Tumor necrosis factor receptor fragment attenuates interferon-γ-induced non-REM sleep in rabbits
Abstract
Although the somnogenic actions of interferon-alpha (IFNalpha) and IFNbeta have been reported, the sleep effects of IFNgamma remained unknown. Thus, we investigated the effects of intracerebroventricular injection of human IFNgamma on sleep in rabbits. IFNgamma dose-dependently increased nonrapid eye movement sleep (NREMS), electroencephalographic slow wave activity and brain temperature (Tbr). These effects were markedly attenuated after the heat treatment of IFNgamma. IFNgamma suppressed rapid eye movement sleep if given during the light period, but not if given at dark onset. Although a tumor necrosis factor receptor fragment did not affect any sleep parameters when given at dark onset, it significantly attenuated IFNgamma-induced NREMS and Tbr. These data suggest that IFNgamma may be involved in the sleep responses during infection. Further, IFNgamma may have a synergistic interaction with intrinsic TNFalpha in the brain.
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It was not sleep deprivation per se that was responsible for the improved survival outcome, but rather the enhanced sleep following sleep deprivation.
“This supports the conclusion that it was not sleep deprivation per se that was responsible for the improved survival outcome, but rather the enhanced sleep following sleep deprivation (310).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [310]
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- Authors
- Kubota, T., Majde, J. A., Brown, R. A., & Krueger, J. M.
- Affiliations
- Washington State University (US)
- Office of Naval Research (US)
- ORCID
- Brown, Richard A
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 119
- Issue
- 2
- Pages
- 192-198
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2055501845
- Cited by
- 32
- References
- 47
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 4 · 2013: 2
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS025378)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- interferon-gamma, NREM sleep, sleep regulation, brain temperature, slow-wave activity, REM sleep, circadian timing, TNF-α, neuroimmune interactions
- MeSH terms
- Amino Acid Sequence, Animals, Body Temperature, Fever, Injections, Intraventricular, Interferon-gamma, Male, Molecular Sequence Data, Peptide Fragments, Rabbits, Sleep Stages, Receptors, Tumor Necrosis Factor
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