Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment
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Tumor necrosis factor (TNF) is a well characterized sleep-regulatory substance. To study receptor mechanisms for the sleep-promoting effects of TNF, sleep patterns were determined in control and TNF 55 kDa receptor knock-out (TNFR-KO) mice with a B6 × 129 background after intraperitoneal injections of saline or murine TNFα. The TNFR-KO mice had significantly less baseline sleep than the controls. TNFα dose-dependently increased non-rapid eye movement sleep (NREMS) in the controls but did not influence sleep in TNFR-KO mice. Although TNFR-KO mice failed to respond to TNFα, they had an increase in NREMS and a decrease in rapid eye movement sleep after interleukin-1β treatment. These results indicate that TNFα affects sleep via the 55 kDa receptor and provide further evidence that TNFα is involved in physiological sleep regulation. Current results also extend the list of species to mice in which TNFα and interleukin-1β are somnogenic.
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Knockout strains of mice lacking either the type I IL-1 receptor, the 55 kD TNF receptor, or both receptors sleep less than control strains.
“knockout strains of mice that lack either the type I IL-1 receptor (Fang et al, 1998), the 55 kD TNF receptor (Fang et al, 1997), or both of these receptors (Baracchi and Opp, 2008) sleep less than control strains.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Fang et al, 1997
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Self-citationEnhancement of slow-wave sleep by tumor necrosis factor-α is mediated by cyclooxygenase-2 in rats
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Interleukin-4 inhibits spontaneous sleep in rabbits
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Sleep disturbances in HIV infection and their biological basis
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Tumor Necrosis Factor Antagonism Normalizes Rapid Eye Movement Sleep in Alcohol Dependence
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TNFα siRNA Reduces Brain TNF and EEG Delta Wave Activity in Rats
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Self-citationEpidermal growth factor enhances spontaneous sleep in rabbits
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Self-citationVagotomy attenuates tumor necrosis factor-α-induced sleep and EEG δ-activity in rats
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Self-citationIntracerebroventricular injection of TNF-α promotes sleep and is recovered in cervical lymph
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Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination
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Self-citationInterleukin-15 and interleukin-2 enhance non-REM sleep in rabbits
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Self-citationSleep and Psychoneuroimmunology
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Interleukin-13 and transforming growth factor-β1 inhibit spontaneous sleep in rabbits
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Complex neural-immune interactions shape glioma immunotherapy
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Selected Contribution: Circadian rhythm of tumor necrosis factor-α uptake into mouse spinal cord
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MicroRNA 132 alters sleep and varies with time in brain
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Self-citationSepsis-induced alterations in sleep of rats
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Spontaneous, homeostatic, and inflammation-induced sleep in NF-κB p50 knockout mice
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Self-citationCircadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu
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Phosphorylation Hypothesis of Sleep
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Self-citationGenetic Dissection of Sleep Homeostasis
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Tumor necrosis factor receptor fragment attenuates interferon-γ-induced non-REM sleep in rabbits
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Sleep and Psychoneuroimmunology
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Self-citationThe roles of TNF-α and the soluble TNF receptor I on sleep architecture in OSA
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Self-citationActive smoking, sleep quality and cerebrospinal fluid biomarkers of neuroinflammation
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- Authors
- Fang, J., Wang, Y., & Krueger, J. M.
- Affiliations
- University of Memphis (US)
- ORCID
- Wang, Ying
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-08-01
- Volume
- 17
- Issue
- 15
- Pages
- 5949-5955
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W4292956939
- Cited by
- 167
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 10
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health
- Office of Naval Research (N00014)
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TNF-α, TNF receptor knockout mice, sleep regulation, NREM sleep, REM sleep, IL-1β, sleep promotion
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