Cited by 941Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

The DOI matches its Crossref record; 153 of the 159 references it cites were found in a registry or an index.

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability

Anderson, Ian M.·2000·Journal of Affective Disorders

DOI 10.1016/s0165-0327(99)00092-0

Open this paper in CoChat — free account

Abstract

Background A meta-analysis of the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs) against tricyclic antidepressants (TCAs) in depressed patients was carried out. Methods Efficacy data from 102 randomised controlled trials (10706 patients) were pooled to provide a summary variance-weighted effect size. Tolerability data from 95 studies (10553 patients) were combined to give variance-weighted relative risk of drop out for all reasons and for adverse effects from each study. The effect of age, treatment setting, severity and TCA dose were examined as well as the performance of individual SSRIs and TCAs where there were sufficient studies. Results There is no overall difference in efficacy between SSRIs and TCAs (effect size -0.03, 95% confidence interval -0.09 to 0.03). TCAs do appear more effective in in-patients (-0.23, -0.40 to -0.05) and amitriptyline is more effective than SSRI comparators (-0.14, -0.25 to -0.03) but publication bias cannot be excluded. The SSRIs are better tolerated, with significantly lower rates of treatment discontinuations overall (relative risk 0.88, 0.83 to 0.93; number needed to treat 26) and due to side effects (0.73, 0.67 to 0.80; number needed to treat 33). Individual SSRIs show a similar advantage except for fluvoxamine which does not differ from the TCAs. Individual TCAs show a similar disadvantage in tolerability compared to SSRIs except for dothiepin against which SSRI treatment results in more side-effect related…

Integrity signals

Registry

Crossref · 10.1016/s0165-0327(99)00092-0

Cites

153 of 153 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,377
Research Diagnostic Criteria
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946
Diagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491
Statistical Methods for Meta-Analysis.
Freeman, P. R., Hedges, L. V., & Olkin, I. (1986) · Biometrics · doi:10.2307/2531069 · Cited by 4,840
Research Diagnostic Criteria
Spitzer, R. L., Endicott, J., & Robins, E. (1978) · PsycTESTS Dataset · doi:10.1037/t04137-000 · Cited by 556
Recognition and management of depression in general practice: consensus statement
Paykel, E. S., & Priest, R. G. (1992) · BMJ · doi:10.1136/bmj.305.6863.1198 · Cited by 540
Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.
Song, F., Freemantle, N., Sheldon, T. A., House, A., Watson, P., Long, A., & Mason, J. (1993) · BMJ · doi:10.1136/bmj.306.6879.683 · Cited by 399
Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study
Danish University Antidepressant Group (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90081-i · Cited by 398

Show all 159 references

Research works printed but not linked: 14

Amin, 1984, Fluvoxamine: antidepressant effects confirmed in a placebo-controlled international study, Clin. Neuropharmacol., 7, S316
Anderson, 1998, A meta-analysis of controlled trials comparing SSRIs in the treatment of depression, J. Psychopharmacol., 12, A20
Dowling, 1990, Fluoxetine: a comparative study with dothiepin, Irish J. Psychiatry, Spring, 3
1993, The treatment of depression in primary care, Effective Health Care Bull., 5, 1
Fawcett, 1989, Fluoxetine versus amitriptyline in adult out-patients with major depression, Curr. Ther. Res., 45, 821
Ginestet, 1989, Fluoxetine in endogenous depression melancholia versus clomipramine, Int. Clin. Psychopharmacol., 4, 37
Harris, 1991, Fluvoxamine versus amitriptyline in depressed hospital out-patients: A multicentre double-blind comparative trial, Br. J. Clin. Res., 2, 89
Hutchinson, 1991, A double blind study in general practice to compare the efficacy and tolerability of paroxetine and amitriptyline in depressed elderly patients, Br. J. Clin. Res., 2, 43
Masco, 1985, Double-blind comparison of fluoxetine and amitriptyline in the treatment of major depressive illness, Adv. Ther., 2, 275
Pakesch, 1991, Depressive syndrome in a clinical trial with private practitioners. [German] OT – Wirkung und Sicherheit von Fluoxetin versus Clomipramin bei ambulanten Patienten mit einem depressiven Syndrom in einer klinischen Prufung bei niedergelassenen Arzten, Wien. Klin. Wochenschr., 103, 176
Pélicier, 1993, Etude multicentrique en double aveugle comparant l’efficacité et la tolerance de la paroxetine et de la clomipramine dans la dépression réactionnelle du sujet âgé, L’Encéphale, XIX, 257
Peters, 1990, Therapy of depression in the psychiatrist’s office – A double-blind multicenter study, Nervenheilkunde, 9, 28
Remick, 1989, A comparison between fluoxetine and doxepin in depressed patients, Curr. Ther. Res., 46, 842
Taneri, 1989, Fluoxetine versus nomifensine in out-patients with neurotic or reactive depression disorder, Int. Clin. Psychopharmacol., 4, 56

Sorted by citations

Items 501–600 of 941

Psychotropic drugs
Wisner, K. L., & Schaefer, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408078-2.00012-3 · Cited by 8
Depression and Anxiety
Curtin, L., Moss, S. E., & Keefe, S. E. (2020) · Springer eBooks · doi:10.1007/978-981-10-5012-1_34-1 · Cited by 5
Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier
Akanuma, S., Han, M., Murayama, Y., Kubo, Y., & Hosoya, K. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03179-0 · Cited by 5
Could use of Selective Serotonin Reuptake Inhibitors During Lactation Cause Persistent Effects on Maternal Bone?
Weaver, S. R., & Hernandez, L. L. (2018) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-018-9390-6 · Cited by 5
Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson, S. T., Ostroff, R. B., Katz, R. B., & Krystal, J. H. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_16 · Cited by 5
Effect of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Carbon Tetrachloride Induced Hepatic Damage in Rats
Abdel-Sala, O. M. E., Sleem, A. A., & Shaffie, N. (2006) · Journal of Pharmacology and Toxicology · doi:10.3923/jpt.2006.395.406 · Cited by 5
Selective serotonin reuptake inhibitors and bone health
Haney, E. M., & Bliziotes, M. M. (2007) · Future Rheumatology · doi:10.2217/17460816.2.2.213 · Cited by 5
Current pharmacological and non pharmacological treatments for obsessivecompulsive disorder
Marazziti, D., Picchetti, M., Baroni, S., Ceresoli, D., Consoli, G., & Dell’Osso, M. C. (2012) · Giornale italiano di psicopatologia/Journal of psychopathology/Italian journal of psychopathology · Cited by 5
Therapeutic tricyclic antidepressant drug monitoring in younger and older depressive patients.
Radziwoń-Zaleska, M., Matsumoto, H., Skalski, M., Wilkowska, J., Januszko, P., Matoszko, D., Dziklińska, A., Gmaj, B., & Szelenberger, W. (2006) · PubMed · Cited by 5
Outcome of a three-phase treatment algorithm for inpatients with melancholic depression
Vermeiden, M., Kamperman, A. M., Hoogendijk, W. J. G., van den Broek, W. W., & Birkenhäger, T. K. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.002 · Cited by 5
Clinical psychopharmacology
Owens, D. G. C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-3137-3.00011-5 · Cited by 5
Antidepressant Selection, Healthcare Resource Consumption and Costs in a Large Workplace Environment
Optenberg, S. A., Lanctôt, K. L., Herrmann, N., & OH, P. I. (2002) · Clinical Drug Investigation · doi:10.2165/00044011-200222100-00005 · Cited by 5
The Serotonergic System and Its Role in Thermoregulation
Negoita, A., Amuzescu, B. P., Mihailescu, D. F., & Bordea, C. (2025) · Physiologia · doi:10.3390/physiologia5040037 · Cited by 4
Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding
Deo, N., Siddiqui, H., Peppercorn, K., Madani, G., Rutherford-Blyth, A., Rutledge, M. T., Williams, M. J. A., McCormick, S. P. A., & Redpath, G. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100889 · Cited by 4
Psychopharmaka
Lohse, M. J., & Müller-Oerlinghausen, B. (2011) · Springer eBooks · doi:10.1007/978-3-642-21992-4_39 · Cited by 4
Pharmacotherapy for the Pseudobulbar Affect in Individuals Who Have Sustained a Traumatic Brain Injury: a Systematic Review
Hicks, A. J., Clay, F. J., Ponsford, J. L., Perry, L. A., Jayaram, M., Batty, R. A., & Hopwood, M. (2020) · Neuropsychology Review · doi:10.1007/s11065-020-09427-7 · Cited by 7
Comparison of Protective Effects of Antidepressants Mediated by Serotonin Receptor in Aβ-Oligomer-Induced Neurotoxicity
Yamamoto, K., Tsuji, M., Oguchi, T., Momma, Y., Ohashi, H., Ito, N., Nohara, T., Nakanishi, T., Ishida, A., Hosonuma, M., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12061158 · Cited by 4
Which antidepressant would psychiatrists and nurses from a developing country choose for themselves?
Chaudhry, I. B., Rahman, R.-U., Minhas, H. M., Chaudhry, N., Taylor, D. M., Ansari, M. A., & Husain, N. (2010) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2010.530668 · Cited by 4
Obsessive compulsive disorder
Stein, D. J. (2013) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v19i3.951 · Cited by 4
Prescription Pattern of Antidepressants in Korea for Major Neurological Disorders: Before the Policy Change in 2017
Park, Y., Baek, E.-S., Choi, J., Lee, J., Lee, S.-H., & Park, K. (2019) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2019.2.6 · Cited by 4
Pharmacological treatments in panic disorder in adults: a network meta-analysis
Guaiana, G., Barbui, C., Meader, N., Davies, S., Furukawa, T. A., Imai, H., Dias, S., Caldwell, D. M., Koesters, M., Tajika, A., et al. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012729.pub2 · Cited by 4
Psychopharmaka
Lohse, M. J. (2020) · Springer eBooks · doi:10.1007/978-3-662-62168-4_38 · Cited by 4
Psychopharmaka
Lohse, M. J., & Müller-Oerlinghausen, B. (2019) · Springer eBooks · doi:10.1007/978-3-662-59046-1_41 · Cited by 4
Prescribing Practice of Antidepressant Drugs at Outpatient Department of a Tertiary Care Teaching Hospital in Bangladesh
Islam, M. R., & Shafique, A. (2017) · Open Journal of Depression · doi:10.4236/ojd.2017.61002 · Cited by 4
Pharmacotherapy for the pseudobulbar affect in individuals who have sustained a traumatic brain injury: a systematic review protocol
Clay, F. J., Hicks, A. J., Perry, L. A., Ponsford, J. L., Jayaram, M., & Hopwood, M. (2018) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2017-003648 · Cited by 4
Psychopharmaka
Lohse, M. J., & Müller-Oerlinghausen, B. (2018) · Springer eBooks · doi:10.1007/978-3-662-57386-0_41 · Cited by 4
Chronic serotonin–norepinephrine reuptake transporter inhibition modifies basal respiratory output in adult mouse in vitro and in vivo
Warren, K., & Solomon, I. C. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.07.004 · Cited by 4
Revised psychopharmacological algorithms for the treatment of mood disorders in Japan
Motohashi, N., Shioe, K., Nakamura, J., Ohshima, A., Yamada, K., Ozawa, H., Someya, T., Uchitomi, Y., & Higuchi, T. (2008) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500701330791 · Cited by 4
Introduction: Psychiatry at a Crossroads
Kirmayer, L. J., Lemelson, R., & Cummings, C. A. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139424745.004 · Cited by 4
Detection, Management Approach of Depression and Antidepressant Utilization in Adult Patients: Results of a Cross-Sectional Survey.
Newale, S., & Bachani, D. S. (2016) · PubMed · Cited by 4
Pharmakotherapie bei therapieresistenter Depression
Tadić, A., & Lieb, K. (2007) · Der Nervenarzt · doi:10.1007/s00115-007-2366-1 · Cited by 5
Does Sertraline Affect Contraction in Endothelium Damaged Aorta
Görmüş, Z. I. S. (2024) · Selçuk Tıp Dergisi · doi:10.30733/std.2023.01688 · Cited by 3
Shooting the messenger: the neurobiology of depression
McCrae, N., & Khan, E. (2014) · British Journal of Neuroscience Nursing · doi:10.12968/bjnn.2014.10.4.185 · Cited by 3
Affektive Störungen
Berger, T., van Calker, D., Brakemeier, E., & Schramm, E. (2009) · Elsevier eBooks · doi:10.1016/b978-343722481-2.50015-5 · Cited by 3
Psychopharmaka
Lohse, M. J., & Müller-Oerlinghausen, B. (2015) · Springer eBooks · doi:10.1007/978-3-662-47186-9_38 · Cited by 3
Medication for Depression: Monoamine Enhancers and Esketamine (Antidepressants)
Park, S., & Shen, W. W. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_133-1 · Cited by 4
Drug utilization research in a primary mental health service in Northeast of Brazil
de Souza, T. T., da Silva, W. B., Quintans, J. D. S. S., Onofre, A. S. C., Onofre, F. B. D. M., & Quintans‐Júnior, L. J. (2012) · Revista Portuguesa de Saúde Pública · doi:10.1016/j.rpsp.2012.03.001 · Cited by 3
The effects of acute treatment with paroxetine, amitriptyline, and placebo on the equilibrium function in healthy subjects: A double-blind crossover trial
Miyata, S., Noda, A., Iwamoto, K., Takahashi, M., Hara, Y., Kojima, J., Iidaka, T., & Ozaki, N. (2013) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2013.813551 · Cited by 3
Antidepressive Pharmakotherapie
Baghai, T. C., Volz, H., & Möller, H. (2009) · Der Internist · doi:10.1007/s00108-009-2320-3 · Cited by 3
Risk of non-Hodgkin lymphoma in relation to tricyclic antidepressant use
Lowry, S., Chubak, J., Press, O. W., McKnight, B., & Weiss, N. S. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2013.04.006 · Cited by 3
Ethical Issues of Placebo-Controlled Studies in Depression and a Randomized Withdrawal Trial in Japan
Tashiro, S., Yamada, M., & Matsui, K. (2012) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318247d24f · Cited by 3
Konsiliar- und Liaisondienste für psychische Störungen
Diefenbacher, A., Burian, R., Klesse, C., & Härter, M. C. (2012) · Elsevier eBooks · doi:10.1016/b978-3-437-22483-6.10029-4 · Cited by 3
The survey of concerns and psychological disorders in elderly sanatorium
Etemadi, A., & Ahmadi, K. (2010) · The Journal of Qazvin University of Medical Sciences · Cited by 3
Depressive Störungen: Major Depression und Persistierende Depressive Störung (Dysthymie)
Beesdo‐Baum, K., & Wïttchen, H. (2020) · Springer eBooks · doi:10.1007/978-3-662-61814-1_46 · Cited by 3
Serotonin Receptors and Antidepressants: Neuroimaging Findings from Preclinical and Clinical Research
Handschuh, P. A., Konadu, M. E., Spurny‐Dworak, B., Silberbauer, L., Murgaš, M., & Lanzenberger, R. R. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_18 · Cited by 2
Selective Serotonin Reuptake Inhibitors
Mozayani, M., & Mozayani, A. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-654-6_5 · Cited by 3
Evidence-based pharmacotherapy of major depressive disorder
Dupuy, J. M., Ostacher, M. J., Huffman, J. C., Perlis, R. H., & Nierenberg, A. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511910395.005 · Cited by 3
Milnacipran treatment of a terminally ill cancer patient with major depressive disorder
Sato, K., Higuchi, H., Yoshida, K., Takahashi, H., Shimizu, T., & Watanabe, J. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.605 · Cited by 3
Fluoxetine versus other types of pharmacotherapy for depression
Cipriani, A., Brambilla, P., Barbui, C., & Hotopf, M. H. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004185 · Cited by 3
Understanding antidepressant change patterns in the UK Biobank
Li, D., Lo, C. W. H., Lewis, C. M., Vassos, E., & Breen, G. D. (2026) · The British Journal of Psychiatry · doi:10.1192/bjp.2026.10719 · Cited by 3
Antidepressants
D, M. F. M., & Papakostas, G. I. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04743-2.50045-7 · Cited by 2
The Need for Non-profit Psychiatric Drug Discovery and Development
Ghaemi, S. N. (2022) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001607 · Cited by 2
Psychopharmaphobia: Elevated fear of antidepressant medication among patients with major depression and breast cancer
Markowitz, J. C., Hellerstein, D. J., Falabella, G. S., Lan, M. J., Levenson, J., Crew, K. D., & Hershman, D. L. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.05.005 · Cited by 2
Effect of age on the response to serotonergic and noradrenergic antidepressants: A systematic review, meta-regression and individual participant data pooled analysis
Ossola, P., Gerra, M. L., Luviè, L., Piacente, A., Marchesi, C., Schoretsanitis, G., & Stewart, J. W. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.02.013 · Cited by 2
Alcohol, Inflammation, and Depression: The Gut-Brain Axis
Cannon, A. R., Hammer, A. M., & Choudhry, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00029-5 · Cited by 2
Glucocorticoid antagonists and depression
Andrews, J. S. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80068-9 · Cited by 2
Psychopharmacological Treatment Options for Global Child and Adolescent Mental Health: The WHO Essential Medicines Lists
Kratochvil, C. J., Kutcher, S., Murphy, A. L., & Gardner, D. M. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181825ae1 · Cited by 2
Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (II) : Antidepressant Efficacy Compared with Placebo, Difference in Efficacy of Antidepressants, and Appropriate Time of Efficacy Judgment in Antidepressant Therapy
Sung, S.-H., Park, S., Han, K., Won, E., Lee, H.-Y., Koo, J.-W., Paik, J., Lee, K., Jeon, H. J., Lee, M., et al. (2013) · 신경정신의학 · doi:10.4306/jknpa.2013.52.5.372 · Cited by 2
Una revisión sobre las intervenciones cognitivo-conductuales en problemas de depresión en la edad avanzada
Izal, M., Márquez, M., Losada, A., Montorio, I., & Nuevo, R. (2003) · Revista Española de Geriatría y Gerontología · doi:10.1016/s0211-139x(03)74852-5 · Cited by 2
Understanding the Antidepressant Debate in the Treatment of Major Depressive Disorder
Naudet, F., Boussageon, R., Palpacuer, C., Gallet, L., Reymann, J., & Falissard, B. (2015) · Therapies · doi:10.2515/therapie/2014228 · Cited by 2
Differential clinical effects of fluvoxamine by the effect of age in Japanese female major depressive patients
Sato, K., & Higuchi, H. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s4918 · Cited by 2
Risk of Non-Hodgkin Lymphoma in Relation to Tricyclic Antidepressant Use
Lowry, S., Chubak, J., McKnight, B., Press, O. W., & Weiss, N. S. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0094 · Cited by 2
Prevalence of trait anxiety in a sample of depressed inpatients and its influence on response to antidepressants
Heijnen, W. T. C. J., van den Broek, W. W., Mulder, P., & Birkenhäger, T. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108099213 · Cited by 2
Revisão das diretrizes da Associação Médica Brasileira para o tratamento da depressão (Versão integral) Revision of the guidelines of the Brazilian Medical Association for the treatment of depression (Complete version)
Fleck, M. P., Berlim, M. T., Lafer, B., Sougey, É. B., Porto, J. A. D., Brasil, M. A. A., Juruena, M. F., & Hetem, L. A. (2009) · Cited by 2
Für jeden Patienten den optimalen Wirkstoff finden
Lieb, M., Rupprecht, R., & Baghai, T. C. (2012) · NeuroTransmitter · doi:10.1007/s15016-012-0565-x · Cited by 2
Recent advances in the biological treatment of mood disorders
McDonald, G., & Hallahan, B. P. (2009) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700000331 · Cited by 2
What Treatments Are Effective for Depression in the Palliative Care Setting?
Irwin, S. A., & Block, S. D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-3796-7.00033-1 · Cited by 2
Fluoxetine-related ecchymosis treated with venlafaxine: a case report
Karaş, H., & Yılmaz, T. (2017) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1367556 · Cited by 2
Review on Antidepressant Medication
Kaulage, S. R., Aldar, K. T., Jadhav, R. P., Jadhav, P. D., & Yadhav, V. D. (2019) · International Journal of Scientific Research in Science and Technology · doi:10.32628/ijsrst1962118 · Cited by 2
Antidepressant‐Like Activity of Agomelatine in the Mouse Unpredictable Chronic Mild Stress Model
Mutlu, O., Gümüşlü, E., Ulak, G., Celikyurt, I. K., Akar, F., Bektaş, E., ŞAHİN, T. D., Kır, H. M., Musul, M. M., & Erden, F. (2013) · Drug Development Research · doi:10.1002/ddr.21064 · Cited by 2
Depressive Störungen: Major Depression und Dysthymie
Beesdo, K., & Wïttchen, H. (2006) · Springer eBooks · doi:10.1007/978-3-540-28511-3_37 · Cited by 2
Antidepressiva
Holsboer‐Trachsler, E., & Holsboer, F. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_53 · Cited by 2
Depression and Anxiety
Curtin, L., Moss, S. E., & Keefe, S. E. (2021) · Springer eBooks · doi:10.1007/978-981-15-6631-8_34 · Cited by 2
Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging
Tsai, C.-J., Chiu, C., Kuo, Y.-Y., Huang, W.-S., Yu, T.-H., Flores, L. G., Yeh, S. H., & Ma, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137035 · Cited by 1
Poststroke Depression—Diagnosis and Treatment—
Osada, M., Muraoka, K., & Meigen, L. I. U. (2007) · リハビリテーション医学 : 日本リハビリテーション医学会誌 · doi:10.2490/jjrmc.44.177 · Cited by 2
Continuing Down the Road to Reintegration: Status and Ongoing Support of the U.S. Air Force's Wounded Warriors
Sims, C. S., Vaughan, C., & Williams, K. (2016) · RAND Corporation eBooks · doi:10.7249/rr1474 · Cited by 2
A comparison of ‘pruning’ during multi-step planning in depressed and healthy individuals
Faulkner, P., Huys, Q. J. M., Renz, D., Eshel, N., Pilling, S., Dayan, P., & Roiser, J. P. (2021) · Psychological Medicine · doi:10.1017/s0033291721000799 · Cited by 2
Risque de chronicisation
Haffen, É. (2005) · L Encéphale · doi:10.1016/s0013-7006(05)82452-2 · Cited by 2
Metaanalysen als Königsweg für die Formulierung von Therapieleitlinien?
Fichter, M. M. (2008) · Verhaltenstherapie · doi:10.1159/000115786 · Cited by 2
Treatment of vasomotor symptoms: Is there an alternative to hormone replacement therapy?
Soliman, N. F. (2005) · Reviews in Gynaecological Practice · doi:10.1016/j.rigp.2005.03.002 · Cited by 2
Acetylcholinesterase Inhibitors May Improve Efficacy and Reduce Adverse Effects of Tricyclic Antidepressants for Depression
Niederhofer, H. (2008) · Drugs & Aging · doi:10.2165/00002512-200825080-00008 · Cited by 2
Factors affecting adherence/compliance among patients diagnosed with unipolar depression in a psychiatric department of a general hospital in Kolkata, India
Banerjee, S. (2011) · Cited by 2
Antidepressiva: Lebensgefährliche Plazebos? - Arznei-Telegramm: fahrlässiges Journal
Fritze, J., Aldenhoff, J. B., Bergmann, F., Maier, W., & Möller, H. (2005) · psychoneuro · doi:10.1055/s-2005-922235 · Cited by 2
Corticosteroidogenesis as a Target of Endocrine Disruption for the Antidepressant Fluoxetine in the Head Kidney of Rainbow Trout (Oncorhynchus mykiss)
Stroud, P. A. (2012) · uO Research (University of Ottawa) · doi:10.20381/ruor-5151 · Cited by 2
Antidepressants
Nelson, J. C. (2015) · Springer eBooks · doi:10.1007/978-3-642-36172-2_361 · Cited by 2
Cariprazine
Stahl, S. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108921275.024 · Cited by 2
G protein-biased LPAR1 agonism promotes prototypic antidepressant effectsPreprint
Kajitani, N., Okada‐Tsuchioka, M., Inoue, A., Miyano, K., Masuda, T., Boku, S., Iwamoto, K., Ohtsuki, S., Uezono, Y., Aoki, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.02.514841 · Cited by 2
Diving with psychotropic medication: review of the literature and clinical considerations
Praktijk Querido, H., Querido, A. L., Dutch Society of Diving and Hyperbaric Medicine, B., Ebbelaar, C. F., Wingelaar, T. T., & Dutch Society of Diving and Hyperbaric Medicine, B. (2023) · Diving and Hyperbaric Medicine Journal · doi:10.28920/dhm53.3.259-267 · Cited by 1
Mental Health Is Heart Health: Adjusting Clinical Guidelines for Depression After Myocardial Infarction
Hardoy, C. R., Shipley, J. H., Kramer, E. N., & McCarron, R. M. (2023) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000385 · Cited by 1
Antidepressant medications: a comprehensive review of efficacy, safety, and future directions
Shah, N., Parmar, J., Shandilya, S., Parmar, D., & Singhal, P. K. (2025) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20253726 · Cited by 2
Management of male premature ejaculation: from past to future
Chang, J., Zhao, W., Ma, L., Zhao, J., Li, Q., Wang, X., Ju, H., Wang, X., & Xing, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1718109 · Cited by 1
Case Report: Severe SIADH and QTc prolongation induced by escitalopram-quetiapine interaction in a CYP2C19 intermediate metabolizer at therapeutic doses
蒋宗辰, Qu, X., Yan, Z., Fang, J., Lan, J., Zhao, X., & Qi, W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1776959 · Cited by 1
The selective serotonin reuptake inhibitor sertraline causes ocular toxicity in larvae of zebrafish (Danio rerio)
Jafari, M., Stehly, Y., & Pampanin, D. M. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1736110 · Cited by 1
Affektive Störungen
Berger, T., van Calker, D., Brakemeier, E., & Schramm, E. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-22484-3.00011-6 · Cited by 1
Serotonin Transporter Gene Polymorphism is Associated with Antidepressant Response to Escitalopram in Multiethnic Malaysians with Major Depressive Disorder: A Preliminary Study
Cp, T., Ac, L., Mohamed, Z., & Nz, Z. (2013) · The Malaysian journal of psychiatry · Cited by 1
El futuro de la farmacoterapia antidepresiva
González-Ferreras, C. (2006) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 1
Balancing bone health and mental health: a new clinical dilemma?
Haney, E. M. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.1.1 · Cited by 2
Trizyklische Antidepressiva zur Initialbehandlung einer depressiven Episode? Pro
Bschor, T. (2015) · Der Nervenarzt · doi:10.1007/s00115-015-0035-3 · Cited by 1
Combined Treatment for Anxiety Disorders
Dowd, S. M., & Clark, L. M. (2013) · Psychopharm Review · doi:10.1097/01.psyphr.0000432862.14260.f1 · Cited by 1
Safety and Tolerability of Antidepressants
Manson, C., Gordon, R., & Baldwin, D. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-24741-0_8 · Cited by 1

Authors: Anderson, I. M.
Affiliations: University of Manchester (GB)
Corresponding author: Anderson, Ian M.
ORCID: Anderson, Ian M.
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2000-04
Volume: 58
Issue: 1
Pages: 19-36
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/s0165-0327(99)00092-0
OpenAlex: W2101963851
Cited by: 940
References: 159
Citations by year: 2026: 9 · 2025: 11 · 2024: 29 · 2023: 22 · 2022: 19 · 2021: 13 · 2020: 175 · 2019: 18 · 2018: 26 · 2017: 34 · 2016: 23 · 2015: 35 · 2014: 44 · 2013: 36 · 2012: 52
FWCI: 4.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: selective serotonin reuptake inhibitors, tricyclic antidepressants, depression, antidepressant efficacy, antidepressant tolerability, treatment discontinuation, adverse drug reactions, amitriptyline, fluvoxamine, dothiepin, inpatient care, publication bias
MeSH terms: Antidepressive Agents, Tricyclic, Depressive Disorder, Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks