Cited by 228Estrogen and related hormone effectsSexual Differentiation and DisordersHypothalamic control of reproductive hormones

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Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain

Pérez, Sylvia E, Chen, E.-Y, Mufson, Elliott J·2003·Developmental Brain Research

DOI 10.1016/s0165-3806(03)00223-2

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Abstract

The present study was conducted to identify the localization and possible contribution of the two estrogen receptor (ER) subtypes in the rat brain at postnatal (P) days 3, 7 and 14. Evaluation of the distribution of ERalpha and ERbeta immunoreactive (ir) nuclei did not reveal gender differences at the developmental point times examined. With the exception of the cerebral cortex, the pattern of staining for these ERs was unchanged across the postnatal ages examined. The distribution of ERalpha-ir nuclei was wider than ERbeta-ir during brain development. From P3, ERbeta and ERalpha-ir nuclei were found in different regions of the cerebral cortex, basal forebrain, amygdala, thalamus, hypothalamus, mesencephalon, pons, cerebellum and medulla oblongata. In addition, ERalpha-ir nuclei were exclusively detected in the hippocampal subfields, epithalamus and in several circumventricular organs. ERalpha and ERbeta dual immunofluorescence revealed positive nuclei in the medial part of the bed nucleus of the stria terminalis, periventricular preoptic nucleus and in caudal aspects of the ventrolateral part of the ventromedial hypothalamic nucleus. Although the functional significance of the dual expression of both ERs within the same nuclei remains unknown, it is possible that ERs play different roles in gene regulation within the same cell. The presence of ERs in diverse brain regions through early postnatal periods supports a potential role for estrogens in neural differentiation.

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Authors: Pérez, S. E., Chen, E.-Y., & Mufson, E. J.
Affiliations: Rush University Medical Center (US)
Corresponding author: Mufson, Elliott J
ORCID: Mufson, Elliott J
Venue: Developmental Brain Research
Publisher: Elsevier BV
Published: 2003-10
Volume: 145
Issue: 1
Pages: 117-139
ISSN: 0165-3806 (ISSN-L)
DOI: 10.1016/s0165-3806(03)00223-2
OpenAlex: W1987321973
Cited by: 228
References: 89
Citations by year: 2026: 1 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 5 · 2012: 9
FWCI: 6.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Developmental Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-16765, AG-14449, P01AG014449, P01AG016765, AG10688)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: estrogen receptor alpha, estrogen receptor beta, postnatal brain development, hippocampus, circumventricular organs, bed nucleus of the stria terminalis, ventromedial hypothalamus, cerebral cortex, rat brain
MeSH terms: Aging, Animals, Animals, Newborn, Brain, Female, Immunohistochemistry, Male, Neurons, Rats, Inbred F344, Receptors, Estrogen, Estrogen Receptor alpha, Estrogen Receptor beta, Rats

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Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain

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