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Cited by 71Schizophrenia research and treatmentMotor Control and AdaptationVisual perception and processing mechanisms

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Smooth pursuit eye movements to extra-retinal motion signals: deficits in patients with schizophrenia

Thaker, Gunvant K., Ross, David E., Buchanan, Robert W., Adami, Helene M., Medoff, Deborah R.·1999·Psychiatry Research
DOI 10.1016/s0165-1781(99)00084-0
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Abstract

In order to understand mechanisms underlying the smooth pursuit abnormality(ies) in schizophrenia, new methods, which independently evaluated predictive smooth pursuit responses to extra-retinal motion signals, were developed and tested. The study compared responses to only extra-retinal motion signals in normal volunteers (n = 25), and individuals with a chronic (n = 21) and a recent onset (n = 18) schizophrenia. Subject groups with chronic schizophrenia and recent onset schizophrenia had significantly poorer predictive pursuit than normal subjects in response to only extra-retinal motion signals. The poor predictive pursuit was evident even at low target velocity when the closed-loop pursuit gain was normal in patients with schizophrenia. Ten of the 18 recent onset patients were drug-free at the time of testing and had no or minimum previous exposure to anti-psychotic medications. Re-analyses of the data showed that on most measures of predictive pursuit, drug-free patients were not significantly different from patients who received anti-psychotic drug treatment. Both patient groups had significantly poorer predictive pursuit than normal subjects. These results suggest that a deficit in processing extra-retinal motion may underlie the abnormal smooth pursuit response in schizophrenia. At low target velocities, patients with schizophrenia were able to compensate for the low extra-retinal gain by increasing the gain of response to the retinal slip velocity. This indicates tha…

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  • The reduced-precision simulation reproduces empirical findings in schizophrenia at modest speeds.

    “This reproduces empirical findings in schizophrenia at modest speeds (see Thaker et al., 1999).”

    From The Computational Anatomy of Psychosis (2013) · cites this paper as Thaker et al., 1999

Citations

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Research works printed but not linked: 29

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Metadata

Authors
Thaker, G. K., Ross, D. E., Buchanan, R. W., Adami, H. M., & Medoff, D. R.
Corresponding author
Thaker, Gunvant K.
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1999-11
Volume
88
Issue
3
Pages
209-219
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/s0165-1781(99)00084-0
OpenAlex
W1983097173
Cited by
71
References
1
Citations by year
2026: 1 · 2025: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH40279, MH49826, R01MH049826)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
smooth pursuit eye movements, schizophrenia, antipsychotic drugs, recent-onset schizophrenia, chronic schizophrenia, visual motion processing
MeSH terms
Acute Disease, Adult, Analysis of Variance, Chronic Disease, Female, Humans, Male, Perceptual Masking, Pursuit, Smooth, Schizophrenia, Case-Control Studies

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