Cited by 941Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

The DOI matches its Crossref record; 153 of the 159 references it cites were found in a registry or an index.

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability

Anderson, Ian M.·2000·Journal of Affective Disorders

DOI 10.1016/s0165-0327(99)00092-0

Open this paper in CoChat — free account

Abstract

Background A meta-analysis of the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs) against tricyclic antidepressants (TCAs) in depressed patients was carried out. Methods Efficacy data from 102 randomised controlled trials (10706 patients) were pooled to provide a summary variance-weighted effect size. Tolerability data from 95 studies (10553 patients) were combined to give variance-weighted relative risk of drop out for all reasons and for adverse effects from each study. The effect of age, treatment setting, severity and TCA dose were examined as well as the performance of individual SSRIs and TCAs where there were sufficient studies. Results There is no overall difference in efficacy between SSRIs and TCAs (effect size -0.03, 95% confidence interval -0.09 to 0.03). TCAs do appear more effective in in-patients (-0.23, -0.40 to -0.05) and amitriptyline is more effective than SSRI comparators (-0.14, -0.25 to -0.03) but publication bias cannot be excluded. The SSRIs are better tolerated, with significantly lower rates of treatment discontinuations overall (relative risk 0.88, 0.83 to 0.93; number needed to treat 26) and due to side effects (0.73, 0.67 to 0.80; number needed to treat 33). Individual SSRIs show a similar advantage except for fluvoxamine which does not differ from the TCAs. Individual TCAs show a similar disadvantage in tolerability compared to SSRIs except for dothiepin against which SSRI treatment results in more side-effect related…

Integrity signals

Registry

Crossref · 10.1016/s0165-0327(99)00092-0

Cites

153 of 153 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,377
Research Diagnostic Criteria
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946
Diagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491
Statistical Methods for Meta-Analysis.
Freeman, P. R., Hedges, L. V., & Olkin, I. (1986) · Biometrics · doi:10.2307/2531069 · Cited by 4,840
Research Diagnostic Criteria
Spitzer, R. L., Endicott, J., & Robins, E. (1978) · PsycTESTS Dataset · doi:10.1037/t04137-000 · Cited by 556
Recognition and management of depression in general practice: consensus statement
Paykel, E. S., & Priest, R. G. (1992) · BMJ · doi:10.1136/bmj.305.6863.1198 · Cited by 540
Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.
Song, F., Freemantle, N., Sheldon, T. A., House, A., Watson, P., Long, A., & Mason, J. (1993) · BMJ · doi:10.1136/bmj.306.6879.683 · Cited by 399
Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study
Danish University Antidepressant Group (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90081-i · Cited by 398

Show all 159 references

Research works printed but not linked: 14

Amin, 1984, Fluvoxamine: antidepressant effects confirmed in a placebo-controlled international study, Clin. Neuropharmacol., 7, S316
Anderson, 1998, A meta-analysis of controlled trials comparing SSRIs in the treatment of depression, J. Psychopharmacol., 12, A20
Dowling, 1990, Fluoxetine: a comparative study with dothiepin, Irish J. Psychiatry, Spring, 3
1993, The treatment of depression in primary care, Effective Health Care Bull., 5, 1
Fawcett, 1989, Fluoxetine versus amitriptyline in adult out-patients with major depression, Curr. Ther. Res., 45, 821
Ginestet, 1989, Fluoxetine in endogenous depression melancholia versus clomipramine, Int. Clin. Psychopharmacol., 4, 37
Harris, 1991, Fluvoxamine versus amitriptyline in depressed hospital out-patients: A multicentre double-blind comparative trial, Br. J. Clin. Res., 2, 89
Hutchinson, 1991, A double blind study in general practice to compare the efficacy and tolerability of paroxetine and amitriptyline in depressed elderly patients, Br. J. Clin. Res., 2, 43
Masco, 1985, Double-blind comparison of fluoxetine and amitriptyline in the treatment of major depressive illness, Adv. Ther., 2, 275
Pakesch, 1991, Depressive syndrome in a clinical trial with private practitioners. [German] OT – Wirkung und Sicherheit von Fluoxetin versus Clomipramin bei ambulanten Patienten mit einem depressiven Syndrom in einer klinischen Prufung bei niedergelassenen Arzten, Wien. Klin. Wochenschr., 103, 176
Pélicier, 1993, Etude multicentrique en double aveugle comparant l’efficacité et la tolerance de la paroxetine et de la clomipramine dans la dépression réactionnelle du sujet âgé, L’Encéphale, XIX, 257
Peters, 1990, Therapy of depression in the psychiatrist’s office – A double-blind multicenter study, Nervenheilkunde, 9, 28
Remick, 1989, A comparison between fluoxetine and doxepin in depressed patients, Curr. Ther. Res., 46, 842
Taneri, 1989, Fluoxetine versus nomifensine in out-patients with neurotic or reactive depression disorder, Int. Clin. Psychopharmacol., 4, 56

Sorted by citations

Items 101–200 of 941

Incidence and determinants of long-term use of antidepressants
Meijer, W. E. E., Heerdink, E. R., Leufkens, H. G. M., Herings, R. M. C., Egberts, T. C. G., & Nolen, W. A. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0726-3 · Cited by 112
Evidence for a combined genetic effect of the 5-HT1A receptor and serotonin transporter genes in the clinical outcome of major depressive patients treated with citalopram
Arias, B., Catalán, R., Gastó, C., Gutiérrez, B., & Fañanás, L. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105049037 · Cited by 112
Pain Inhibition Is Deficient in Chronic Widespread Pain but Normal in Major Depressive Disorder
Normand, E., Potvin, S., Gaumond, I., Cloutier, G., Corbin, J.-F., & Marchand, S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04969blu · Cited by 110
Alliances against depression – A community based approach to target depression and to prevent suicidal behaviour
Hegerl, U., Rummel‐Kluge, C., Värnik, A., Arensman, E., & Koburger, N. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.009 · Cited by 117
Predictive value of pharmacological activity for the relative efficacy of antidepressant drugs
Freemantle, N., Anderson, I. M., & Young, P. J. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.4.292 · Cited by 107
Self-citation
Comparing the Effects of Antidepressants: Consensus Guidelines for Evaluating Quantitative Reviews of Antidepressant Efficacy
Lieberman, J. A., Greenhouse, J. B., Hamer, R. M., Krishnan, K. R. R., Nemeroff, C. B., Sheehan, D. V., Thase, M. E., & Keller, M. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300571 · Cited by 105
A Twelve-Week, Double-Blind, Randomized Comparison of Nortriptyline and Paroxetine in Older Depressed Inpatients and Outpatients
Mulsant, B. H., Pollock, B. G., Nebes, R. D., Miller, M. D., Sweet, R. A., Stack, J., Houck, P. R., Bensasi, S., Mazumdar, S., & Reynolds, C. F. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200111000-00009 · Cited by 103
Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance.
Richelson, E. (2003) · PubMed · Cited by 102
Faster, better, stronger: Towards new antidepressant therapeutic strategies
O’Leary, O. F., Dinan, T. G., & Cryan, J. F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.046 · Cited by 104
Increase in Antidepressant Medication in the US Adult Population between 1990 and 2003
Mojtabai, R. (2008) · Psychotherapy and Psychosomatics · doi:10.1159/000112885 · Cited by 100
Effects of Antidepressants in Patients With Functional Esophageal Disorders or Gastroesophageal Reflux Disease: A Systematic Review
Weijenborg, P. W., Schepper, H. U. D., Smout, A. J. P. M., & Bredenoord, A. J. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.06.025 · Cited by 100
A Systematic Approach to Pharmacotherapy for Geriatric Major Depression
Mulsant, B. H., Blumberger, D. M., Ismail, Z., Rabheru, K., & Rapoport, M. J. (2014) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2014.05.002 · Cited by 105
Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence
Sartorius, N., Baghai, T. C., Baldwin, D. S., Barrett, B. M., Brand, U., Fleischhacker, W., Goodwin, G. M., Grunze, H., Knapp, M. R. J., Leonard, B. E., et al. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008255 · Cited by 103
Revisão das diretrizes da Associação Médica Brasileira para o tratamento da depressão (Versão integral)
Fleck, M. P. D. A., Berlim, M. T., Lafer, B., Sougey, É. B., Porto, J. A. D., Brasil, M. A. A., Juruena, M. F., & Hetem, L. A. (2009) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462009000500003 · Cited by 101
A Comparison of the Direct Costs and Cost Effectiveness of Serotonin Reuptake Inhibitors and Associated Adverse Drug Reactions
Sullivan, P. W., Valuck, R. J., Saseen, J. J., & MacFall, H. M. (2004) · CNS Drugs · doi:10.2165/00023210-200418130-00006 · Cited by 98
Emerging drugs for major depressive disorder
Connolly, K. R., & Thase, M. E. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.660146 · Cited by 94
Non-hormonal Systemic Medications and Dry Eye
Wong, J. X. H., Lan, W., Ong, L. M., & Tong, L. H. T. (2011) · The Ocular Surface · doi:10.1016/s1542-0124(11)70034-9 · Cited by 98
Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter
Sinning, S., Musgaard, M., Jensen, M., Severinsen, K., Celik, L., Koldsø, H., Meyer, T., Bols, M., Jensen, H. H., Schiøtt, B., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045401 · Cited by 95
Clinical practice recommendations for depression
Malhi, G. S., Adams, D., Porter, R., Wignall, A., Lampe, L. A., O’Connor, N., Paton, M. B., Newton, L., Walter, G., Taylor, A., et al. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01382.x · Cited by 95
Short psychodynamic supportive psychotherapy, antidepressants, and their combination in the treatment of major depression: a mega-analysis based on three randomized clinical trials
de Maat, S., Dekker, J., Schoevers, R., van Aalst, G., Gijsbers-van Wijk, C., Hendriksen, M., Kool, S., Peen, J., Van, R., & de Jonghe, F. (2008) · Depression and Anxiety · doi:10.1002/da.20305 · Cited by 93
Risk of Cerebrovascular Events Associated with Antidepressant Use in Patients with Depression: A Population-Based, Nested Case-Control Study
Chen, V., Guo, J. J., Li, H., Wulsin, L. R., & Patel, N. C. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1k369 · Cited by 93
Psychotherapy Versus Second-Generation Antidepressants in the Treatment of Depression
Spielmans, G. I., Berman, M. I., & Usitalo, A. N. (2011) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e31820caefb · Cited by 95
Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives
Atmaca, M. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s185757 · Cited by 89
Differences in Medication Adherence and Healthcare Resource Utilization Patterns
Sheehan, D. V., Keene, M. S., Eaddy, M. T., Krulewicz, S., Kraus, J. E., & Carpenter, D. J. (2008) · CNS Drugs · doi:10.2165/00023210-200822110-00005 · Cited by 91
ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy
Mula, M., Brodie, M. J., de Toffol, B., Guekht, A. B., Hečimović, H., Kanemoto, K., Kanner, A. M., Teixeira, A. L., & Wilson, S. J. (2021) · Epilepsia · doi:10.1111/epi.17140 · Cited by 86
Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial
Tran, P., Skolnick, P., Czobor, P., Huang, N. Y., Bradshaw, M., McKinney, A., & Fava, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.003 · Cited by 81
Utilization, price, and spending trends for antidepressants in the US Medicaid program
Chen, Y., Kelton, C. M. L., Jing, Y., Guo, J. J., Li, X., & Patel, N. C. (2008) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2007.06.019 · Cited by 83
A differential response to nortriptyline and fluoxetine in melancholic depression: the importance of age and gender
Joyce, P. R., Mulder, R., Luty, S. E., McKenzie, J. M., & Rae, A. M. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2003.00120.x · Cited by 81
Developing novel treatments for mood disorders: accelerating discovery
Tamminga, C. A., Nemeroff, C. B., Blakely, R., Brady, L. S., Carter, C. S., Davis, K. L., Dingledine, R. J., Gorman, J. M., Grigoriadis, D. E., Henderson, D. C., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01470-1 · Cited by 85
Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in major depressive disorder: A placebo-controlled, randomized study☆
Bortnick, B., El-Khalili, N., Banov, M. D., Adson, D. E., Datto, C. J., Raines, S. R., Earley, W. R., & Eriksson, H. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.031 · Cited by 80
Antidepressant-induced hepatotoxicity
Lucena, M. I., Carvajal, A., Andrade, R. J., & Velasco, A. (2003) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2.3.249 · Cited by 78
Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: A critical review
Pompili, M., Serafini, G., Innamorati, M., Venturini, P., Fusar‐Poli, P., Sher, L., Amore, M., & Girardi, P. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.765593 · Cited by 80
Effect of Selective Serotonin Reuptake Inhibitors on Platelet Activation
Schlienger, R. G., & Meier, C. R. (2003) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200303030-00001 · Cited by 78
Glia in the cytokine-mediated onset of depression: fine tuning the immune response
Jo, W. K., Zhang, Y., Emrich, H. M., & Dietrich, D. E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00268 · Cited by 81
Restoring melancholia in the classification of mood disorders
Taylor, M. A., & Fink, M. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.05.023 · Cited by 77
Pharmacokinetic Pharmacogenetic Prescribing Guidelines for Antidepressants: A Template for Psychiatric Precision Medicine
Nassan, M. M., Nicholson, W. T., Elliott, M. A., Vitek, C. R. R., Black, J. L., & Frye, M. A. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.02.023 · Cited by 79
Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine
Adaikkan, C., Taha, E., Barrera, I., David, O., & Rosenblum, K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.028 · Cited by 79
Association between -1438G/A Promoter Polymorphism in the 5-HT2A Receptor Gene and Fluvoxamine Response in Japanese Patients with Major Depressive Disorder
Sato, K., Yoshida, K., Takahashi, H., Ito, K., Kamata, M., Higuchi, H., Shimizu, T., Itoh, K., Inoue, K., Tezuka, T., et al. (2002) · Neuropsychobiology · doi:10.1159/000066394 · Cited by 77
Antidepressants versus placebo for panic disorder in adults
Bighelli, I., Castellazzi, M., Cipriani, A., Girlanda, F., Guaiana, G., Koesters, M., Turrini, G., Furukawa, T. A., & Barbui, C. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010676.pub2 · Cited by 79
Comparison of escitalopram and citalopram efficacy: A meta-analysis
Auquier, P., Robitail, S., Llorca, P., & Rive, B. (2003) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500310003408 · Cited by 76
Positive Spillovers and Free Riding in Advertising of Prescription Pharmaceuticals: The Case of AntidepressantsPreprint
Shapiro, B. T. (2014) · SSRN Electronic Journal · doi:10.2139/ssrn.2477877 · Cited by 75
The hidden third: improving outcome in treatment-resistant depression
Schlaepfer, T. E., Ågren, H., Monteleone, P., Gastó, C., Pitchot, W., Rouillon, F., Nutt, D., & Kasper, S. F. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111431748 · Cited by 76
Public attitudes toward depression and help-seeking: Impact of the OSPI-Europe depression awareness campaign in four European regions
Kohls, E., Coppens, E., Hug, J., Wittevrongel, E., Audenhove, C. V., Koburger, N., Arensman, E., Székely, A., Gusmão, R. M., & Hegerl, U. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.006 · Cited by 74
A meta-analysis of clinical trials comparing reboxetine, a norepinephrine reuptake inhibitor, with selective serotonin reuptake inhibitors for the treatment of major depressive disorder
Papakostas, G. I., Nelson, J. C., Kasper, S., & Möller, H.-J. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.07.005 · Cited by 73
Antidepressant use in clinical practice: efficacy v. effectiveness
Donoghue, J., & Hylan, T. R. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.42.s9 · Cited by 72
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test
Ghasemi, M., Montaser‐Kouhsari, L., Shafaroodi, H., Nezami, B. G., Ebrahimi, F., & Dehpour, A. R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1609-1 · Cited by 71
The Use of Antidepressants for Headache Prophylaxis
Smitherman, T. A., Walters, A. B., Maizels, M., & Penzien, D. B. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00170.x · Cited by 71
Are All Antidepressants Really the Same? The Case of Fluoxetine
Cipriani, A., Barbui, C., Brambilla, P., Furukawa, T. A., Hotopf, M. H., & Geddes, J. R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0601 · Cited by 71
Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals
Crawford, A., Lewis, S., Nutt, D., Peters, T., Cowen, P., O'Donovan, M., Wiles, N., & Lewis, G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3467-8 · Cited by 64
Medication Use in Children and Adolescents Treated in the Community for Bipolar Disorder
Bhangoo, R. K., Lowe, C. H., Myers, F. S., Treland, J. E., Curran, J., Towbin, K. E., & Leibenluft, E. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603322724904 · Cited by 68
Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review
De Diego-Adeliño, J., Crespo, J. M., Mora, F., Neyra, A., Iborra, P., Gutiérrez-Rojas, L., & Salonia, S. F. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2019705 · Cited by 67
Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex
Felton, T. M., Kang, T. B., Hjorth, S., & Auerbach, S. B. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-002-0688-x · Cited by 66
Effectiveness of antidepressants: comparative remission rates.
Thase, M. E. (2003) · PubMed · Cited by 65
Antidepressant monotherapy: A claims database analysis of treatment changes and treatment duration
Milea, D., Guelfucci, F., Bent‐Ennakhil, N., Toumi, M., & Auray, J. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.11.011 · Cited by 64
Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders
Czéh, B., & Nagy, S. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00056 · Cited by 65
Neurobiology of antidepressant withdrawal: implications for the longitudinal outcome of depression
Harvey, B. H., McEwen, B. S., & Stein, D. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00528-6 · Cited by 63
A critical review of pharmacotherapy for major depressive disorder.
Dupuy, J. M., Ostacher, M. J., Huffman, J., Perlis, R. H., & Nierenberg, A. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000083 · Cited by 61
Antidepressant-like effects of Tagetes lucida Cav. in the forced swimming test
Guadarrama-Cruz, G., Alarcón-Aguilar, F. J., Lezama-Velasco, R., Vázquez-Palacios, G., & Bonilla‐Jaime, H. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.08.013 · Cited by 65
Speed of action: The relative efficacy of short psychodynamic supportive psychotherapy and pharmacotherapy in the first 8 weeks of a treatment algorithm for depression
Dekker, J., Koelen, J. A., Van, H. L., Schoevers, R. A., Peen, J., Hendriksen, M., Kool, S., van Aalst, G., & de Jonghe, F. E. R. E. R. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.10.015 · Cited by 64
Serotonin transporter polymorphisms and the occurrence of adverse events during treatment with selective serotonin reuptake inhibitors
Smits, K. M., Smits, L. J. M., Peeters, F. P. M. L., Schouten, J., Janssen, R. G. J. H., Smeets, H. J. M., van Os, J., & Prins, M. H. (2007) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328014822a · Cited by 62
Is Strength Training as Effective as Aerobic Training for Depression in Older Adults? A Randomized Controlled Trial
Moraes, H., Silveira, H., de Oliveira, N. A., Portugal, E. M. M., de Araújo, N. B., Vasques, P. E., Bergland, A., Santos, T. M., Engedal, K., Coutinho, E. S. F., et al. (2019) · Neuropsychobiology · doi:10.1159/000503750 · Cited by 72
Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease
Pollok, J., van Agteren, J. E., & Carson-Chahhoud, K. V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012346.pub2 · Cited by 59
The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: A double‐blind crossover trial
Iwamoto, K., Takahashi, M., Nakamura, Y., Kawamura, Y., Ishihara, R., Uchiyama, Y., Ebe, K., Noda, A., Noda, Y., Yoshida, K., et al. (2008) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.939 · Cited by 59
Insomnia and Somnolence Associated With Second-Generation Antidepressants During the Treatment of Major Depression
Alberti, S., Chiesa, A., Andrisano, C., & Serretti, A. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000329 · Cited by 60
Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors
Masrour, F. F., Peeri, M., Azarbayjani, M. A., & Hosseini, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2519-6 · Cited by 61
Efficacy and Tolerability of Pharmacotherapies for Borderline Personality Disorder
Bellino, S., Paradiso, E., & Bogetto, F. (2008) · CNS Drugs · doi:10.2165/00023210-200822080-00005 · Cited by 60
Could agomelatine be the ideal antidepressant?
Pandi-Perumal, S. R., Srinivasan, V., Cardinali, D. P., & Monti, M. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.11.1595 · Cited by 60
Americans' Attitudes Toward Psychiatric Medications: 1998–2006
Mojtabai, R. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.8.1015 · Cited by 57
Monoamine Transporters
Lin, Z., Canales, J. J., Björgvinsson, Þ., Thomsen, M., Qu, H., Liu, Q., Torres, G. E., & Caine, S. B. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00001-6 · Cited by 61
Medicating mood with maintenance in mind: bipolar depression pharmacotherapy
Malhi, G. S., Adams, D., & Berk, M. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00711.x · Cited by 54
Factors Affecting Non-Adherence among Patients Diagnosed with Unipolar Depression in a Psychiatric Department of a Tertiary Hospital in Kolkata, India
Banerjee, S., & Varma, R. P. (2013) · Depression Research and Treatment · doi:10.1155/2013/809542 · Cited by 58
A meta-analysis of clinical trials comparing the serotonin (5HT)-2 receptor antagonists trazodone and nefazodone with selective serotonin reuptake inhibitors for the treatment of major depressive disorder
Papakostas, G. I., & D, M. F. M. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.01.1220 · Cited by 57
BDNF Level in the Rat Prefrontal Cortex Increases Following Chronic but Not Acute Treatment with Duloxetine, a Dual Acting Inhibitor of Noradrenaline and Serotonin Re-uptake
Mannari, C., Origlia, N., Scatena, A., Debbio, A. D., Catena, M., Dell’Agnello, G., Barraco, A., Giovannini, L., Dell’Osso, L., Domenici, L., et al. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9254-x · Cited by 60
International study on antidepressant prescription pattern at 20 teaching hospitals and major psychiatric institutions in East Asia: analysis of 1898 cases from China, Japan, Korea, Singapore and Taiwan
UCHIDA, N., CHONG, M., TAN, C. H., NAGAI, H., TANAKA, M., LEE, M., FUJII, S., YANG, S., SI, T., SIM, K., et al. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01702.x · Cited by 56
Effects of Citalopram Treatment of Protracted Withdrawal (Syndrome of Anhedonia) in Patients with Heroin Addiction
Krupitsky, E. M., Burakov, A. M., Didenko, T., Romanova, T. N., Grinenko, N. I., Slavina, T. Y., Grinenko, A. Y., & Tcheremissine, O. V. (2002) · Addictive Disorders & Their Treatment · doi:10.1097/00132576-200205000-00006 · Cited by 56
Coadministration of Modafinil and a Selective Serotonin Reuptake Inhibitor From the Initiation of Treatment of Major Depressive Disorder With Fatigue and Sleepiness
Dunlop, B. W., Crits-Christoph, P. F., Evans, D. L., Hirschowitz, J., Solvason, H. B., Rickels, K., Garlow, S. J., Gallop, R., & Ninan, P. T. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815abefb · Cited by 56
Pharmacotherapy to sustain the fully remitted state
Kennedy, S., McIntyre, R., Fallu, A., & Lam, R. (2002) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0245 · Cited by 56
Isn’t the efficacy of antidepressants clinically relevant? A critical comment on the results of the metaanalysis by Kirsch et al. 2008
Möller, H. J. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0836-5 · Cited by 53
Evidence-based practices in geriatric mental health care: an overview of systematic reviews and meta-analyses.
Bartels, S., Dums, A. R., Oxman, T., Schneider, L., Areán, P., Alexopoulos, G., & Jeste, D. (2003) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(03)00072-8 · Cited by 62
Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
Tardito, D., Milanese, M., Bonifacino, T., Musazzi, L., Grilli, M., Mallei, A., Mocaër, E., Gabriel, C., Racagni, G., Popoli, M., et al. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-68 · Cited by 55
Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment
Burkhouse, K. L., Gorka, S. M., Klumpp, H., Kennedy, A. E., Karich, S. R., Francis, J., Ajilore, O., Craske, M. G., Langenecker, S. A., Shankman, S. A., et al. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11836 · Cited by 55
How do you define remission?
Lecrubier, Y. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.106.s415.2.x · Cited by 56
Prevalence, impact, and management of depression and anxiety in patients with HIV: a review
Chaudhury, S., Bakhla, A., & Saini, R. (2016) · Neurobehavioral HIV Medicine · doi:10.2147/nbhiv.s68956 · Cited by 54
The Management of Individuals with Bipolar Disorder
Malhi, G. S., Adams, D., Cahill, C. M., Dodd, S., & Berk, M. (2009) · Drugs · doi:10.2165/11318850-000000000-00000 · Cited by 54
Drug treatment of depression in the 2000s: an overview of achievements in the last 10 years and future possibilities
Baghai, T. C., Volz, H., & Möller, H. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970601003973 · Cited by 53
Amitriptyline versus other types of pharmacotherapy for depression
Guaiana, G., Barbui, C., & Hotopf, M. H. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004186 · Cited by 54
Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression
Möller, H. ‐., Bitter, I., Bobes, J., Fountoulakis, K. Ν., Höschl, C., & Kasper, S. F. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.08.002 · Cited by 53
Prescriber's Guide
Stahl, S. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108921275 · Cited by 52
Randomized placebo-controlled trial of escitalopram and venlafaxine XR in the treatment of generalized anxiety disorder
Bose, A., Korotzer, A. R., Gommoll, C., & Li, D. (2007) · Depression and Anxiety · doi:10.1002/da.20355 · Cited by 53
Future Antidepressants
Bosker, F. J., Westerink, B. H. C., Cremers, T. I. F. H., Gerrits, M., van der Hart, M. G. C., Kuipers, S. D., van der Pompe, G., Horst, G. J. T., den Boer, J. A., & Korf, J. (2004) · CNS Drugs · doi:10.2165/00023210-200418110-00002 · Cited by 55
Depression in adults: drug and physical treatments.
Barbui, C., Butler, R., Cipriani, A., Geddes, J. R., & Hatcher, S. (2007) · Europe PMC (PubMed Central) · Cited by 52
Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-to-head trials in acute major depression: Systematic review and meta-analysis
Undurraga, J. P., & Baldessarini, R. J. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117711709 · Cited by 51
General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry
Baghai, T. C., Blier, P., Baldwin, D. S., Bauer, M., Goodwin, G. M., Fountoulakis, K. Ν., Kasper, S. F., Leonard, B. E., Malt, U. F., Stein, D. J., et al. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0259-6 · Cited by 51
Once‐daily duloxetine 60 mg in the treatment of major depressive disorder: Multicenter, double‐blind, randomized, paroxetine‐controlled, non‐inferiority trial in China, Korea, Taiwan and Brazil
Lee, P., Shu, L., Xu, X., Wang, C., Lee, M. S., LIU, C., Hong, J. P., Ruschel, S. I., Raskin, J., Colman, S. A., et al. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01666.x · Cited by 50
Risk–benefit analysis of antidepressant drug treatment in the elderly
Álamo, C., Lopez-Munoz, F. J., García‐García, P., & García-Ramos, S. E. (2014) · Psychogeriatrics · doi:10.1111/psyg.12057 · Cited by 50
Outpatient antidepressant drug use in children and adolescents in Germany between 2004 and 2011
Schröder, C., Dörks, M., Kollhorst, B., Blenk, T., Dittmann, R., Garbe, E., & Riedel, O. (2016) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4138 · Cited by 49
Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation
Webhofer, C., Gormanns, P., Tolstikov, V., Zieglgänsberger, W., Sillaber, I., Holsboer, F., & Turck, C. W. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.56 · Cited by 48
Highly Efficient, Enantioselective Syntheses of ( S )-(+)- and ( R )-(−)-Dapoxetine Starting with 3-Phenyl-1-propanol
Kang, S., & Lee, H. (2009) · The Journal of Organic Chemistry · doi:10.1021/jo902176s · Cited by 48
A Critical Overview of the Pharmacologic Management of Treatment-Resistant Depression
Nierenberg, A. A., Katz, J., & D, M. F. M. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2007.01.001 · Cited by 48
Effect of Agomelatine and Fluoxetine on HAM‐D Score, Serum Brain‐Derived Neurotrophic Factor, and Tumor Necrosis Factor‐α Level in Patients With Major Depressive Disorder With Severe Depression
Gupta, K., Gupta, R., Bhatia, M. S., Tripathi, A. K., & Gupta, L. K. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.963 · Cited by 46

Authors: Anderson, I. M.
Affiliations: University of Manchester (GB)
Corresponding author: Anderson, Ian M.
ORCID: Anderson, Ian M.
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2000-04
Volume: 58
Issue: 1
Pages: 19-36
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/s0165-0327(99)00092-0
OpenAlex: W2101963851
Cited by: 940
References: 159
Citations by year: 2026: 9 · 2025: 11 · 2024: 29 · 2023: 22 · 2022: 19 · 2021: 13 · 2020: 175 · 2019: 18 · 2018: 26 · 2017: 34 · 2016: 23 · 2015: 35 · 2014: 44 · 2013: 36 · 2012: 52
FWCI: 4.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: selective serotonin reuptake inhibitors, tricyclic antidepressants, depression, antidepressant efficacy, antidepressant tolerability, treatment discontinuation, adverse drug reactions, amitriptyline, fluvoxamine, dothiepin, inpatient care, publication bias
MeSH terms: Antidepressive Agents, Tricyclic, Depressive Disorder, Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks