The DOI matches its Crossref record; 87 of the 89 references it cites were found in a registry or an index.
Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain
Abstract
The present study was conducted to identify the localization and possible contribution of the two estrogen receptor (ER) subtypes in the rat brain at postnatal (P) days 3, 7 and 14. Evaluation of the distribution of ERalpha and ERbeta immunoreactive (ir) nuclei did not reveal gender differences at the developmental point times examined. With the exception of the cerebral cortex, the pattern of staining for these ERs was unchanged across the postnatal ages examined. The distribution of ERalpha-ir nuclei was wider than ERbeta-ir during brain development. From P3, ERbeta and ERalpha-ir nuclei were found in different regions of the cerebral cortex, basal forebrain, amygdala, thalamus, hypothalamus, mesencephalon, pons, cerebellum and medulla oblongata. In addition, ERalpha-ir nuclei were exclusively detected in the hippocampal subfields, epithalamus and in several circumventricular organs. ERalpha and ERbeta dual immunofluorescence revealed positive nuclei in the medial part of the bed nucleus of the stria terminalis, periventricular preoptic nucleus and in caudal aspects of the ventrolateral part of the ventromedial hypothalamic nucleus. Although the functional significance of the dual expression of both ERs within the same nuclei remains unknown, it is possible that ERs play different roles in gene regulation within the same cell. The presence of ERs in diverse brain regions through early postnatal periods supports a potential role for estrogens in neural differentiation.
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In the citing paper
“In neonatal rodents, ERalpha is expressed relatively abundantly in neocortex while ERbeta is mostly absent (Perez et al., 2003; Zsarnovszky and Belcher, 2001).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Perez et al., 2003
In the citing paper
“Estrogen receptors in frontal cortex are specifically localized to PV+ interneurons: ERbeta, the predominant nuclear estrogen receptor expressed in cortex during puberty and adulthood (Kritzer, 2002; Pérez et al., 2003; Shughrue et al., 1998), is expressed almost exclusively in PV+ interneurons.”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Pérez et al., 2003
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Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
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Metadata
- Authors
- Pérez, S. E., Chen, E.-Y., & Mufson, E. J.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- Mufson, Elliott J
- ORCID
- Mufson, Elliott J
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 145
- Issue
- 1
- Pages
- 117-139
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W1987321973
- Cited by
- 228
- References
- 89
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 5 · 2012: 9
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-16765, AG-14449, P01AG014449, P01AG016765, AG10688)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor alpha, estrogen receptor beta, postnatal brain development, hippocampus, circumventricular organs, bed nucleus of the stria terminalis, ventromedial hypothalamus, cerebral cortex, rat brain
- MeSH terms
- Aging, Animals, Animals, Newborn, Brain, Female, Immunohistochemistry, Male, Neurons, Rats, Inbred F344, Receptors, Estrogen, Estrogen Receptor alpha, Estrogen Receptor beta, Rats
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