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Cited by 106Estrogen and related hormone effectsNeuroscience and Neuropharmacology ResearchNeuroendocrine regulation and behavior

Regional, Laminar, and Cellular Distribution of Immunoreactivity for ER and ERss in the Cerebral Cortex of Hormonally Intact, Adult Male and Female Rats

Kritzer, M. F.·2002·Cerebral Cortex
DOI 10.1093/cercor/12.2.116
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Abstract

Behavioral, biochemical and anatomical studies suggest that estrogen stimulates structure and/or function in the adult cerebral cortex. The studies presented here used immunocytochemistry to map the alpha and beta isoforms of intracellular estrogen receptors (ER alpha, ER beta) in major subdivisions of adult rat cortex to identify potential sites for relevant receptor-mediated hormone actions. These studies revealed that immunoreactivity for ER alpha (ER alpha-IR) and ER beta (ER beta-IR) was present in most cortical areas, was associated exclusively with neurons, and was similar in males and females. Each receptor isoform also had its own unique distribution with respect to cortical regions, layers, and cells. In sensorimotor areas, for example, ER beta-IR was more prominent than ER alpha-IR, and was concentrated in layer V neurons that were immunoreactive for parvalbumin. In contrast, ER alpha-IR was scattered among parvalbumin-immunonegative cells in layers II/III and V/VI. Likewise, in entorhinal cortex, ER beta-IR was present in calbindin-containing cells in layers III-VI, while ER alpha-IR was restricted to small numbers of calbindin-negative neurons in infragranular layers. In sum, ER beta-IR and ER alpha-IR were differentially distributed both with respect to cortical compartments and with respect to each other. Accordingly, estrogen activation at these two sites may be anticipated to impact disparate sets of cortical circuits, cells, and functions.

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Crossref · 10.1093/cercor/12.2.116

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  • Prior to weaning (~P18), ERalpha expression declines precipitously and shortly after ERbeta rises, resulting in higher ERbeta expression in neocortex in adults.

    “Prior to weaning (~P18), ERalpha expression declines precipitously and shortly after ERbeta rises (Prewitt and Wilson, 2007; Wilson et al., 2011; Zsarnovszky and Belcher, 2001), resulting in higher ERbeta expression in neocortex in adults (Kritzer, 2002; Shughrue et al., 1997)”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kritzer, 2002

  • ERbeta in adult neocortex is localized primarily to inhibitory interneurons.

    “which is localized primarily to inhibitory interneurons (Blurton-Jones and Tuszynski, 2002; Kritzer, 2002).”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kritzer, 2002

  • Both males and females show the pattern of estrogen receptor expression in PV+ interneurons.

    “It is important to note that both males and females show this pattern of estrogen receptor expression (Kritzer, 2002)”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kritzer, 2002

  • Estrogen receptors in frontal cortex are specifically localized to PV+ interneurons: ERbeta, the predominant nuclear estrogen receptor expressed in cortex during puberty and adulthood, is expressed almost exclusively in PV+ interneurons.

    “Estrogen receptors in frontal cortex are specifically localized to PV+ interneurons: ERbeta, the predominant nuclear estrogen receptor expressed in cortex during puberty and adulthood (Kritzer, 2002; Pérez et al., 2003; Shughrue et al., 1998), is expressed almost exclusively in PV+ interneurons.”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kritzer, 2002

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Authors
Kritzer, M. F.
Affiliations
State University of New York (US)
Corresponding author
Kritzer, M. F.
ORCID
Kritzer, M. F.
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2002-02-01
Volume
12
Issue
2
Pages
116-128
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/12.2.116
OpenAlex
W2156467824
Cited by
106
References
40
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ns035422-05)
  • National Institute of Neurological Disorders and Stroke (R29NS35422)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
estrogen receptor alpha, estrogen receptor beta, parvalbumin, calbindin, cortical layers, entorhinal cortex, sensorimotor cortex, sex differences
MeSH terms
Animals, Antibody Specificity, Cerebral Cortex, Female, Immunohistochemistry, Male, Motor Cortex, Phenotype, Receptors, Estrogen, Sex Factors, Gonadal Steroid Hormones, Somatosensory Cortex, Tissue Fixation, Rats, Sprague-Dawley, Entorhinal Cortex, Estrogen Receptor alpha, Estrogen Receptor beta, Rats

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