited by 3 · see citing works
Genome-Wide Association Study of Sleep Disturbances in Depressive Disorders
Beaupre, L. M., Gonçalves, V. F., Zai, C. C. H., Tiwari, A. K., Harripaul, R., Herbert, D., Freeman, N., Müller, D. J., & Kennedy, J. L. (2019) · Complex Psychiatry · doi:10.1159/000505804 · Cited by 3 · see citing works
Sleep EEG Provides Biomarkers in Depression
Kimura, M., & Steiger, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_12 · Cited by 3 · see citing works
Treatment of Sleep Disorders in Specific Psychiatric Diseases
Wetter, T. C., & Steiger, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_451 · Cited by 2 · see citing works
Berger, T., van Calker, D., Brakemeier, E., & Schramm, E. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-22484-3.00011-6 · Cited by 1 · see citing works
Royant‐Parola, S. (2012) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2012.02.014 · Cited by 1 · see citing works
Berger, T., van Calker, D., Brakemeier, E., & Schramm, E. (2012) · Elsevier eBooks · doi:10.1016/b978-3-437-22483-6.10011-7 · Cited by 1 · see citing works
Ilanković, A. N., Damjanović, A., Ilanković, V., Milovanović, S., Petrovic, D., & Ilanković, N. (2013) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2013.014 · Cited by 1 · see citing works
REM sleep in patients with depression
Steiger, A., & Murck, H. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511921179.040 · Cited by 1 · see citing works
Treatment of Sleep Disorders in Specific Psychiatric Diseases
Wetter, T. C., & Steiger, A. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_451-1 · Cited by 1 · see citing works
Neubauer, D. N. (2022) · Springer eBooks · doi:10.1007/978-981-16-0123-1_17 · Cited by 1 · see citing works
Kamphuis, J., & Meesters, Y. (2020) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2524-5_11 · Cited by 1 · see citing works
Carroll, B. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.032 · Cited by 1 · see citing works
GENETICS OF MAJOR DEPRESSIVE DISORDER IN TREATMENT RESISTANCE AND TRYPTOPHAN DEPLETION
Garriock, H. A. (2006) · UA Campus Repository (The University of Arizona)
Biard, K. (2015) · uO Research (University of Ottawa) · doi:10.20381/ruor-4108
Sleep Abnormalities as a Diagnostic Tool for Major Depressive Disorder
Douglass, A. B., Ward, M., Roerhrs, T., Arfken, C. L., & Boutrous, N. N. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_24
Schlafstörungen bei Depression. Behandlungsmöglichkeiten
Zimmermann, C., & Pfeiffer, H. (2007) · Der Nervenarzt
(2007) · Biological Psychiatry · doi:10.1016/s0006-3223(07)00757-3
(2005) · Biological Psychiatry · doi:10.1016/s0006-3223(05)01358-2
Modell, S., Ising, M., Holsboer, F., & Lauer, C. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.003
Invariant relationship unites REM and NonREM sleepPreprint
Zhdanova, I. V., & Kharchenko, V. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539925
Grundlagen der Diagnostik und Therapie
(2024) · Elsevier eBooks · doi:10.1016/b978-3-437-22487-4.16001-0
- Authors
- Modell, S., Ising, M., Holsboer, F., & Lauer, C. J.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Corresponding author
- Ising, Marcus
- ORCID
- Ising, Marcus
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 58
- Issue
- 9
- Pages
- 694-699
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2031579467
- Cited by
- 103
- References
- 41
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 10 · 2014: 2 · 2013: 10 · 2012: 6
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- mood disorders, major depressive disorder, REM density, REM latency, sleep EEG, family history (medicine), vulnerability indicators, endophenotypes, first-degree relatives
- MeSH terms
- Adolescent, Adult, Electroencephalography, Female, Germany, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep Wake Disorders, Sleep, REM, Polysomnography, Age of Onset, Risk Assessment, Mood Disorders
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