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Presynaptic nicotinic ACh receptors
Abstract
Nicotinic ACh (nACh) receptors in the CNS are composed of a diverse array of subunits and have a range of pharmacological properties. However, despite the fact that they are ligand-gated cation channels, their physiological functions have not been determined. This has led to increased interest in presynaptic nACh receptors that act to modulate the release of transmitter from presynaptic terminals.
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“Instead, central cholinergic neurotransmission predominantly changes neuronal excitability, alters presynaptic release of neurotransmitters, and coordinates the firing of groups of neurons (Kawai et al., 2007; Rice and Cragg, 2004; Wonnacott, 1997; Zhang and Sulzer, 2004).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Wonnacott, 1997
In the citing paper
“In addition, stimulation of nAChRs can increase the release of glutamate, GABA, dopamine (DA), ACh, norepinephrine, and serotonin (McGehee et al., 1995; Wonnacott, 1997) (Figure 1).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Wonnacott, 1997
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Ca 2+ Signalling in Brain Synaptosomes Activated by Dinucleotides
Miras‐Portugal, M. T., Pintor, J. J., & Gualix, J. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-003-2024-x · Cited by 20
Metadata
- Authors
- Wonnacott, S.
- Affiliations
- University of Bath (GB)
- Corresponding author
- Wonnacott, Susan
- ORCID
- Wonnacott, Susan
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 20
- Issue
- 2
- Pages
- 92-98
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2081391428
- Cited by
- 1,308
- References
- 74
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 15 · 2023: 15 · 2022: 31 · 2021: 16 · 2020: 25 · 2019: 17 · 2018: 25 · 2017: 23 · 2016: 26 · 2015: 36 · 2014: 35 · 2013: 37 · 2012: 22
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- presynaptic nicotinic acetylcholine receptors, ligand-gated cation channels, neurotransmitter release modulation, presynaptic terminals, receptor pharmacology
- MeSH terms
- Animals, Brain, Receptors, Nicotinic, Presynaptic Terminals, Rats
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