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Cited by 101Sleep and Wakefulness ResearchStress Responses and CortisolSleep and Work-Related Fatigue

Sleep-deprived mice show altered cytokine production manifest by perturbations in serum IL-1ra, TNFa, and IL-6 levels

Hu, J., Chen, Z., Gorczynski, C.P., Gorczynski, L.Y., Kai, Y., Lee, L., Manuel, J., Gorczynski, R.M.·2003·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2003.03.001
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Abstract

Serum cytokine and chemokine levels were examined in mice following 36 h of sleep deprivation, or after exposure to a known physical stressor (rotational stress). Significant changes in inflammatory cytokines/chemokines (IL-1beta, TNFalpha, IL-1ra, IL-6, and MIP-1beta, MCP-1) were observed following each manipulation, but qualitative and quantitative differences were seen. Interestingly, only physical stress was associated with measured increases in serum corticosterone levels, and with independent evidence (using in vitro immune allostimulation) for a generalized immunosuppression secondary to the experimental manipulation. Our data suggest that altered cytokine production following sleep perturbation occurs by a different mechanism from that (HPA axis) commonly attributed to stress per se.

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Crossref · 10.1016/j.bbi.2003.03.001

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  • PGD2, the most abundant prostanoid in the brain of rodents, is a potent sleep-promoting substance in rats and mice.

    “PGD2, the most abundant prostanoid in the brain of rodents, as a potent, sleep-promoting substance in rats and mice (reviewed in Refs. 246, 551).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [246]

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Authors
Hu, J., Chen, Z., Gorczynski, C. P., Gorczynski, L. Y., Kai, Y., Lee, L., Manuel, J., & Gorczynski, R. M.
Affiliations
University Health Network (CA)
Corresponding author
Gorczynski, R.M.
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2003-12
Volume
17
Issue
6
Pages
498-504
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2003.03.001
OpenAlex
W2011381578
Cited by
101
References
44
Citations by year
2026: 4 · 2025: 2 · 2024: 10 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Space Agency
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
sleep deprivation, cytokine production, inflammatory cytokines, chemokines, interleukin-1 receptor antagonist, TNF-α, interleukin-6, IL-1β, MIP-1β, MCP-1, corticosterone, immunosuppression, hypothalamic-pituitary-adrenal axis, physical stress, rotational stress, mice
MeSH terms
Acebutolol, Analysis of Variance, Animals, Corticosterone, Interleukin-1, Leukocytes, Male, Mice, Inbred C3H, Mice, Inbred C57BL, Sialoglycoproteins, Sleep Deprivation, Stress, Physiological, Tumor Necrosis Factor-alpha, Neuroimmunomodulation, Interleukin-6, Serum, Mice, Interleukin 1 Receptor Antagonist Protein

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